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Pet Naturals Calming Chews for Medium and Large Dogs, 30 Chicken Liver Flavored Soft Chews, Anxiety Relief for Barking, Separation Stress, Fireworks and Thunder, Naturally Sourced Behavioral Support

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Availability: In Stock.
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Arrives Tuesday, Mar 24
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Flavor Name: Dog - Medium/Large


Size: 30 Chews


Features

  • MAXIMUM STRENGTH FOR LARGER BREEDS: Specially designed to meet the needs of medium and large dogs. These calming chews provide a potent dose of relaxation-inducing ingredients to help bigger breeds manage stress, anxiety, and over-excitement without the need for multiple small treats.
  • FAST-ACTING 30-MINUTE RELIEF: Dont let anxiety take over. Our formula begins working in as little as 30 minutes, making it the perfect solution for sudden triggers like loud thunderstorms, unexpected fireworks, or high-energy guests arriving at your home.
  • PROVEN NATURAL INGREDIENTS: Formulated with a powerful blend of L-Theanine, Colostrum Calming Complex, and Thiamine (Vitamin B1). These naturally sourced ingredients support the central nervous system to promote a quiet, composed state during moments of high environmental stress.
  • NON-SEDATING & SAFE: Calming for dogs shouldn't mean keeping them sleepy. Our non-pharmaceutical formula promotes relaxation and focus without causing drowsiness, lethargy, or mood changes, allowing your large dog to remain alert and happy while staying calm.
  • TARGETS EXCESSIVE BARKING & STRESS: Ideal for dogs prone to stress-induced barking, pacing, or destructive behavior. Whether its separation anxiety or travel-related nerves, these chews help your pet maintain "quiet moments" at home and on the road.
  • VET FORMULATED & QUALITY ASSURED: Developed by veterinarians and proudly manufactured in the USA in an FDA-registered facility. Every batch is NASC-approved (National Animal Supplement Council), ensuring the highest standards of safety, purity, and ingredient integrity.
  • CLEAN FORMULA FOR SENSITIVE TUMMIES: Pure support with no unnecessary fillers. These chicken liver flavored treats are free from corn, wheat, and artificial ingredients that often cause digestive upset in larger breeds, making them safe for daily or situational use.
  • PICKY EATER APPROVED FLAVOR: Large dogs love the savory chicken liver taste. These soft chews are designed to be enjoyed as a reward, ensuring that even the most finicky dogs will take their supplement without the struggle of pills or messy liquids.

Description

Managing the anxiety of a medium or large dog requires a formula that is as robust as they are. Pet Naturals Calming for Medium and Large Dogs offers a natural, effective way to help your big friend stay grounded during stressful events. From the chaos of holiday fireworks to the quiet dread of a vet visit, our chews provide the behavioral support needed to keep your household peaceful. Our unique formula features the Colostrum Calming Complex and L-Theanine, which mimic the soothing signals found in nature to help manage environmental stress. Unlike heavy sedatives that can leave a large dog feeling disoriented or sluggish, our non-drowsy solution helps them stay calm and focused. This is particularly beneficial for active breeds that need to manage their energy during long car rides or periods of confinement. We understand that large dogs often have sensitive digestive systems, which is why we’ve crafted a clean formula with no corn, wheat, or artificial additives. The result is a highly digestible, delicious chicken liver flavored chew that works in just 30 minutes, giving you a reliable tool for both planned trips and unexpected storms. Backed by 40 years of expertise and veterinarian formulation, Pet Naturals is a name pet parents trust. Help your dog navigate the world with less fear and more confidence. Whether it's reducing separation anxiety or simply fostering a more relaxed environment at home, these chews provide the professional-grade support your large dog deserves.

Brand: Pet Naturals


Flavor: Dog - Medium/Large


Item Form: Chew


Active Ingredients: Thiamine, L-Theanine, Colostrum Calming Complex


Item Weight: 0.23 Pounds


Product Dimensions ‏ : ‎ 2.99 x 2.99 x 3.56 inches; 3.68 ounces


Item model number ‏ : ‎ 0700864.03


Date First Available ‏ : ‎ April 24, 2017


Manufacturer ‏ : ‎ FoodScience, LLC


Best Sellers Rank: #8,259 in Pet Supplies (See Top 100 in Pet Supplies) #65 in Dog Relaxants


#65 in Dog Relaxants:


Customer Reviews: 4.1 4.1 out of 5 stars (2,452)


Flavor: Dog - Medium/Large


Item Form: Chew


Active Ingredients: Thiamine, L-Theanine, Colostrum Calming Complex


Product Benefits: Calming Support


Dog Breed Size: All


Item Weight: 0.23 Pounds


Volume: 5 Liters


Allergen Information: Wheat Free


Brand Name: Pet Naturals


Target Species: Dog


Global Trade Identification Number: 55


Manufacturer: FoodScience, LLC


UPC: 026664011855


Item Type Name: Calming Supplement for Pets


Included Components: Pet Naturals of Vermont - Calming, Behavior Support for Medium & Large Dogs-30 Soft Chews


Unit Count: 3.39 Ounce


Warranty Description: Covered by the FoodScience, LLC 60-Day Satisfaction Guarantee.


Frequently asked questions

If you place your order now, the estimated arrival date for this product is: Tuesday, Mar 24

This item is non-returnable:

Non-returnable due to Food safety reasons

View our full returns policy here.

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Top Amazon Reviews


  • Can not go without it.
Flavor Name: Dog - Medium/Large Size: 30 Chews
My Willow has mod - severe anxiety. She's 60 lbs and I give her three chews in the morning. She is a completely different dog. She's playful and affectionate. It's a chew and doesn't smell bad. I would recommend this to anyone who has a very anxious dog.
Reviewed in the United States on March 8, 2026 by Carmen

  • Effective but not an anxiety cure
Flavor Name: Dog - Medium/Large Size: 30 Chews
For reference, on a previous roadtrip my dog stood for nearly the entire 12 hour drive despite being clearly exhausted (pictured above). Recently we did a 10 hour drive and I gave my dog half a treat at the beginning. After about 30 minutes he actually laid down with the occasional check up on us in the front seat. I could see a significant difference in my dog’s behavior and comfortability. I will say that this isn’t a cure for anxiety in dogs but does help calm their nerves. Along with it calming down my dog, he also was really receptive and enjoyed it as a treat. The smell is a little strong but worth it when considering the benefits. ... show more
Reviewed in the United States on January 7, 2024 by Abby Abby

  • THEY WORK! BUT BE CAREFUL!! READ THIS REVIEW!!!!
Flavor Name: Dog - Medium/Large Size: 30 Chews
I gave these 4 stars because they REALLY WORK, I took a star off because they are deceiving... BEWARE: READ MY STORY: I gave ONE of these to my 55 pound doberman mix who is TOTALLY CRAZY in the afternoon the day they arrived with no expectations because nothing calms her down, ever. Nothing happened. The next day, again in the afternoon, I gave her ONE again. An hour later she was drooling uncontrollably, knocking her head into walls and furniture while walking in the house, walking like she was drunk, her tongue was hanging out of the side of her mouth, she would not eat or drink water and was visibly disoriented and confused and distressed. My husband and I spent the entire rest of the day taking turns sitting with her on a blanket outside trying to put water in her mouth and just watching her breathe and sleep to make sure she was "ok". And yes, we considered taking her to an emergency vet. We didn't do that because we know our dog really well, we've seen her on the verge of death sick, injured, terrified, we know her whole spectrum from great to terrible. And we watched her every second until after midnight when she started to come out of the outrageously intense "drugged" state she was in. The next morning she was back to normal. So... how should I end this review? These things worked on a dog who has been given A LOT of natural remedies for fear, anxiety, aggression, reactivity, etc. and showed absolutely no sign of change from any of them. That means that there is an ingredient or combination of ingredients in these things that is REALLY EFFECTIVE. And she is totally fine, it was apparently just too much for her system. It could be that they become more effective if given daily seeing as there was no effect the first day and the second day with just TWO treats in her system she acted like she was on heroin for about 7 hours. I don't think there is anything bad about these, in fact, to be honest, I'm relieved we actually found something that works on her and no, I didn't throw them out, but no, I haven't given her any since that day. They are sitting in her treat drawer, wrapped up tight in a ziplock bag, way in the back, ha! I will keep them on hand for emergency situations. I have also considered breaking off a TINY piece and giving it to her and then watching her closely as an experiment. Anyway that's my story, sorry it was so long, but I know there are a lot of dog moms (and dads) out there who might not have to go through the scary situation I did if they read this first. I'm not saying don't get these, but I am saying be careful with the dosage!! Also I checked out the company and they seem great. Good luck! ... show more
Reviewed in the United States on July 14, 2017 by Anikka

  • Calming treat dogs
Flavor Name: Dog - Medium/Large Size: 30 Chews
My dog loves these and they help keep him calm
Reviewed in the United States on January 4, 2026 by Ashley shenk

  • N
Flavor Name: Dog - Medium/Large Size: 30 Chews
Good
Reviewed in the United States on November 17, 2025 by Amazon Customer

  • Didn't get it out on time
Flavor Name: Dog - Medium/Large Size: 30 Chews
Didn't get it out on time. Isn't as good as the original one
Reviewed in the United States on March 15, 2026 by Pam Callahan

  • Took time to kick in
Flavor Name: Dog - Medium/Large Size: 30 Chews
I recently adopted a one year old yellow and he has bad separation anxiety. He’s about 100 lbs so I gave him 3 chews around 1pm. Around 4pm, he was still highly anxious so I gave him 2 more since the product says it’s safe to double or triple the dose. Still no change. It wasn’t until about 7pm that he was able to relax. This has been the first time I was able to go to the bathroom alone. I do think these are a good product and I have to keep in mind that he’s only been here for a week so it is going to take some time for him to get used to everything. I can’t really say anything negative or positive about the flavor. He’s very picky when it comes to food and treats. I tried giving him one the day before and he spit it out but today, he took them with no trouble. I now know, with him, I just have to give him these a few hours before. Every dog is different though so while it took some time for them to work on him, you may have a completely different outcome. I still recommend these and I would repurchase them ... show more
Reviewed in the United States on December 17, 2022 by Cala910

  • It helps my senior dog! Very pleased with this product!
Flavor Name: Dog - Medium/Large Size: 30 Chews
My dog is about 14 years old, he has canine cognitive dysfunction syndrome, which causes him to be anxious and unsettled mostly in the evenings and at night. The vet prescribed gabapentin and Prozac to help decrease his anxiety and his struggle to get comfortable and settled in the evenings, but even before we started him on anxiety medicine, these calming chews helped him a little bit, not a ton (but he also has CDS, so he needed some prescription medicine) but they worked enough that I bought these calming chewables for my dog a second time. I feel like they work even better now that he is also taking anxiety medicine. But sometimes he'll wake up in the middle of the night and he won't be able to go back to sleep, but I need to because it's 3 am, so I'll give him half or a quarter of one and it definitely seems to help. Before he started prescription anxiety medicine I gave my 20lb dog one of the chews and it didn't make him sick or sleep all day, but that was before we knew for sure that he had CDS. Every dog is different so I'm not necessarily recommending giving your dog an entire chewable. Start with the instructions on the label to determine how much your dog should be given and after assessing if your dog does well or not, you can always give a little less or a little more. ... show more
Reviewed in the United States on February 25, 2022 by Margaret Anne Rohr

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