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Doctor's BEST

Doctor's Best Vitamin D3 5000 IU Softgels for Men & Women - Vitamin D Supplement for Immune System & Heart Health Support, 125 mcg per Serving, VIT D 3, Non GMO, Gluten Free, Soy Free - 360 Softgels

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Flavor Name: Unflavored


Size: 360 Count (Pack of 1)


Features

  • Vitamin D "Sunshine vitamin" - supports healthy bone density and structure; Vitamin D is required for optimal calcium absorption
  • Product Note: Exposure to heat or sunlight may lead to melting/damage of product. Hence customers are expected to be available during the product delivery
  • Benefits of vitamin D3 - enhances and regulates immune function, supports optimal cardiovascular function and enhances cellular function
  • Get your needed daily dose - Approximately 75% of Americans are deficient in vitamin D. Some researchers suggest that a minimum daily intake of 1,000 IU is necessary to maintain barely adequate blood levels of vitamin D. Others agree that much higher doses are needed to ensure levels are optimal enough to promote health.

Description

Vitamin d from dietary intake or sun exposure requires two activation steps in the body. The first activation occurs in the liver, while the second activation occurs in the kidneys, allowing for regulation of calcium metabolism. However, vitamin d receptors are present throughout the body, in tissue such as the skin, cartilage, heart, prostate, bones and intestines. Thus, the second activation step also takes place in local tissues. Recent discoveries have highlighted the important modulatory effects of vitamin d on various cells of the immune system.vitamin d enhances and regulates immune function. It is known that various cells of the immune system, such as t lymphocytes and antigen presenting cells, express the vitamin d receptor on their surface when activated. Recently, it has been found that treatment of these immune cells with vitamin d influences their expression of cytokines, which are chemical messengers of the immune system. The immune modulating effects of vitamin d extend to monocytes and dendritic cells of the immune system as well. Dendritic cells are important antigen-processing cells of the immune system that function to initiate the immune response. Vitamin d may prevent overactivity of the immune response and keep the immune system in a normal healthy state of vigilance.vitamin d supports optimal cardiovascular function. Research has uncovered the role vitamin d plays in supporting cardiac function. Heart myocytes (cells) express the vitamin d receptor, as do smooth muscle cells of blood vessels. The benefits of vitamin d on the heart are potentially far-reaching. Studies on mice heart cells have shown that vitamin d administration impacts their growth and proliferation. In these cells, vitamin d inhibited the release of a protein that could be detrimental to the function of these cells, displaying cardioprotective properties. It has also been shown that vitamin d has a modulatory effect on heart rhythm.

Is Discontinued By Manufacturer ‏ : ‎ No


Product Dimensions ‏ : ‎ 2.19 x 2.19 x 4.25 inches; 3.84 ounces


Item model number ‏ : ‎ DRB-00250


Date First Available ‏ : ‎ May 18, 2011


Manufacturer ‏ : ‎ Doctor’s Best, Inc


Best Sellers Rank: #5,259 in Health & Household (See Top 100 in Health & Household) #37 in Vitamin D Supplements #658 in Sales & Deals


#37 in Vitamin D Supplements:


#658 in Sales & Deals:


Customer Reviews: 4.8 4.8 out of 5 stars (26,288)


Brand Name: Doctor's BEST


Item Form: Softgel


Primary Supplement Type: Vitamin D3


Diet Type: Gluten Free


Flavor: Unflavored


Product Benefits: Immune Support


Age Range Description: Adult


Specific Uses For Product: Heart, Helps regulate calcium and phosphorus levels needed for healthy bones and teeth*, Supports Immune Health


Special Ingredients: Gluten Free, Non-GMO, Soy-Free


Number of Items: 1


Model Name: Vitamin D3 5, 000 Iu for Healthy Bones, Teeth, Heart & Immune Support, Non-GMO


Container Type: Bottle


Dosage Form: 5000


Global Trade Identification Number: 00


UPC: 632687759690 753950002500


Manufacturer: Doctor’s Best, Inc


Unit Count: 360 Count


Item Weight: 3.84 ounces


Item Dimensions: 2.19 x 2.19 x 4.25 inches


Allergen Information: Gluten Free, Soy Free


Color: White


Frequently asked questions

If you place your order now, the estimated arrival date for this product is: Thursday, Jul 30

This item is non-returnable:

Non-returnable due to Food safety reasons

View our full returns policy here.

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Similar Products

Top Amazon Reviews

    • Reliable, high-quality Vitamin D supplement
Flavor Name: Unflavored Size: 180 Count (Pack of 1)
This is a well-made Vitamin D3 supplement from a brand I trust. The capsules are easy to swallow, and the bottle is clearly labeled with dosage and ingredients, which I appreciate. I like that it is non-GMO and free from gluten and soy. The value is good for the amount provided, and it has been easy to incorporate into my daily routine. Overall, it feels like a solid, straightforward supplement with clean ingredients and good manufacturing standards. ... show more
Reviewed in the United States on December 18, 2025 by Nerk
    • Doctor's Best brand vitamin D3 softgels contain extra virgin olive oil instead of soybean oil
Flavor Name: Unflavored Size: 180 Count (Pack of 1)
Both the 2,000 IU and 5,000 IU versions of Doctor's Best brand vitamin D3 softgels contain extra virgin olive oil instead of soybean oil. Both the 2,000 IU softgels and the 5,000 IU softgels have the exact same dimensions and size. Studies show that people who use extra virgin olive oil at home enjoy a longer life expectancy and a much lower risk of heart attacks, strokes, cancer, infections, pneumonia, influenza, bone fractures, gum disease, and dementia compared to people who use any other vegetable oil at home. Extra virgin olive oil contains substantial quantities of hydroxytyrosol, tyrosol, oleocanthal, squalene, and also very tiny amounts of oleuropein, lignans, coenzyme Q10, and p-coumaric acid. Oleuropein is water-soluble but not fat-soluble so only a very tiny amount of it gets into the olive oil from the olive fruit. IMPORTANT: Remember that the first symptom of hypervitaminosis D is hypercalciuria, which is fine particles of calcium sand coming out in your urine. You would know that the sand feels like microscopic rocks rather than dead skin. If you stop eating/swallowing vitamin D immediately after this happens, there will be no permanent harm and the calcium sand will stop coming out in your urine within 2 days. However, if you continue to eat/swallow your normal dosage of vitamin D after this happens, you will eventually develop irreversible damage to your arteries, kidneys, lungs, heart, and possibly other organs. Although the vast majority of people would need to eat/swallow at least 40,000 IU of vitamin D3 per day to experience hypercalciuria, I briefly developed hypercalciuria with a daily dose of only 15,000 IU per day: 4,000 IU from vitamin D3 softgels and 9,000 IU to 13,000 IU daily from eating shiitake mushrooms(D2) and pink salmon with the skin(D3). Both foods are extremely good sources of vitamin D. Until recently, I had been swallowing only 2,000 IU of vitamin D3 daily for several years and had never experienced any problems whatsoever. However, my scariest moment happened about one week after I discontinued my daily 4,000 IU of vitamin D3 softgels. The calcium sand in my urine, which for me is always colored orange, returned for just one more day because I ate lots of shiitake mushrooms on that day. I have never had kidney stones in my whole life and, as far as I can tell, I still haven't developed any kidney stones. UPDATE: I can swallow 5,125 IU of vitamin D3 daily (5,000 IU from 1 softgel and 125 IU from a 600mg calcium carbonate tablet) plus eat lots of various fish(D3) [for 21 days] and still not develop calcium sand in my urine. UPDATE: I can swallow 10,125 IU of vitamin D3 daily plus eat lots of various fish(D3) [for 21 days] and still not develop calcium sand in my urine. UPDATE: I can swallow 15,125 IU of vitamin D3 daily plus eat lots of various fish(D3) [for 21 days] and still not develop calcium sand in my urine. UPDATE: I can swallow 20,125 IU of vitamin D3 daily plus eat lots of various fish(D3) [for 7 days] and still not develop calcium sand in my urine. UPDATE: I can swallow 25,125 IU of vitamin D3 daily plus eat lots of various fish(D3) [for 3 days] and still not develop calcium sand in my urine. UPDATE: I can swallow 50,125 IU of vitamin D3 daily plus eat lots of various fish(D3) [for 1 day] and still not develop calcium sand in my urine. The only way I can trigger the orange-colored calcium sand to form in my urine is to eat lots of dried shiitake mushrooms(D2) from China. The orange-colored calcium sand will always appear in my urine about 3 to 5 hours after I eat about a half pound (dry weight) of shiitake mushrooms on any day, even if I had stopped eating fish(D3) and stopped swallowing vitamin D3 softgels for many weeks. This proves to me that the mushroom farmers in China and the U.S. love to expose their mushrooms to plenty of natural sunlight and/or expose their mushrooms to ultraviolet fluorescent lighting just before shipping them to market. This increases the vitamin D2 in mushrooms by 100 times or more, thereby saving many human lives by preventing cancer, heart disease, and hip fractures but endangering mushroom lovers with hypervitaminosis D. BREAKING NEWS: I'm not continuing this experiment any further. I will be swallowing only 125 IU of vitamin D3 for three months, then resume at a dosage of only 5,000 IU per week plus 125 IU per day the rest of my life. Why so low? The reason is that according to a 2010 scientific study by Karl Michaëlsson and others, swallowing 5,000 IU per day of vitamin D3 will approximately double the risk of death from cancer in most people compared to people who swallow only 1,000 IU or 2,000 IU per day. Swallowing 10,000 IU per day of vitamin D3 will approximately triple the risk of death from cancer in most people compared to people who swallow only 1,000 IU or 2,000 IU per day. Swallowing 15,000 IU per day of vitamin D3 will approximately quadruple the risk of death from cancer in most people compared to people who swallow only 1,000 IU or 2,000 IU per day. However, swallowing only 1,000 IU or 2,000 IU per day of vitamin D3 will lower the risk of death from cancer in most people by approximately 50% compared to people who don't swallow any vitamin D2 or D3. My final advice: Swallow 2,000 IU of vitamin D3 per day if you don't eat much fish or mushrooms. Swallow only 1,000 IU of vitamin D3 per day if you eat plenty of fish and/or plenty of mushrooms and/or damage your skin and eyes with plenty of sunshine. It's perfectly OK to swallow vitamin D2 instead of vitamin D3 if you prefer. Both are equally well absorbed. If you are willing to regularly measure your blood hydroxyvitamin D levels, then aim for the optimal range of "serum 25(OH)D," which is exactly 24 to 34 ng/mL. That's the exact same thing as 60 to 85 nmol/L. The higher or lower (farther) you go above or below (away from) that optimal range, the higher your risk of cancer death, cardiovascular death, bone fractures, and impaired immune function. In my opinion, mushroom farmers should completely stop irradiating their mushrooms with ultraviolet light. They could be causing just as many cancer deaths, heart attack deaths, and hip fracture deaths among mushroom lovers as they are preventing among occasional mushroom eaters. Also, the U.S. government should measure the amount of vitamin D in mushroom products. MEDICAL INFO: Orange-colored calcium sand in human urine can be caused by (1)eating too much animal protein, (2)eating too much salt, (3)swallowing 1,800mg or more of supplemental calcium per day, and/or (4)swallowing several hundred thousand IUs of vitamin D2 or vitamin D3 in just one day. However, people who eat lots of mushrooms can develop orange-colored calcium sand in their urine after eating much less than 50,000 IU of vitamin D. The reason is that mushrooms contain not only lots of vitamin D2 but also lots of vitamin D1 and lots of vitamin D4. Vitamin D4 has health benefits that all other forms of vitamin D lack. For example, vitamin D4 is prescribed by some medical doctors to increase the amount of calcium circulating in human blood. ... show more
Reviewed in the United States on August 9, 2012 by Ronald M. Chavin
    • Good D
Flavor Name: Unflavored Size: 360 Count (Pack of 1)
Quality product. Good price. Get your Vitamin D going with this.
Reviewed in the United States on February 22, 2026 by Poluka
    • Good Vitamin D3 easy to swallow.
Flavor Name: Unflavored Size: 360 Count (Pack of 1)
This an excellent product. I have been using it for a long time.
Reviewed in the United States on March 5, 2026 by Agustin Ferreiro
    • Good customer service
Flavor Name: Unflavored Size: 360 Count (Pack of 1)
Very good customer service, I purchased a bottle of these and they came all stuck together because a few of them broke open so I contacted their company and sent a picture. They sent a replacement shortly after and it came in good condition. Good strong vitamin d for the price, I take it during the winter because I live in michigan and it helps with my energy and mood. ... show more
Reviewed in the United States on April 12, 2025 by Lisa Howard
    • Good product to take until time to sunbathe
Flavor Name: Unflavored Size: 360 Count (Pack of 1)
I think these work! Have your Vit D check soon. Low Vitamin D can cause a whole host of symptoms. Personally, my body pain is close to non-existent when my vitamin D level stays over 55! It also helps a LOT this time of year with seasonal depression. It really does. Try a supplement like this without soy or fillers. You will thank me. 5000 iu is a maintenance dose for my size. Definitely take a bit more & watch Dr Berg on Vit D if your level is under 50. Also, Magnesium is an amazing co-factor for worth supplementing! ... show more
Reviewed in the United States on December 28, 2025 by Bar T Farm
    • Worth it works
Flavor Name: Unflavored Size: 180 Count (Pack of 1)
Works
Reviewed in the United States on April 3, 2026 by T. F.
    • Good quality product
Flavor Name: Unflavored Size: 180 Count (Pack of 1)
I recently switched from my old brand of Vitamin D3 to the Doctor’s Best as I use another one of their products and like the quality of the items. They have the strength that I need and there is no aftertaste with them. Taking the 5000IU helps keep my Vitamin D levels from dropping, which helps my energy. I’m about halfway through my first bottle and like that the softgels do not stick together. I hadn’t had the same luck with my previous brand. I will be putting them on the subscribe and save so I don’t have to worry about ordering them. ... show more
Reviewed in the United States on November 20, 2025 by Sage

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