Search  for anything...
Comfort Zone

Comfort Zone Multi Cat Calming Diffuser Refill, 6 Pack

  • Based on 10,658 reviews
Condition: New
Checking for the best price...
$59.99 Why this price?

Buy Now, Pay Later

As low as $10.00 / mo
  • – 6-month term
  • – No impact on credit to apply
  • – Instant approval decision
  • – Secure and straightforward checkout

Ready to go? Add this product to your cart and select a plan during checkout.

Payment plans are offered through our trusted finance partners Klarna, Affirm, Afterpay, Zip, Apple Pay, and Google Pay. No-credit-needed leasing options through Acima may also be available at checkout.

Learn more about financing & leasing here.

Selected Option

Free shipping on this product

FREE 30-day refund/replacement

To qualify for a full refund, items must be returned in their original, unused condition. If an item is returned in a used, damaged, or materially different state, you may be granted a partial refund.

To initiate a return, please visit our Returns Center.

View our full returns policy here.

Availability: In Stock.
Fulfilled by Amazon
Arrives Saturday, Aug 29
Order within 1 hour and 21 minutes
Available payment plans shown during checkout
Protection Plan Protect Your Purchase
Checking for protection plans...

Recently Viewed

Size: 6-Pack


Features

  • REDUCE & REUSE: Cat pheromones calming diffuser refill is compatible with Comfort Zone diffusers only. Comfort Zone diffusers are reusable for up to 12 months; just replace the refill monthly for a continuous calming effect
  • TRUSTED & EXPERT RECOMMENDED: Comfort Zone pheromone diffuser to calm cats has provided care with cat calming pheromones for over 20 years, making it a trusted choice for pet parents
  • DRUG & FRAGRANCE FREE: Comfort Zone cat calming diffuser refills provide a drug-free solution so you can feel good about helping your cat feel good
  • SUBSCRIBE & SAVE FOR 24/7 CALM: Get Comfort Zone get cat calming products delivered on your schedule to help maintain continuous calming support; Save money automatically and skip reordering, to spend time where it matters with your cat
  • SAVE WITH VALUE PACK: This value pack includes 6 refills, providing up to 6 months of continuous calming cat essentials for calming support; Use with a Comfort Zone Diffuser to get up to 400 square feet of coverage for 30 days
  • SAFE & TESTED: This calming cat diffuser meets Intertek electrical safety and certified to UL standards

Description

Comfort Zone Multi-Cat Diffuser Refills are designed to help reduce common signs of stress in multi-cat homes and households with multiple cats, supporting calmer interactions, cat stress relief, stress reduction, and improved cat behavioral aid. These pet care essentials are a must-have for cat owners and pair with all Comfort Zone cat calming pheromone diffusers - ideal for indoor cats and their everyday stressors like routine changes, new environments, and visitors. A cat plug in pheromone diffuser must be used with this product.Each refill delivers 24/7 calming for up to 30 days for everyday use indoors, helping maintain a consistent calming environment for indoor cats in multi-cat homes. The fragrance-free, drug-free pheromone formula mimics a cat's natural calming pheromones, which cats instinctively recognize as a signal that an area is safe, familiar, and secure. These refills help reduce behaviors including urine marking, scratching, swatting, biting, fighting, growling, hissing, and blocking. Most cats begin to show improved behavior within as little as one week, with continued stress reduction benefits through regular use.Each refill is designed to cover one room in an open area, and for best results avoid placing under shelves, behind furniture, or near vents or windows. Easy to use and mess-free, Comfort Zone Multi-Cat Diffuser Refills are expert recommended and tested to meet electrical safety standards, offering peace of mind for cat owners in households with multiple cats. Replace refills monthly for continuous calming support and a more comfortable, stress-free home.

Product Dimensions ‏ : ‎ 5.63 x 3.69 x 3.56 inches; 13.62 ounces


Item model number ‏ : ‎ 100538644


Date First Available ‏ : ‎ January 17, 2019


Manufacturer ‏ : ‎ Central Garden & Pet


Best Sellers Rank: #2,128 in Pet Supplies (See Top 100 in Pet Supplies) #14 in Cat Relaxants


#14 in Cat Relaxants:


Customer Reviews: 4.5 4.5 out of 5 stars (10,658)


Item Weight: 13.6 ounces


Manufacturer: Central Garden & Pet


Item model number: 100538644


Date First Available: January 17, 2019


Item Package Dimensions L x W x H: 5.61 x 3.78 x 3.6 inches


Item Dimensions LxWxH: 5.63 x 3.69 x 3.56 inches


Brand Name: Comfort Zone


Target Audience Keyword: house-cats


Directions: The diffuser gently warms to disperse calming pheromones throughout the room. Plug the diffuser into a wall outlet in an upright position, with the vents pointing toward the ceiling, near where your cat spends the most time. Always keep the diffuser upright—never plug it in upside down, sideways, or into a power strip on the floor. We recommend plugging it into the top outlet to leave the bottom outlet free. The rotatable plug ensures correct placement in any outlet, and an automatic safety shut-off feature helps prevent overheating. Improper use may cause discoloration, increased odor from vapor buildup, or leaking. Use one diffuser per room. Replace the refill about every 30 days and the diffuser unit every 12 months. Only use in fully functioning 120-volt outlets. Leave four feet around diffuser and never plug it under shelves, behind furniture, near vents, or windows.. Store at room temperature Comfort Zone products are developed using over 20 years of experience with cats and are tested by experts in controlled environments and in real homes across a wide range of everyday situations. While we can’t test every individual cat or circumstance, our approach is based on consistent patterns seen in how cats respond to calming pheromones. Results may vary depending on the cat, the environment, and the level of stress. Comfort Zone is designed and intended for situational stress-medical anxiety requires a Veterinarian’s support.


Warranty Description: Satisfaction guaranteed. If you’re not satisfied within 90 days, call us at so we can make it right. Proof of purchase is required.


Model Name: Comfort Zone Multi Cat Calming Diffuser Refills


Size: 6-Pack


Material: Plastic


Age Range Description: All Life Stages


Number of Items: 6


Style: Multi Cat Calming Diffuser


Included Components: 6 Comfort Zone MultiCat Diffuser Refills


Specific Uses for Product: Behavior, Indoor, Urinary Tract Control


Frequently asked questions

If you place your order now, the estimated arrival date for this product is: Saturday, Aug 29

Yes, absolutely! You may return this product for a full refund within 30 days of receiving it.

To initiate a return, please visit our Returns Center.

View our full returns policy here.

  • Klarna Financing
  • Affirm Pay in 4
  • Affirm Financing
  • Afterpay Financing
  • Zip Pay in 4
  • Financing through Apple Pay
  • Financing through Google Pay
Leasing options through Acima may also be available during checkout.

Learn more about financing & leasing here.

Similar Products

Top Amazon Reviews

    • Not a miracle cure, but definitely work
Size: 6-Pack
I have been using this product for a year now. We have a two story house and have one upstairs and one downstairs. You do not smell anything from it first off. I have three adult male cats and one very shy female. This is not a fix all and does not work some miracle with them. However we will continue to purchase this and keep them in the home. While it’s not a huge or drastic change we always do know when it’s out and time to replace it. My cats don’t pee in places they are not supposed to, so I am not sure how it changes that specific behavior. But our very shy girl is out and more active and adventurous when we have these. That is one big difference we see. The boys still tussle but it’s a very obvious play fight, it’s not always just play when these run out. The cat zoomies still happen but they are not as hardcore parcore as they are when we don’t have these plugged in. In short, yes they work, yes we see a difference in all 4 cats. But it’s a slight adjustment to their behavior and not something that makes them do a 180. None of the our cats seem bothered by them so I feel safe with this product when it comes to their scent sensitivity. They are super easy to use and just twist in and out. Hope this helps any other cat parents out there who want a fully honest review. And again we have had these in our home for over a year now. ... show more
Reviewed in the United States on June 22, 2026 by Elle Jacobs
    • This is the greatest product I have found for my cat's
Size: 6-Pack
I have two cats, Olive, Trouble Under Foot, and believe me he is. Oli is part Russian blue and part Schizophrenic. Sophie Grace is part Main Coon and Petrified Sweetheart. Sophie is still afraid of us after 5 years. It breaks my heart to think of what happened to her before her 8 weeks when we got her. Sophie has tolerated Oliver, but they are not best friends. Oli would like to be an only cat and he does his best to get rid of Sophie, (it’s not going to happen). He takes Sophie’s blanket from their room and hauls it to the laundry or to the trash in the kitchen, he eats her food and will push her out of the way if she is sitting in her favorite spot in the window. They got along reasonably well until Oli had to have some teeth pulled. He was so angry when he came home, he took it out on Sophie. I had to separate them for a few days, and I was in a panic mode trying to figure out what I could do to calm him down. The Vet told me to get a Pheromone product and that should help. On-line I found several products that were very insightful and after much review I chose Comfort Zone. This product is amazing, it calmed Oli down and he was no longer screaming every time he saw Sophie and it helped her nervous little body to calm down. At first, I purchased one Comfort Zone to give it a try and put it in my office. I noticed that both cats were in the same room and not fighting. I couldn’t wait to order 6 more. I have them upstairs and downstairs and two in their room and we are back to a calm house. Well, Oli would still like me to get rid of Sophie, he is still very jealous of her and resents me giving her attention, however, Oli is no longer dragging her blanket out of their room. I HIGHLY RECOMMEND COMFORT ZONE. It has saved our peaceful home from a constant battle. Now, both cats are sitting in the window together! I am sorry I didn’t find Comfort Zone 5 years ago This product is a game changer. ... show more
Reviewed in the United States on July 19, 2024 by Sam
    • It does make a huge difference!
Size: 6-Pack
Review Image by F.W.
I have been using this product for over a year and can say with full confidence the formula itself works great. I have an older cat with cerebellar hypoplasia and some other health issues along with two kittens under a year old. My older boy is a crotchety old man who hates everyone and everything and growls at the kittens if they enter the same room as him. Whenever I see his behavior getting worse, I check the pheromone thingy and sure enough it'll be empty. I just put a fresh one on last night and caught him actually being nice to one of the babies today!!! It works miracles. Only negatives are that the refills fit very loosely on the plug in, and will even fall off. Maybe I got a dud plugin though. It also gets really greasy on the outside and dusty/hairy while getting very warm, so make sure it's kept clean. Again, maybe I got a bad plugin and a new one wouldn't have these issues, but it's so expensive I'm not buying a new one. Very pricey, but I won't live without one while I've got these sassy boys in the same house! ... show more
Reviewed in the United States on August 28, 2024 by F.W.
    • Amazing
Size: 2 pack
Works great. Introduced my male cat to my female and it only took 2 days and they were fine together. Now they are best buds
Reviewed in the United States on July 12, 2026 by karen
    • Calmed our cat down within weeks, did not make the cat docile.
Size: 6-Pack
Review Image by TisBrian
Review Image by TisBrian
Review Image by TisBrian
Review Image by TisBrian
The COMFORT ZONE Multi Cat Calming Diffuser Refill, 6 Pack – Cat Calming Pheromone Refill does exactly what they say it will do. Since we have been using the Comfort Zone calming we have noticed a great improvement in our cats temperament. Prior to getting the Comfort Aon calming we had a big problem with our cat scratching and biting us. Within weeks of installing the Comfort Zone diffusers the cats attitude changed, slowly we saw less biting, and less scratching. Within two months the cat had completely stopped the issues. The Comfort Zone diffusers are not making the cat lethargic or docile, he still runs around, jumps on furniture and couches, but just is a lot more pleasant cat to have in the house. He even now plays with our occasional Great Dane visitor, no claws but smacks the much larger visitor make sure the Great Dane knows he is the boss. We have a long house so we have one at each end of the house, one by his food, and another by his second litter tray. ... show more
Reviewed in the United States on April 5, 2026 by TisBrian
    • We won't go a week without this stuff from now on.
Size: 6-Pack
We have a cat that has some anxiety issues which unfortunately manifest in the form of fights and marking. These absolutely changed his demeanor as well as the relationships between all of our cats. They are so much more docile, affectionate and calm when we have them installed. It's truly a live saver. Reduces indoor marking as well. Easy to use and replace, no odor, you wouldn't know they were there. Very effective. ... show more
Reviewed in the United States on April 3, 2026 by LC
    • Great product, but might arrive leaking
Size: 6-Pack
Review Image by Bret A.
Review Image by Bret A.
I swear by this product for my household. I have 5 kitties and I know exactly when the plugins are getting low because everyone starts acting up. This is my go-to when recommending a product to friends. My biggest complaint though is that there isn't any kind of seal on the manufacturer's cap, so they will leak everywhere if Amazon packs them upside down or on their sides (literally has "this side up" markers on the box!) This has happened a few times in the past (I've been using this product for years), but the last two orders I've received have just been an absolutely oily mess. This stuff isn't cheap so I don't appreciate not getting to use every ounce I paid for. ... show more
Reviewed in the United States on June 29, 2026 by Bret A.
    • Reccomend
Size: 6-Pack
This really helped my rescued cats relax. They still don't love each other, but they're doing much better
Reviewed in the United States on June 9, 2026 by Kb

Can't find a product?

Find it on Amazon first, then paste the link below.
Checking for best price...