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Advantage

Advantage II Large Cat Topical Flea Treatment & Prevention, 2ct

  • Based on 81,368 reviews
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Size: 2-Pack


Features

  • MONTHLY CAT FLEA TREATMENT: This vet-recommended* flea topical for cats treats and prevents flea infestations on cats for one month *Elanco Animal Health. Data on file. REF-23987
  • BREAKS THE FLEA LIFECYCLE: This flea topical for cats provides 3-way protection against adult fleas, flea larvae, and flea eggs, effectively breaking the flea lifecycle
  • FOR CATS OVER 9 POUNDS: Advantage Large II Cat can be used on cats 8 weeks of age and older, weighing over 9 lbs; also available for kittens 2-5 lbs. and small cats 5-9 lbs.
  • SAME DAY EFFECTIVENESS: This monthly flea topical for cats kills fleas on cats within 12 hours of application, and it kills reinfesting fleas on cats within 2 hours
  • WORKS THROUGH CONTACT: Advantage II Cat kills fleas through contact, so they don't have to bite your cat to die

Description

Advantage II Large Cat is a vet-recommended, leading brand in cat flea protection. Advantage II Large Cat flea treatment and prevention kills adult fleas, flea larvae and flea eggs to deliver total flea protection to your cat or kitten. Within 12 hours of application, Advantage II Large Cat topical treatment gets straight to work killing fleas through contact, so they donā€™t have to bite your cat to die. This treatment works hard for 30 days following application, effectively breaking the flea life cycle, controlling existing flea infestations and preventing further infestations all month long.Fleas not only cause discomfort; they can also pose other health risks. Monthly use of Advantage II Large Cat is important to protect your cat against fleas that may cause transmission of tapeworms, Flea Allergy Dermatitis and flea bite anemia.Thatā€™s why Advantage II Large Cat makes applying treatment simple. This convenient, spot-on application goes on the back of your catā€™s neck at the base of the skull. Youā€™ll simply place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. It goes on in seconds! It's easier than a flea collar and there are no hard-to-swallow pills. Youā€™ll also love that Advantage II Large Cat is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects.Advantage II Large Cat flea protection is effective on both indoor and outdoor cats. Your cat should be at least 8 weeks old and weigh over 9 lbs. to use Advantage II Large Cat.For the ultimate convenience in care, Advantage II Large Cat is available over the counter ā€“ no prescription needed. And, you can stock up with a subscription for regular doorstep deliveries so you never miss a monthly treatment. Advantage II Large Cat is a trademark of Elanco or its affiliates.

Brand: Advantage


Item Form: Drops


Scent: Unscented


Item Weight: 22.68 g


Active Ingredients: Imidacloprid, Pyriproxyfen


Item Volume: 1.6 ml


Allergen Information: Allergen-Free


Dog Breed Size: Large


Unit Count: 2 Count


Color: Large Cat only


Product Dimensions ā€ : ā€Ž 1 x 4.38 x 4.75 inches; 0.8 ounces


Manufacturer recommended age ā€ : ā€Ž 1 month and up


Item model number ā€ : ā€Ž 86336677


Date First Available ā€ : ā€Ž June 13, 2014


Manufacturer ā€ : ā€Ž Elanco US Inc


Best Sellers Rank: #81 in Pet Supplies (See Top 100 in Pet Supplies) #1 in Cat Flea Drops


#1 in Cat Flea Drops:


Customer Reviews: 4.5 4.5 out of 5 stars (81,368)


Brand Name: Advantage


Unit Count: 2 Count


Age Range Description: 8 weeks and older


UPC: 884989471941 724089202246 724089682512


Global Trade Identification Number: 12


Item Type Name: Topical


Manufacturer: Elanco US Inc


Model Number: 86336677


Manufacturer Part Number: 86336677


Item Form: Drops


Scent Name: Unscented


Dog Breed Size: Large


Target Species: Cat


Item Weight: 22.68 g


Volume: 1.6 ml


Allergen Information: Allergen-Free


Active Ingredients: Imidacloprid, Pyriproxyfen


Frequently asked questions

No, the Advantage II is specifically designed for large cats over 9 pounds. For smaller cats or kittens, it's suggested to use a different variation of Advantage.

This package provides a 2-month supply. It's recommended to apply the treatment monthly for continuous flea protection.

Yes, Advantage II for Large Cats is a vet-recommended flea treatment and prevention product.

Advantage II works by killing fleas through contact, meaning they donā€™t have to bite your cat to die. It kills fleas within 12 hours of the first application and prevents further flea infestations for up to a month.

Similar Products

Top Amazon Reviews

šŸš€ Abunda's Overview

This is our summary and key points to consider based on customer reviews.

Advantage II Large Cat is a well-reviewed flea treatment for cats over nine pounds. It efficiently kills adult fleas, their larvae, and eggs, causing a significant reduction in flea infestations within days. The formula, which is applied topically, begins working in twelve hours and is effective for thirty days. It is praised for its ease of use, as no prescription is needed, and for its effectiveness, even in comparison to more expensive brands.

Pros

  • šŸ‘ Highly effective in eliminating fleas
  • šŸ± Designed specifically for large cats over nine pounds
  • šŸ„ No need for a vet's prescription
  • ā° Begins working in 12 hours, provides protection for 30 days
  • šŸ’¦ Easy to apply and dries quickly

Cons

  • šŸ‘ƒ Has a slightly "chemical" smell, although it dissipates once dried
  • šŸ’² May seem a bit expensive, but users agree the effectiveness justifies the cost

Should I Buy It?

Based on the overwhelmingly positive reviews and the effectiveness of the product, even in severe infestations, purchasing Advantage II Large Cat flea treatment appears to be a wise decision. The product works fast, keeps working for a month, and requires no prescription. Despite a slightly chemical smell and a higher price range, it is dramatically effective and often outperforms more expensive brands. If flea treatment for large cats is what you need, this product is highly recommended.

    • IT WORKS! 24 hours after application and NO LIVE FLEAS.
Size: 1-Pack
Review Image by Verified Amazon Customer
Review Image by Verified Amazon Customer
Review Image by Verified Amazon Customer
Review Image by Verified Amazon Customer
I like to know things. One question I had was how in the *#*@ does an indoor cat get fleas? I looked it up and it's a lot more common that one might think. Fleas are jumpy little things that find their way onto shoes, clothing, and other things people bring home with them. Unless one never leaves their house, there's a very good chance of bringing fleas in with you without ever knowing. Long story short, once I noticed the fleas, I took steps to get it under control. A flea comb is essential! My vet recommended a topical, so I spent the big money and went with a FRONT of the LINE solution. It was supposed to be the best in the biz. I followed the directions and it did absolutely **nothing** for my cat. I was still combing live fleas out of her by the hundreds. It was a total waste of money. A week later I applied another dose of the FRONT of the LINE topical. Again, it did absolutely **nothing** for her. After which, I tried a flea spray to no advantage. She hated it, it smelled terrible, and because she hated it, I couldn't get it far enough into her long fur for it to do any good. We ended up using the spray on our furniture and her carpets. We did NOT want to put her in the bathtub. I mean, if you've ever bathed a cat in less than a full suit of armor, you know what I'm talking about. I purchased a dry flea & tick shampoo along with the same brand of spray. The waterless flea bath "does" kill fleas after a few seconds in the foam, but she hated it so much her behavior changed drastically. Drastically enough that it scared the crap out of me. She stopped coming in the living room, stopped perching on the back of my chair, wouldn't jump on me for cuddles, was lethargic, and stopped sleeping on my chest after I went to bed. She wasn't acting like herself. At. All. That said, I was still combing live fleas out by the dozens. That number would have been a lot higher but since she was already not acting like herself, I didn't want to stress her out even more by doing more combing. Enter Advantage II Large Cat. I always do a lot of research before using a new product. I had seen the nightmare reviews of skin burns and worse. Even so, there were a lot more good reviews than bad...and I was getting desperate. Using the Advantge II Large Cat was my 2nd to last resort. IF it didn't work, she was going to get a water bath...and I don't have a suit of armor. I was looking as forward to doing that as I would look forward to dragging my body over razor wire...which is essentially the same thing. I am very happy, thrilled in fact, to report that this product worked beautifully! I properly applied the product on 10/29/25 at 3pm. I was very careful to make sure I parted her long fur enough for it to get on her skin. The product takes a full 12 hours to reach is max potency. After 12 hours, I was coming less live fleas from her. It is now 10/31/25 and at last combing, there were NO live fleas. Zero. Ziltch. Nada. Her behavior is returning to normal, she's not scratching/biting like a little banshee anymore, and she had no adverse reactions to the product. I will continue to be diligent with the flea comb to see if she needs another treatment next week. Knowing what I know now, I wish I wouldn't have wasted my money on the FRONT of the LINE solution and used Advantage II Large Cat from the get go. I could have saved my cat and myself a lot of undo stress and worry. I highly recommend this product. Note: If one is worried about their cat's skin, I recommend using one or two drops to "test" how your cat will react to it before giving the full dose. ... show more
Reviewed in the United States on October 31, 2025 by Verified Amazon Customer
    • Fast relief for stressed out cats and tired owners.
Size: 1-Pack
TL;DR: Works quickly, easy to use, and stopped a full flea flare up in a day without turning it into a huge chore. We grabbed this during a sudden little outbreak, and I was honestly relieved at how simple it was to use. The tube opens cleanly without splattering, and the liquid goes right onto the skin without any fighting or trying to part the fur forever. Our big cat barely reacted, which made the whole thing easier. What stood out most, though, was how fast it worked. By the next day, the scratching had almost completely stopped, and the fleas we saw earlier were gone. Thereā€™s something comforting about using a product that doesnā€™t need tricks or follow up treatments right away. It just gets in there, does the job, and lets the whole house calm down again. I also appreciate that itā€™s unscented. No strong chemical smell lingering on the cat or in the room. As the days went on, the difference stayed steady. No more tiny specks showing up, no more frantic grooming, and the cat settled right back into normal behavior. It didnā€™t irritate his skin or leave any oily patch that lingered forever, which sometimes happens with other treatments. This one soaked in cleanly and didnā€™t bother him at all. Having something that clears things up fast is a huge help when youā€™re juggling pets, kids, and everything else. It feels like a reliable tool you keep on hand just in case, and itā€™s reassuring knowing youā€™re using something vet recommended with ingredients that have been around for years. Thereā€™s a good sense of trust that comes with that. What I like most is the peace of mind afterward. Once it kicked in, the whole flea situation was just done, and that kind of quick resolution is worth a lot. Itā€™s the kind of product youā€™re grateful to have on hand before a problem turns into a bigger headache. Tip: Apply it when your cat is relaxed and already settled so the dose goes on smoothly without any twisting or fussing. Don't let them flick their head and splash it in your eyes! Hope this helps! =) ... show more
Reviewed in the United States on December 7, 2025 by Thraddash
    • A must buy!
Size: 6-Pack
First time purchasing Advantage II for large and small cats. It works exactly as it says! Fleas start dying within 2 hours. Normally when I use topical flea treatments, my catā€™s reaction would be squinting of the eyes, and jumping around. I was happy about that. I noticed fleas had fallen off my cats. Iā€™ve never seen this when I used to use frontline Plus. Noticed them more because I had a white cover laid across their bedding and saw more than I needed to! Donā€™t get me wrong. Iā€™ve used the white sheet before when doing flea treatments and have never seen this. I will continue to use Advantage II on all my cats from now on! ... show more
Reviewed in the United States on September 6, 2026 by Sophisticat36
    • 4 months to get rid of fleas so use consistently with shampoos as well.
Size: 2-Pack
Price is much cheaper than in store. However, it take 4 months to get rid of fleas! Inside cats that took a trip to groomer for nail trims both came home with the right flea! Ugh! Never had any fleas before and I was very diligent on using this product. I was hesitant using chemicals but the vet recommended this when not being able to go in. Cats tolerated it. Started July and took till end of November last year. Constant bathing and washing everything in the house including carpets and furniture. Everything, every room the cats went into. Always had inside cats but never fleas! Wouldn't wish them on any pet! This product seemed to work with the persistent scratching for maybe a week and then I would have to wait another month to give them another treatment. Vet did say fleas were really bad last year. ... show more
Reviewed in the United States on September 13, 2026 by R Mosher
    • Good effective flea medication šŸ‘
Size: 2-Pack
Review Image by Elizabeth
Seems to have worked perfectly my cat had little to no reaction to it besides him being confused at to what was on his head and his fleas were dropping off of him 30 mins or so after applying and his flea eggs and flea dirt disappeared and he seems relieved the itching and biting has stopped ima post a photo of him for funny:) ... show more
Reviewed in the United States on September 18, 2026 by Elizabeth
    • READ THIS
Size: 6-Pack
Review Image by KForbess
Review Image by KForbess
Review Image by KForbess
With my review i am going to address points from reviews posted. This review is only based on my personal experiences. 1. Price. Yes, this product is expensive. However, it's absolutely worth it. It works very well and I've always felt that my cats not suffering is more important than the price tag. Also, here on amazon is significantly cheaper than other places. (Saved $20 buying it here instead of 1800petmeds) 2. Balding. There are a few things that need to be known for this product. Make sure you are using the appropriate dose for your cats. Weigh them. Do not assume their weight. If they are on the borderline, use the smaller dose or dont use all of the larger one. Also dont put it all in one spot. Make a line from the back of their neck to their shoulder blades. 3. "Frontline is cheaper and does the same thing". Incorrect! Frontline is cheaper but in order for frontline to work, the fleas have to bite the animals. This product does not require them to be bitten. 4. "Fleas didnt go away." You cannot expect any flea product to completely rid your home of them. It takes a minimum of 3 months to completely get rid of them if you actively fight against the fleas. You need to vacuum your floors and furniture every day at least for awhile. You also need to keep up with your laundry and wash blankets regularly, including your bedding. And its also very important to be spraying your furniture down with flea spray. RAID or Hotshot work wonders for this! Spray your furniture and bedding down every night. I also spray in the crevices of my apartment because fleas like to hide. 5. "Fleas were going everywhere so i had to give them a flea bath." Do NOT do this. Them jumping off your pets is a GOOD thing! That means the product is working. If you bathe them before the product has time to set it, you just wasted your money. This is why you need to be keeping up with prevention in your home. Theyre jumping off your animal because the product is working. Vacuuming, washing, and spraying is what will combat the infestation. You CANNOT get rid of fleas completely in a short period of time so dont expect a miracle. That's where people get disappointed. Let the product do its job and play catch up for the next few months. And make sure you're keeping up with the doses!! ... show more
Reviewed in the United States on June 20, 2017 by KForbess
    • Works immediately
Size: 6-Pack
One drop. Keeps fleas & ticks away away away! I used it on a rescued rabbit with fleas. None remained! No scent or post application scratching, and last a long time, like 3 months for my cat.
Reviewed in the United States on October 11, 2026 by Kimberly C
    • Not Sure if This Worked on its own
Size: 2-Pack
Review Image by Frank Abignail
Not sure if this ointment worked or not. I was able to apply to both my cats' neck but still found fleas after a few days of diligently removing a few every night. It may not be good for outdoor cats as they will tend to keep going back to the Flea source (inside the bushes in our case) but the fleas did eventually go away (I'm just not sure if it was because of me combing the fleas out and bathing them or if this topical ointment worked. I haven't had to reapply in a year so it might have had something to do with the disappearance of the fleas. Iw Ould recommend it since it doesn't hurt the cats and you definitely want to throw everything you got at the bugs to prevent them from reproducing. ... show more
Reviewed in the United States on September 18, 2026 by Frank Abignail

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