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Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 2-Month Supply

  • Based on 33,135 reviews
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Availability: In Stock.
Fulfilled by Amazon

Arrives Wednesday, Nov 12
Order within 20 hours and 59 minutes
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Size: 2-Pack


Style: Large Cat only


Features

  • Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
  • Vet-recommended, easy-to-apply monthly topical treatment no hard-to-swallow pills, no prescription needed
  • Delivers total flea protection kills adult fleas, flea larvae and flea eggs through contact
  • Same-day effectiveness kills fleas within 12 hours of application and keeps working for 30 days
  • Fragrance-free formula, waterproof after 24 hours of application

Description

Advantage II Large Cat is a vet-recommended, leading brand in cat flea protection. Advantage II Large Cat flea treatment and prevention kills adult fleas, flea larvae and flea eggs to deliver total flea protection to your cat or kitten. Within 12 hours of application, Advantage II Large Cat topical treatment gets straight to work killing fleas through contact, so they don’t have to bite your cat to die. This treatment works hard for 30 days following application, effectively breaking the flea life cycle, controlling existing flea infestations and preventing further infestations all month long.Fleas not only cause discomfort; they can also pose other health risks. Monthly use of Advantage II Large Cat is important to protect your cat against fleas that may cause transmission of tapeworms, Flea Allergy Dermatitis and flea bite anemia.That’s why Advantage II Large Cat makes applying treatment simple. This convenient, spot-on application goes on the back of your cat’s neck at the base of the skull. You’ll simply place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. It goes on in seconds! It's easier than a flea collar and there are no hard-to-swallow pills. You’ll also love that Advantage II Large Cat is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects.Advantage II Large Cat flea protection is effective on both indoor and outdoor cats. Your cat should be at least 8 weeks old and weigh over 9 lbs. to use Advantage II Large Cat.For the ultimate convenience in care, Advantage II Large Cat is available over the counter – no prescription needed. And, you can stock up with a subscription for regular doorstep deliveries so you never miss a monthly treatment. Advantage II Large Cat is a trademark of Elanco or its affiliates.

Brand: Advantage


Item Form: Topical


Scent: Unscented


Item Weight: 0.04 Pounds


Active Ingredients: Imidacloprid, Pyriproxyfen


Item Volume: 1.6 Milliliters


Allergen Information: Allergen-Free


Dog Breed Size: Large


Age Range (Description): 8 weeks and older


UPC:


Is Discontinued By Manufacturer ‏ : ‎ No


Product Dimensions ‏ : ‎ 1 x 4.38 x 4.75 inches; 0.64 ounces


Item model number ‏ : ‎ 86336677


Date First Available ‏ : ‎ September 1, 2014


Manufacturer ‏ : ‎ Elanco US Inc


Best Sellers Rank: #94 in Pet Supplies (See Top 100 in Pet Supplies) #1 in Cat Flea Drops


#1 in Cat Flea Drops:


Customer Reviews: 4.5 4.5 out of 5 stars 33,135 ratings


Item Weight: 0.64 ounces


Manufacturer: Elanco US Inc


Item model number: 86336677


Date First Available: September 1, 2014


Item Package Dimensions L x W x H: 10.75 x 4.69 x 1.06 inches


Item Dimensions LxWxH: 1 x 4.38 x 4.75 inches


Item Weight: 0.04 Pounds


Brand Name: Advantage


Target Audience Keyword: house-cats


Directions: Application Instructions 1. Use only on cats. 2. Hold applicator tube in an upright position. Pull cap off tube. 3. Turn the cap around and place other end of cap back on tube. Twist cap to break seal, then remove cap from tube. 4. Part the hair at the base of the cat’s skull until skin is visible. 5. Evenly apply the entire contents of the Advantage II tube directly on the skin by squeezing the entirety of the contents in that one spot. Do not get this product in your cat’s eyes, or allow your cat to ingest this product.


Country of Origin: Germany


Model Name: Advantage II


Color: Large Cat only


Size: 2-Pack


Age Range Description: 8 weeks and older


Number of Items: 1


Style: Large Cat only


Breed Recommendation: Large


Specific Uses for Product: Parasites


Frequently asked questions

No, the Advantage II is specifically designed for large cats over 9 pounds. For smaller cats or kittens, it's suggested to use a different variation of Advantage.

This package provides a 2-month supply. It's recommended to apply the treatment monthly for continuous flea protection.

Yes, Advantage II for Large Cats is a vet-recommended flea treatment and prevention product.

Advantage II works by killing fleas through contact, meaning they don’t have to bite your cat to die. It kills fleas within 12 hours of the first application and prevents further flea infestations for up to a month.

Top Amazon Reviews

🚀 Abunda's Overview

This is our summary and key points to consider based on customer reviews.


Advantage II Large Cat is a well-reviewed flea treatment for cats over nine pounds. It efficiently kills adult fleas, their larvae, and eggs, causing a significant reduction in flea infestations within days. The formula, which is applied topically, begins working in twelve hours and is effective for thirty days. It is praised for its ease of use, as no prescription is needed, and for its effectiveness, even in comparison to more expensive brands.

Pros

  • 👍 Highly effective in eliminating fleas
  • 🐱 Designed specifically for large cats over nine pounds
  • 🏥 No need for a vet's prescription
  • ⏰ Begins working in 12 hours, provides protection for 30 days
  • 💦 Easy to apply and dries quickly

Cons

  • 👃 Has a slightly "chemical" smell, although it dissipates once dried
  • 💲 May seem a bit expensive, but users agree the effectiveness justifies the cost

Should I Buy It?

Based on the overwhelmingly positive reviews and the effectiveness of the product, even in severe infestations, purchasing Advantage II Large Cat flea treatment appears to be a wise decision. The product works fast, keeps working for a month, and requires no prescription. Despite a slightly chemical smell and a higher price range, it is dramatically effective and often outperforms more expensive brands. If flea treatment for large cats is what you need, this product is highly recommended.


  • Reliable Flea Protection That Works Quickly
Size: 4-Pack Style: Large Cat only
I’ve been using Advantage II for my large cat (over 12 lbs), and it’s the only flea treatment I fully trust. Within just a day of applying it, I noticed a big difference—scratching stopped, and I wasn’t finding fleas on her bedding anymore. By the second day, the fleas were completely gone. Application is simple: just part the fur at the base of the neck and apply directly to the skin. My cat tolerates it well, and the formula dries quickly without leaving a greasy mess. I also appreciate that it’s waterproof after 24 hours, so I don’t have to worry if she gets into a little rain or needs a bath. The 4-month supply is cost-effective compared to buying single doses, and I like knowing I can stay ahead of any infestations. This product really delivers on prevention as well—no fleas have come back in between monthly doses. If you have a bigger cat and need something safe, effective, and vet-recommended, this is an excellent choice. It gives peace of mind and keeps both your cat and your home flea-free. Highly recommend! ... show more
Reviewed in the United States on August 22, 2025 by tara speece

  • Die, fleas, die!
Size: 2-Pack Style: Large Cat only
Crazy fast flea killer! My poor Oreo got infested with fleas from my neighbor's apartment. She's an indoor cat and I've never had to treat her for ticks or fleas. Suddenly, she was itching furiously and I thought it was dry skin. I brushed her and was horrified to see that fleas were crawling all over Oreo. Everything was closed so I checked Amazon and Advantage II was available in just hours. I probably paid more by not buying it from Walmart, but pets are worth the extra cost. It was delivered quickly, as promised, and it worked quickly, also as promised. Today, less than 48 hours later, I'm brushing Oreo, who stopped scratching, and the only thing in the brush (besides fur) are dead flea pieces. I'm very leery about using harsh chemicals on my pets. I once used Frontline on one of my cats and she immediately became sick and died a few months later. Oreo is back to her honery, hateful self and Advantage II saved my apartment from having a major infestation. ... show more
Reviewed in the United States on October 27, 2025 by laura nicewaner laura nicewaner

  • It works ,its awesome ,worked when nothing else would
Size: 2-Pack Style: Large Cat only
It kills fleas Advantage 2 for cats , nothing helped until I found it and pared it with Harris bed bugs killer and flea killer plus Advantage 2in combo the fleas was gone in three months after a week or two spray again for the hatching eggs ,the advantage 2 kills them on contact ,if the flea bites your cat the fleas dies awesome stuff why ? Because it works ... show more
Reviewed in the United States on October 25, 2025 by MissB

  • glad my vet recommended this - so far
Size: 2-Pack Style: Large Cat only
just giving 4 stars for now because it's only been a weekend. i want to see if this is long lasting and i'll come back with update. but for my use of it, it was fairly easy, i put the liquid in the back of neck between shoulder blades and let it doe it's work. so far my indy is very comfy. i used this in conjunction with capstar, and used a good premise spray for the house. so far the combo seems to be working. this was all recommended by my vet - so i'm glad i reached out because the other product i bought in petco did not work much longer than a day. ... show more
Reviewed in the United States on September 7, 2025 by S. Police

  • So far so good
Size: 2-Pack Style: Large Cat only
My dogs and cats got hit with fleas at the same time. I bought K9 Advantix, as well as the Feline Advantix. The K9 Advantix did not work and my dogs are back to itching. The cat Advantix however appears to have worked and the cats are not itching like the dogs.
Reviewed in the United States on September 10, 2025 by Andrew

  • Keeps My Cats Healthy and Flea-Free!
Size: 4-Pack Style: Large Cat only
I’ve been using this flea treatment for about six months now on my two female cats (around 11 lbs each), and it’s worked perfectly. They’re mostly indoor kitties but go in the backyard sometimes, so I use this to prevent fleas and worms. I apply it directly to the back of their necks—it’s easy to use and very effective. The only tricky part is that my cats don’t like the smell and try to run away, so you have to be quick when applying it! The greasy spot it leaves on the area applied only lasts about a day and then clears up on its own. My cats stay healthy, happy, and completely flea-free. ... show more
Reviewed in the United States on October 13, 2025 by Kat Kat

  • Worked!
Size: 2-Pack Style: Large Cat only
We have been fighting fleas in our home for a year now and we bought this treatment and it is the first one that has actually fully worked. We paired it with a flea collar and have can happily say we no longer have a flea problem. Our cats are a little under 9lbs but still purchased the treatment for cats 9lbs and over. ... show more
Reviewed in the United States on October 21, 2025 by Meleah Mitchell

  • Works most of the time
Size: 2-Pack Style: Large Cat only
Works sometimes
Reviewed in the United States on October 26, 2025 by Placeholder

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