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Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 2-Month Supply

  • Based on 74,983 reviews
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Availability: In Stock.
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Arrives Tuesday, Aug 5
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Size: 2-Pack


Style: Large Cat only


Features

  • Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
  • Vet-recommended, easy-to-apply monthly topical treatment no hard-to-swallow pills, no prescription needed
  • Delivers total flea protection kills adult fleas, flea larvae and flea eggs through contact
  • Same-day effectiveness kills fleas within 12 hours of application and keeps working for 30 days
  • Fragrance-free formula, waterproof after 24 hours of application

Description

Advantage II Large Cat is a vet-recommended, leading brand in cat flea protection. Advantage II Large Cat flea treatment and prevention kills adult fleas, flea larvae and flea eggs to deliver total flea protection to your cat or kitten. Within 12 hours of application, Advantage II Large Cat topical treatment gets straight to work killing fleas through contact, so they don’t have to bite your cat to die. This treatment works hard for 30 days following application, effectively breaking the flea life cycle, controlling existing flea infestations and preventing further infestations all month long.Fleas not only cause discomfort; they can also pose other health risks. Monthly use of Advantage II Large Cat is important to protect your cat against fleas that may cause transmission of tapeworms, Flea Allergy Dermatitis and flea bite anemia.That’s why Advantage II Large Cat makes applying treatment simple. This convenient, spot-on application goes on the back of your cat’s neck at the base of the skull. You’ll simply place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. It goes on in seconds! It's easier than a flea collar and there are no hard-to-swallow pills. You’ll also love that Advantage II Large Cat is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects.Advantage II Large Cat flea protection is effective on both indoor and outdoor cats. Your cat should be at least 8 weeks old and weigh over 9 lbs. to use Advantage II Large Cat.For the ultimate convenience in care, Advantage II Large Cat is available over the counter – no prescription needed. And, you can stock up with a subscription for regular doorstep deliveries so you never miss a monthly treatment. Advantage II Large Cat is a trademark of Elanco or its affiliates.

Brand: Advantage


Item Form: Topical


Scent: Unscented


Item Weight: 18.14 g


Active Ingredients: Imidacloprid, Pyriproxyfen


Item Volume: 1.6 Milliliters


Allergen Information: Allergen-Free


Dog Breed Size: Large


Age Range (Description): 8 weeks and older


UPC:


Is Discontinued By Manufacturer ‏ : ‎ No


Product Dimensions ‏ : ‎ 1 x 4.38 x 4.75 inches; 0.64 ounces


Item model number ‏ : ‎ 86336677


Date First Available ‏ : ‎ September 1, 2014


Manufacturer ‏ : ‎ Elanco US Inc


Country of Origin ‏ : ‎ Germany


Best Sellers Rank: #54 in Pet Supplies (See Top 100 in Pet Supplies) #1 in Cat Flea Drops


#1 in Cat Flea Drops:


Customer Reviews: 4.5 4.5 out of 5 stars 74,983 ratings


Item Weight: 0.64 ounces


Manufacturer: Elanco US Inc


Country of Origin: Germany


Item model number: 86336677


Date First Available: September 1, 2014


Item Package Dimensions L x W x H: 10.75 x 4.69 x 1.06 inches


Item Dimensions LxWxH: 1 x 4.38 x 4.75 inches


Item Weight: 18.14 g


Brand Name: Advantage


Target Audience Keyword: house-cats


Directions: Application Instructions 1. Use only on cats. 2. Hold applicator tube in an upright position. Pull cap off tube. 3. Turn the cap around and place other end of cap back on tube. Twist cap to break seal, then remove cap from tube. 4. Part the hair at the base of the cat’s skull until skin is visible. 5. Evenly apply the entire contents of the Advantage II tube directly on the skin by squeezing the entirety of the contents in that one spot. Do not get this product in your cat’s eyes, or allow your cat to ingest this product.


Model Name: Advantage II


Color: Large Cat only


Size: 2-Pack


Age Range Description: 8 weeks and older


Number of Items: 1


Style: Large Cat only


Breed Recommendation: Large


Specific Uses for Product: Parasites


Frequently asked questions

No, the Advantage II is specifically designed for large cats over 9 pounds. For smaller cats or kittens, it's suggested to use a different variation of Advantage.

This package provides a 2-month supply. It's recommended to apply the treatment monthly for continuous flea protection.

Yes, Advantage II for Large Cats is a vet-recommended flea treatment and prevention product.

Advantage II works by killing fleas through contact, meaning they don’t have to bite your cat to die. It kills fleas within 12 hours of the first application and prevents further flea infestations for up to a month.

Top Amazon Reviews

🚀 Abunda's Overview

This is our summary and key points to consider based on customer reviews.


Advantage II Large Cat is a well-reviewed flea treatment for cats over nine pounds. It efficiently kills adult fleas, their larvae, and eggs, causing a significant reduction in flea infestations within days. The formula, which is applied topically, begins working in twelve hours and is effective for thirty days. It is praised for its ease of use, as no prescription is needed, and for its effectiveness, even in comparison to more expensive brands.

Pros

  • 👍 Highly effective in eliminating fleas
  • 🐱 Designed specifically for large cats over nine pounds
  • 🏥 No need for a vet's prescription
  • ⏰ Begins working in 12 hours, provides protection for 30 days
  • 💦 Easy to apply and dries quickly

Cons

  • 👃 Has a slightly "chemical" smell, although it dissipates once dried
  • 💲 May seem a bit expensive, but users agree the effectiveness justifies the cost

Should I Buy It?

Based on the overwhelmingly positive reviews and the effectiveness of the product, even in severe infestations, purchasing Advantage II Large Cat flea treatment appears to be a wise decision. The product works fast, keeps working for a month, and requires no prescription. Despite a slightly chemical smell and a higher price range, it is dramatically effective and often outperforms more expensive brands. If flea treatment for large cats is what you need, this product is highly recommended.


  • REVIEW OF ADVANTAGE II LARGE CAT FLEA CONTROL
Size: 6-Pack Style: Large Cat only
PROS: works well, appropriate for large cats, easy application, ability to buy in bulk CONS: expensive, sometimes applicator breaks, stinky smell! I first purchased this product in August 2015, Again in Janurary 2016, and I just purchased this again (July 2016). I purchased this product to help control fleas on my two cats, one of which is an indoor/outdoor cat. The neighborhood I live in has terrible fleas, so using flea medication is essential. The product arrived quickly, and came with thorough instructions, which I skimmed. The medication comes in a tiny tube incased in a foil packet. I opened the packet, and took out the tube. You break the seal on the tube by inverting the cap and puncturing the seal. I did this and accidentally twisted, causing the point on the top of the lid to become lodged in the opening of the tube. This was stressful because each treatment is so expensive. I realized, however, that I could fish out the point with some tweezers and still use the product! I then pinned my cat down and applied the product to the back of their neck. While I did see a decrease in fleas, I still saw several. I increased application to once every two weeks, and added baths and flea combing to the regime. Eventually, I was able to apply only once a month. During the summer the flea population seems to increase, which also coincided with my adoption of a second cat. I noticed the cat came in with fleas and I applied this medication, but it didn't seem to do much. I then woke up one morning with about 30 flea bites covering my lower legs and feet! I was horrified, and I knew it was time to get serious! After a bit of research I realized apart of why the medication may have been ineffective previously was that I wasn't applying it correctly (ha! Thats what i get for skimming!) Rereading instructions, I realized that I need to part my cats fur and try to make skin contact with the medication. I also learned that if my cats lick it it will taste bitter, discouraging licking behaviors of the medication. I'm going to include a few steps I took to control fleas in my house, unrelated to this product, but I think it might be useful! Scroll down to my conclusion if uninterested :) Anyways, so my cats hate baths (they were both rescued and are older so its hard to introduce new behaviors, I mean, I'm no jackson galaxy) For this reason flea baths always stressed me out and I was worried about my cats catching a cold or licking the flea shampoo and getting sick.Instead of bathing my cats, I gave them a pill that will kill all the fleas on them within 6 hours( https://www.amazon.com/Novartis-Capstar-Flea-Tablets-Count/dp/B005Z6UL1M/ref=sr_1_2?ie=UTF8&qid=1469319334&sr=8-2&keywords=flea+killer+pill). Using this pill in conjunction with this treatment, was a life saver! The next thing I did was give my pets a dry, diatomaceous earth bath. If you choose to do this with your cats, make sure you use food grade DE. DE is a great natural alternative for flea control, but the dust can be damaging to yourself and your cats! To prevent this, I wore a bandana around my mouth, and I stuck a comfy cone on my cat ( https://www.amazon.com/Comfy-Cone-E-Collar-Large-Black/dp/B000XY7CKE/ref=sr_1_1?ie=UTF8&qid=1469319818&sr=8-1&keywords=comfy+cone). My cats didn't like it, but it was safer and easier than flea baths! I also put some apple cider vinegar diluted with water in a spray bottle, and I sprayed down my cats. They hated this, but I think it maybe helped the fleas? It also reduced dust from the DE. CONCLUSION: I think that all cat owners should use this product on their cats, even if their cats are indoor cats. an inch of prevention is worth a pound of solution, and this is especially true for fleas. Make sure to treat your cats regularly and make sure you apply it correctly! included some photos of my happy flea free cats :) ... show more
Reviewed in the United States on July 24, 2016 by Devi Devi

  • Good price for one tube
Size: 1-Pack Style: Large Cat only
It’s a flea and tick remedy, well priced, and it works. I think it may be has a gentler formula, as my cat didn’t react as most do to a foreign substance. She remained calm after I put it on her. A good surprise! good price
Reviewed in the United States on July 2, 2025 by Celestial Cat

  • Flea & Tick Rub in Medicine
Size: 6-Pack Style: Large Cat only
Advantage II large cat flea & tick rub in medicine. Works well with once a month treatment.
Reviewed in the United States on July 19, 2025 by Penny Warner

  • Good value
Size: 6-Pack Style: Large Cat only
Really like the brand and product works as it should.
Reviewed in the United States on July 8, 2025 by A Brown

  • This is the answer to flea control
Size: 4-Pack Style: Large Cat only
Advantage is the best product out there for killing fleas and reducing their reproduction. After trying garlic pills after, flea sprays , horrible, smelling medication’s andhaving a commercial pest control come in ,I lost one dog to flea bites. He totally improved the quality of life for the dogs and eventually there was no fleas at all on a half acre property. So easy to use, once a month, doesn’t smell, doesn’t wash off and really isn’t expensive relative to what I spent on other treatments. ... show more
Reviewed in the United States on July 30, 2025 by Rob Livingstone

  • great flea medicine
Size: 4-Pack Style: Large Cat only
Best flea medicine we have used. with 6 cats we have tried a lot of others. This works great on 5 of 6 cats. on one cat cat it "burns" his skin and the fur falls out leaving a bare spot. All othet 5 cats are good
Reviewed in the United States on July 17, 2025 by scott

  • Excellent product and worth every penny!
Size: 6-Pack Style: Large Cat only
I won't mention names. But, don't waste your time buying cheaper products, especially if your cats actively have fleas. I used a different product for several years. Evidently, my cats became immune to it. I ended up with a full on flea infestation in my home. It was located primarily in my hallway, master bedroom, and my bed. I purchased food grade DE powder. I followed the instructions. It worked well. Unfortunately, I have MCAS and the DE powder caused a severe reaction. I don't recommend that process to anyone. I purchased a different brand of flea & tick medication. I had to dose my 7 cats twice. It did not work completely. I put this flea and tick medicine on my cats two days ago. They come in nice little tubes. It's easy to apply. Each dose is individually packages. No scissors needs to open these large bulky contraptions with very little medication in them. I've deflead my home. This problem is just about resolve now. I highly recommend and will continue purchasing this brand only! Thank you! ... show more
Reviewed in the United States on June 19, 2025 by Sophia David

  • Not helpful in the long run
Size: 2-Pack Style: Large Cat only
Only worked for a week. These fleas are getting hard to get rid of this time around
Reviewed in the United States on July 29, 2025 by Khayla

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