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COMFORT ZONE Multi Cat Calming Diffuser Refill, 6 Pack – Cat Calming Pheromone Refills Help Reduce Anxiety, Stress, Scratching, Urine Marking, Multi-Cat Aggression, (30-Day Refills, 180-Day Supply)

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Availability: In Stock.
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Arrives Tuesday, Jun 30
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Size: 6-Pack


Features

  • REDUCE & REUSE: Compatible with Comfort Zone diffusers only; Comfort Zone diffusers are reusable for up to 12 months; just replace the refill monthly for a continuous calming effect
  • TRUSTED & EXPERT RECOMMENDED: Comfort Zone has provided care with cat calming pheromones for over 20 years, making it a trusted choice for pet parents
  • DRUG & FRAGRANCE FREE: Drug-free solution so you can feel good about helping your cat feel good
  • SUBSCRIBE & SAVE FOR 24/7 CALM: Get Comfort Zone delivered on your schedule to help maintain continuous calming support; Save money automatically and skip reordering, to spend time where it matters with your cat;
  • SAVE WITH VALUE PACK: This value pack includes 6 refills, providing up to 6 months of continuous calming support; Use with a Comfort Zone Diffuser to get up to 400 square feet of coverage for 30 days
  • SAFE & TESTED: Meets Intertek electrical safety and certified to UL standards

Description

Comfort Zone Multi-Cat Diffuser Refills are designed to help reduce common signs of stress in homes with multiple cats, supporting calmer interactions and improved behavior. These refills pair with all Comfort Zone cat calming pheromone diffusers and are ideal for cats' everyday stressors like routine changes, new environments, and visitors. When cats share space or compete for territory, tension can lead to unwanted behaviors. A cat plug in pheromone diffuser must be used with this product. Each refill delivers 24/7 calming for up to 30 days, helping maintain a consistent calming environment. The fragrance-free, drug-free pheromone formula mimics a cat’s natural calming pheromones, which cats instinctively recognize as a signal that an area is safe, familiar, and secure. These refills help reduce behaviors commonly associated with cat stress, including urine marking, scratching, swatting, biting, fighting, growling, hissing, spitting, non-playful staring, stalking, chasing, and blocking, which are often seen in multi-cat households. Most cats begin to show improved behavior within as little as one week, with continued benefits through regular use. Each diffuser and refill is designed to cover one room, making it easy to target areas where your cats spend the most time. Easy to use and mess-free, Comfort Zone Multi-Cat Diffuser Refills are expert recommended and tested to meet electrical safety standards, offering peace of mind for everyday use. For best results, plug the diffuser upright in an open area with four feet of clearance around the unit, and avoid placing it under shelves, behind furniture, or near vents or windows. Replace refills monthly to help provide continuous calming support and promote a more comfortable, stress-free home for your cats.

Product Dimensions ‏ : ‎ 5.63 x 3.69 x 3.56 inches; 13.62 ounces


Item model number ‏ : ‎ 100538644


Date First Available ‏ : ‎ January 17, 2019


Manufacturer ‏ : ‎ Central Garden & Pet


Best Sellers Rank: #1,675 in Pet Supplies (See Top 100 in Pet Supplies) #11 in Cat Relaxants


#11 in Cat Relaxants:


Customer Reviews: 4.5 4.5 out of 5 stars (10,597)


Item Weight: 13.6 ounces


Manufacturer: Central Garden & Pet


Item model number: 100538644


Date First Available: January 17, 2019


Item Package Dimensions L x W x H: 5.61 x 3.78 x 3.6 inches


Item Dimensions LxWxH: 5.63 x 3.69 x 3.56 inches


Brand Name: Comfort Zone


Target Audience Keyword: house-cats


Directions: The diffuser gently warms to disperse calming pheromones throughout the room. Plug the diffuser into a wall outlet in an upright position, with the vents pointing toward the ceiling, near where your cat spends the most time. Always keep the diffuser upright—never plug it in upside down, sideways, or into a power strip on the floor. We recommend plugging it into the top outlet to leave the bottom outlet free. The rotatable plug ensures correct placement in any outlet, and an automatic safety shut-off feature helps prevent overheating. Improper use may cause discoloration, increased odor from vapor buildup, or leaking. Use one diffuser per room. Replace the refill about every 30 days and the diffuser unit every 12 months. Only use in fully functioning 120-volt outlets. Leave four feet around diffuser and never plug it under shelves, behind furniture, near vents, or windows.. Store at room temperature Comfort Zone products are developed using over 20 years of experience with cats and are tested by experts in controlled environments and in real homes across a wide range of everyday situations. While we can’t test every individual cat or circumstance, our approach is based on consistent patterns seen in how cats respond to calming pheromones. Results may vary depending on the cat, the environment, and the level of stress. Comfort Zone is designed and intended for situational stress-medical anxiety requires a Veterinarian’s support.


Warranty Description: Satisfaction guaranteed. If you’re not satisfied within 90 days, call us at so we can make it right. Proof of purchase is required.


Model Name: Comfort Zone Multi Cat Calming Diffuser Refills


Size: 6-Pack


Material: Plastic


Age Range Description: All Life Stages


Number of Items: 6


Style: Multi Cat Calming Diffuser


Included Components: 6 Comfort Zone MultiCat Diffuser Refills


Specific Uses for Product: Behavior, Indoor, Urinary Tract Control


Frequently asked questions

If you place your order now, the estimated arrival date for this product is: Tuesday, Jun 30

Yes, absolutely! You may return this product for a full refund within 30 days of receiving it.

To initiate a return, please visit our Returns Center.

View our full returns policy here.

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Top Amazon Reviews


  • We won't go a week without this stuff from now on.
Size: 6-Pack
We have a cat that has some anxiety issues which unfortunately manifest in the form of fights and marking. These absolutely changed his demeanor as well as the relationships between all of our cats. They are so much more docile, affectionate and calm when we have them installed. It's truly a live saver. Reduces indoor marking as well. Easy to use and replace, no odor, you wouldn't know they were there. Very effective. ... show more
Reviewed in the United States on April 3, 2026 by LC

  • Calmed our cat down within weeks, did not make the cat docile. Calmed our cat down within weeks, did not make the cat docile.
Size: 6-Pack
The COMFORT ZONE Multi Cat Calming Diffuser Refill, 6 Pack – Cat Calming Pheromone Refill does exactly what they say it will do. Since we have been using the Comfort Zone calming we have noticed a great improvement in our cats temperament. Prior to getting the Comfort Aon calming we had a big problem with our cat scratching and biting us. Within weeks of installing the Comfort Zone diffusers the cats attitude changed, slowly we saw less biting, and less scratching. Within two months the cat had completely stopped the issues. The Comfort Zone diffusers are not making the cat lethargic or docile, he still runs around, jumps on furniture and couches, but just is a lot more pleasant cat to have in the house. He even now plays with our occasional Great Dane visitor, no claws but smacks the much larger visitor make sure the Great Dane knows he is the boss. We have a long house so we have one at each end of the house, one by his food, and another by his second litter tray. ... show more
Reviewed in the United States on April 5, 2026 Reviewed in the United States on April 5, 2026 by TisBrian

  • Seems to work for my Wild Ones, can be a little messy but Worth it if it works for your Cats.
Size: 6-Pack
I am careful with these, and have begun to wear gloves as they can leak and get on you when installing. Comfort Zone seems to calm down the crazier of my fully hand raised furbabies, so I've been using it for awhile... they are getting to be full adults now, more mature, and I'm hoping to wean them off of it sometime in the future. Cats are crazy. Compare all the options for bases and refills and look for the best deals as some seemed to be more affordable than others. Subscribe and save has worked well for me here. ... show more
Reviewed in the United States on June 28, 2025 by Xela

  • This is the greatest product I have found for my cat's
Size: 6-Pack
I have two cats, Olive, Trouble Under Foot, and believe me he is. Oli is part Russian blue and part Schizophrenic. Sophie Grace is part Main Coon and Petrified Sweetheart. Sophie is still afraid of us after 5 years. It breaks my heart to think of what happened to her before her 8 weeks when we got her. Sophie has tolerated Oliver, but they are not best friends. Oli would like to be an only cat and he does his best to get rid of Sophie, (it’s not going to happen). He takes Sophie’s blanket from their room and hauls it to the laundry or to the trash in the kitchen, he eats her food and will push her out of the way if she is sitting in her favorite spot in the window. They got along reasonably well until Oli had to have some teeth pulled. He was so angry when he came home, he took it out on Sophie. I had to separate them for a few days, and I was in a panic mode trying to figure out what I could do to calm him down. The Vet told me to get a Pheromone product and that should help. On-line I found several products that were very insightful and after much review I chose Comfort Zone. This product is amazing, it calmed Oli down and he was no longer screaming every time he saw Sophie and it helped her nervous little body to calm down. At first, I purchased one Comfort Zone to give it a try and put it in my office. I noticed that both cats were in the same room and not fighting. I couldn’t wait to order 6 more. I have them upstairs and downstairs and two in their room and we are back to a calm house. Well, Oli would still like me to get rid of Sophie, he is still very jealous of her and resents me giving her attention, however, Oli is no longer dragging her blanket out of their room. I HIGHLY RECOMMEND COMFORT ZONE. It has saved our peaceful home from a constant battle. Now, both cats are sitting in the window together! I am sorry I didn’t find Comfort Zone 5 years ago This product is a game changer. ... show more
Reviewed in the United States on July 19, 2024 by Sam

  • Duel packs working better than bulk oddly.
Size: 2 pack
I am having the odd experience the last couple orders of the packages with two Comfort zones working far better than Feliway or the comfort zone multi packs. Working so much better our indoor outdoor cat is sleeping on our bed everyday for the first time & other cat isn't wailing all hours of the night! ( I have one in the bedroom and one in the living room) Even trying other products they did not work as well. Some had chemical burning smell. There has been some leakage which is always a bummer and they rarely last a whole month but I cannot do without. I feel these products are highly over priced across the board unfortunately taking advantage of our love of our animals. ... show more
Reviewed in the United States on November 16, 2025 by Marianne

  • Worth the money
Size: 6-Pack
It works. I live in a rat and mouse infested apartment building. I feel like I need this stuff just as much as my cat! He was terrified and I believe he was attacked at one point several months ago. I cannot afford to move anywhere. I can afford this though. I wish that I could afford to buy enough so that every single electric outlet could have one. ... show more
Reviewed in the United States on March 10, 2026 by Dawn Marie

  • Love the product, came empty this time around. Love the product, came empty this time around.
Size: 2 pack
Came empty, leaked through the box onto all of my other items.
Reviewed in the United States on April 15, 2026 Reviewed in the United States on April 15, 2026 by courtney fink

  • Reccomend
Size: 6-Pack
This really helped my rescued cats relax. They still don't love each other, but they're doing much better
Reviewed in the United States on June 9, 2026 by Kb

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