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Douxo

Douxo S3 Pyo Shampoo, Contains 3% Chlorhexidine & 0.5% Ophytrium, Antiseptic & Hydrating, For Bacterial or Yeast Skin Infections, For Dogs and Cats, 6.7 fl. oz. (200mL)

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Availability: In Stock.
Fulfilled by Amazon
Arrives Saturday, Mar 28
Order within 19 hours and 51 minutes
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Size: 6.7 oz


Features

  • #1 non-prescription topical brand used and recommended by U.S. veterinarians for dogs and cats with infections/inflammatory dermatological disease
  • Proven to disinfect, hydrate and help support the skin's ecosystem and reduce yeast counts in 7 days
  • Contains ophytrium, a purified natural ingredient that helps support the skins physical barrier for supple hydrated skin and helps soothe irritated skin
  • Free from soaps, sulfates, parabens, dyes and nanoparticles
  • For best results use with the DOUXO PYO Mousse

Description

Soothes, cleans and strengthens the skin barrier. Moisturizes and detangles the fur to leave the coat soft and shiny. DOUXO is the 1 non-prescription topical brand used and recommended by U.S. veterinarians for treatment of dogs and cats with inflammatory dermatological diseases.

Brand: Douxo


Scent: Coconut, Vanilla


Product Benefits: Soothing,Moisturizing,Detangle


Recommended Uses For Product: For Bacterial or Yeast Skin Infections For Dogs and Cats


Material Type Free: Paraben Free,Sulfate Free


Package Dimensions ‏ : ‎ 5.94 x 2.48 x 1.81 inches; 6.7 ounces


Item model number ‏ : ‎ D98410M


Date First Available ‏ : ‎ May 5, 2021


Manufacturer ‏ : ‎ Douxo S3


Best Sellers Rank: #442 in Pet Supplies (See Top 100 in Pet Supplies) #3 in Dog Shampoos


#3 in Dog Shampoos:


Customer Reviews: 4.7 4.7 out of 5 stars (7,070)


Item Form: Liquid


Liquid Volume: 6.7 Fluid Ounces


Special Ingredients: ophytrium


Target Species: dog, cat


Allergen Information: Hypoallergenic


UPC: 850002593426


Manufacturer: Douxo S3


Item Weight: 6.7 ounces


Item model number: D98410M


Date First Available: May 5, 2021


Item Package Dimensions L x W x H: 5.94 x 2.48 x 1.81 inches


Item Weight: 6.7 Ounces


Brand Name: Douxo


Target Audience Keyword: Cats, Dogs, dogs


Directions: Use as recommended by your veterinarian. Wet the fur with cool water from the neck down. Using 1 pump for every 4 lbs, gently massage shampoo onto skin abnormalities to reach the skin. Repeat until entire body is lightly coated with shampoo and leave on for 10 minutes. Rinse thoroughly with cool water. Shampoo amount can be doubled for dogs or cats with long and/or thick fur.


Model Name: PYO


Color: Translucent


Size: 6.7 oz


Age Range Description: All Life Stages


Number of Items: 1


Included Components: Shampoo


Specific Uses for Product: Coat, Skin


Frequently asked questions

If you place your order now, the estimated arrival date for this product is: Saturday, Mar 28

Yes, absolutely! You may return this product for a full refund within 30 days of receiving it.

To initiate a return, please visit our Returns Center.

View our full returns policy here.

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Similar Products

Top Amazon Reviews

    • Great Product, Immediate Relief
Size: 6.7 oz
Easy and reliable to pump shampoo out, lathered very well on thick double coat, less redness and irritation right out of the shower, pleasant smell - nothing to complain about.
Reviewed in the United States on January 28, 2026 by MDog
    • Amazing Stuff - fixed my dog's skin issues!
Size: 6.7 oz
My dog had maybe a yeast infection, skin allergies... idk. He had scabs and dandruff all over his back and belly, and lots of discoloration on his belly which came out of nowhere, He was constantly itching and I felt so bad for him ): I decided to look into it and found people with similar issues. So, with recommendations, I found this shampoo, and also switched his dog food to a better one. With the switch of his dog food, I can't say that one or the other fixed his skin, or both was the solution, but either way, his skin and coat has made a DRASTIC change in just one month. I have been washing him every 3-4 days with this shampoo for a month now, scrubbing him very well and leaving it to sit on him for 5-10 mins. He hates baths but it's what we have to do! This stuff smells great, it suds up and has a nice lather, rinses well, and leaves his coat feeling soft and clean! I can't complain at all. Yes it is pricey as heck, but if it works how can I complain. when I was researching on the internet for my dog's specific issues, I saw people with similar issues say their dog had a yeast infection, and when they took their dog to the vet, this is what their vet recommended! This is what made me take the jump on the purchase and I was not disappointed. ... show more
Reviewed in the United States on November 3, 2025 by Taylor S
    • Worth EVERY Penny
Size: 6.7 oz
This shampoo has been an absolute game-changer for my dog. She’s 13 years old now and has struggled with itching her entire life. We’ve tried just about everything over the years—multiple prescriptions, countless vet-recommended products, and so many over-the-counter solutions. Nothing ever gave her real relief until we started using this shampoo along with the mousse. The difference has been incredible. She used to spend her days constantly scratching and licking, and nights were often the worst—waking up itching, sometimes even crying out in discomfort. It was heartbreaking to watch. Since switching to this product she’s finally comfortable. She sleeps peacefully through the night now, complete with the sweetest little snores, and during the day she’s relaxed instead of restless. It’s been amazing to see her quality of life improve so dramatically. I’ve been using this consistently for months and I’m a repeat purchaser—I’ll never be without it. It not only calms her skin but also keeps her coat soft, clean, and so fresh smelling. I did find that buying directly from the company offers a better price, but regardless, this shampoo (and mousse) are worth every penny. If you have a dog struggling with chronic itching or irritated skin, I can’t recommend this product enough. It has truly been the only thing that has worked for us after years of searching, and it’s given my dog the comfort she deserves. ... show more
Reviewed in the United States on September 19, 2025 by Sharon M
    • Excellent result
Size: 16.9 oz
I liked it very much, the result on my dog's skin, it felt much less itchy, after using it.
Reviewed in the United States on December 3, 2025 by Silvia
    • 5 Stars - HIGHLY Recommend! Works Amazing for Allergies!
Size: 16.9 oz
Hands down the best dog shampoo I've ever used.y American Pitbull is allergic to everything,I even had him undergo the prick test with the Dermatologist & he's allergic to 40 out of 46 items tested for. So his skin is always broken out, even while doing the Allergy Immunotherapy injections, I'm averaging every 3rd day on giving him another bath & this shampoo is helping him so much! He will be completely broken out, red bumps & hives all over his body, I'll give him a bath & within a few hours, or by the next morning (since I usually bathe right before bed) his skin has significantly improved, half the bumps will be gone, most of the hives are completely gone & the redness is nonexistent! The smell is really great as well, it's a lighter scent, I don't smell any chemicals or any of the normal medicated smell at all & it's light enough you can smell it on your pup if you're up close, but otherwise it's not noticeable. The formula is decently thick, it's not runny at all, but it suds up so great as well - another huge thing most medicated shampoos don't do! You also only need a small amount, it actually advises how much to use on the bottle depending on how large your dog is, but it's so easy to suds up, that you don't need much at all. I have a 64lbs Pitbull & I only use 2 pumps on his whole back, 1 on each side & 1 pump on each leg & that's about it. So the cost is a bit expensive, but it lasts forever with how little you need & with how well it works, its 100% worth it. The pump works great, it has the locking mechanism when you turn the pump to the side, so you don't have to worry about it leaking, we transport it every weekend to our MIL's house, and I just throw it in the bag, never leaked before, you don't have to worry about it. I can't recommend this shampoo enough or stress how well its been working for our 4 dogs! ... show more
Reviewed in the United States on September 15, 2025 by Heather
    • It’s great for dogs with skin allergies and irritations
Size: 6.7 oz
My pup has allergies and this shampoo works great! Super easy to use and smells nice her fur is shiny and healthy
Reviewed in the United States on February 7, 2026 by Elijah C
    • Works well!!
Size: 16.9 oz
This is a great shampoo for my maltipoo. It smells nice and decreases his itchiness.
Reviewed in the United States on January 7, 2026 by Birdstomper
    • Small bottle but works
Size: 6.7 oz
I have a shihzu mix and with the weather changing she has been licking and scratching a lot. So she developed fungus on her stomach and paws. I decided to look for shampoo to treat it and since I work with dogs this was a safe smart choice. I did what the instructions said and left it mainly on her stomach and paws for 5-10 minutes. It only has been a few days and her stomach has healed drastically. It’s not 100% better but it says to use 2 times a week. The smell is very light and not overpowering which I like and can be layered. But I would layer it with anything that can’t cause more irritation so a light sensitive condition for allergies would be best after this product. For the price of the bottle is ok, I wish it was a little bigger but for it to be an over the counter medicated shampoo and works, anything for my baby. But it’s not an everyday shampoo, use the bottle as needed and if gets worse then see a vet. Not all products works for every animal, if having doubt confirm with vet but for myself I woulds say the product works ... show more
Reviewed in the United States on January 27, 2026 by Shayna jones

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