Search  for anything...
Advantage

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 6-Month Supply

  • Based on 80,815 reviews
Condition: New
Checking for the best price...
$69.92 Why this price?

Buy Now, Pay Later

As low as $11.65 / mo
  • – 6-month term
  • – No impact on credit to apply
  • – Instant approval decision
  • – Secure and straightforward checkout

Ready to go? Add this product to your cart and select a plan during checkout.

Payment plans are offered through our trusted finance partners Klarna, Affirm, Afterpay, Zip, Apple Pay, and Google Pay. No-credit-needed leasing options through Acima may also be available at checkout.

Learn more about financing & leasing here.

Selected Option

Free shipping on this product

FREE 30-day refund/replacement

To qualify for a full refund, items must be returned in their original, unused condition. If an item is returned in a used, damaged, or materially different state, you may be granted a partial refund.

To initiate a return, please visit our Returns Center.

View our full returns policy here.

Availability: In Stock.
Fulfilled by Amazon
Arrives Monday, Sep 28
Order within 17 hours and 59 minutes
Available payment plans shown during checkout
Protection Plan Protect Your Purchase
Checking for protection plans...

Recently Viewed

Size: 6-Pack


Features

  • Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
  • Vet-recommended, easy-to-apply monthly topical treatment no hard-to-swallow pills, no prescription needed
  • Delivers total flea protection kills adult fleas, flea larvae and flea eggs through contact
  • Same-day effectiveness kills fleas within 12 hours of application and keeps working for 30 days
  • Fragrance-free formula, waterproof after 24 hours of application

Description

Advantage II Large Cat is a vet-recommended, leading brand in cat flea protection. Advantage II Large Cat flea treatment and prevention kills adult fleas, flea larvae and flea eggs to deliver total flea protection to your cat or kitten. Within 12 hours of application, Advantage II Large Cat topical treatment gets straight to work killing fleas through contact, so they don’t have to bite your cat to die. This treatment works hard for 30 days following application, effectively breaking the flea life cycle, controlling existing flea infestations and preventing further infestations all month long.Fleas not only cause discomfort; they can also pose other health risks. Monthly use of Advantage II Large Cat is important to protect your cat against fleas that may cause transmission of tapeworms, Flea Allergy Dermatitis and flea bite anemia.That’s why Advantage II Large Cat makes applying treatment simple. This convenient, spot-on application goes on the back of your cat’s neck at the base of the skull. You’ll simply place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. It goes on in seconds! It's easier than a flea collar and there are no hard-to-swallow pills. You’ll also love that Advantage II Large Cat is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects.Advantage II Large Cat flea protection is effective on both indoor and outdoor cats. Your cat should be at least 8 weeks old and weigh over 9 lbs. to use Advantage II Large Cat.For the ultimate convenience in care, Advantage II Large Cat is available over the counter – no prescription needed. And, you can stock up with a subscription for regular doorstep deliveries so you never miss a monthly treatment. Advantage II Large Cat is a trademark of Elanco or its affiliates.

Brand: Advantage


Item Form: Topical


Scent: Unscented


Item Weight: 1.76 ounces


Active Ingredients: Imidacloprid 9.10%, Pyriproxyfen 0.46%


Item Volume: 4.8 ml


Allergen Information: Allergen-Free


Dog Breed Size: Large


Unit Count: 6 Count


Color: Large Cat only


Product Dimensions ‏ : ‎ 1.38 x 4.38 x 6.63 inches; 1.76 ounces


Item model number ‏ : ‎ 86336774


Date First Available ‏ : ‎ March 2, 2011


Manufacturer ‏ : ‎ Elanco US Inc


Best Sellers Rank: #67 in Pet Supplies (See Top 100 in Pet Supplies) #1 in Cat Flea Drops


#1 in Cat Flea Drops:


Customer Reviews: 4.5 4.5 out of 5 stars (80,815)


Brand Name: Advantage


Unit Count: 6 Count


Age Range Description: 8 weeks and older


UPC: 724089202321


Global Trade Identification Number: 21


Item Type Name: Topical


Manufacturer: Elanco US Inc


Model Number: 86336774


Manufacturer Part Number: 86336774


Item Form: Topical


Scent Name: Unscented


Dog Breed Size: Large


Target Species: Cat


Item Weight: 1.76 ounces


Volume: 4.8 ml


Allergen Information: Allergen-Free


Active Ingredients: Imidacloprid 9.10%, Pyriproxyfen 0.46%


Frequently asked questions

If you place your order now, the estimated arrival date for this product is: Monday, Sep 28

Yes, absolutely! You may return this product for a full refund within 30 days of receiving it.

To initiate a return, please visit our Returns Center.

View our full returns policy here.

  • Klarna Financing
  • Affirm Pay in 4
  • Affirm Financing
  • Afterpay Financing
  • Zip Pay in 4
  • Financing through Apple Pay
  • Financing through Google Pay
Leasing options through Acima may also be available during checkout.

Learn more about financing & leasing here.

Similar Products

Top Amazon Reviews

    • IT WORKS! 24 hours after application and NO LIVE FLEAS.
Size: 1-Pack
Review Image by Verified Amazon Customer
Review Image by Verified Amazon Customer
Review Image by Verified Amazon Customer
Review Image by Verified Amazon Customer
I like to know things. One question I had was how in the *#*@ does an indoor cat get fleas? I looked it up and it's a lot more common that one might think. Fleas are jumpy little things that find their way onto shoes, clothing, and other things people bring home with them. Unless one never leaves their house, there's a very good chance of bringing fleas in with you without ever knowing. Long story short, once I noticed the fleas, I took steps to get it under control. A flea comb is essential! My vet recommended a topical, so I spent the big money and went with a FRONT of the LINE solution. It was supposed to be the best in the biz. I followed the directions and it did absolutely **nothing** for my cat. I was still combing live fleas out of her by the hundreds. It was a total waste of money. A week later I applied another dose of the FRONT of the LINE topical. Again, it did absolutely **nothing** for her. After which, I tried a flea spray to no advantage. She hated it, it smelled terrible, and because she hated it, I couldn't get it far enough into her long fur for it to do any good. We ended up using the spray on our furniture and her carpets. We did NOT want to put her in the bathtub. I mean, if you've ever bathed a cat in less than a full suit of armor, you know what I'm talking about. I purchased a dry flea & tick shampoo along with the same brand of spray. The waterless flea bath "does" kill fleas after a few seconds in the foam, but she hated it so much her behavior changed drastically. Drastically enough that it scared the crap out of me. She stopped coming in the living room, stopped perching on the back of my chair, wouldn't jump on me for cuddles, was lethargic, and stopped sleeping on my chest after I went to bed. She wasn't acting like herself. At. All. That said, I was still combing live fleas out by the dozens. That number would have been a lot higher but since she was already not acting like herself, I didn't want to stress her out even more by doing more combing. Enter Advantage II Large Cat. I always do a lot of research before using a new product. I had seen the nightmare reviews of skin burns and worse. Even so, there were a lot more good reviews than bad...and I was getting desperate. Using the Advantge II Large Cat was my 2nd to last resort. IF it didn't work, she was going to get a water bath...and I don't have a suit of armor. I was looking as forward to doing that as I would look forward to dragging my body over razor wire...which is essentially the same thing. I am very happy, thrilled in fact, to report that this product worked beautifully! I properly applied the product on 10/29/25 at 3pm. I was very careful to make sure I parted her long fur enough for it to get on her skin. The product takes a full 12 hours to reach is max potency. After 12 hours, I was coming less live fleas from her. It is now 10/31/25 and at last combing, there were NO live fleas. Zero. Ziltch. Nada. Her behavior is returning to normal, she's not scratching/biting like a little banshee anymore, and she had no adverse reactions to the product. I will continue to be diligent with the flea comb to see if she needs another treatment next week. Knowing what I know now, I wish I wouldn't have wasted my money on the FRONT of the LINE solution and used Advantage II Large Cat from the get go. I could have saved my cat and myself a lot of undo stress and worry. I highly recommend this product. Note: If one is worried about their cat's skin, I recommend using one or two drops to "test" how your cat will react to it before giving the full dose. ... show more
Reviewed in the United States on October 31, 2025 by Verified Amazon Customer
    • Fast relief for stressed out cats and tired owners.
Size: 1-Pack
TL;DR: Works quickly, easy to use, and stopped a full flea flare up in a day without turning it into a huge chore. We grabbed this during a sudden little outbreak, and I was honestly relieved at how simple it was to use. The tube opens cleanly without splattering, and the liquid goes right onto the skin without any fighting or trying to part the fur forever. Our big cat barely reacted, which made the whole thing easier. What stood out most, though, was how fast it worked. By the next day, the scratching had almost completely stopped, and the fleas we saw earlier were gone. There’s something comforting about using a product that doesn’t need tricks or follow up treatments right away. It just gets in there, does the job, and lets the whole house calm down again. I also appreciate that it’s unscented. No strong chemical smell lingering on the cat or in the room. As the days went on, the difference stayed steady. No more tiny specks showing up, no more frantic grooming, and the cat settled right back into normal behavior. It didn’t irritate his skin or leave any oily patch that lingered forever, which sometimes happens with other treatments. This one soaked in cleanly and didn’t bother him at all. Having something that clears things up fast is a huge help when you’re juggling pets, kids, and everything else. It feels like a reliable tool you keep on hand just in case, and it’s reassuring knowing you’re using something vet recommended with ingredients that have been around for years. There’s a good sense of trust that comes with that. What I like most is the peace of mind afterward. Once it kicked in, the whole flea situation was just done, and that kind of quick resolution is worth a lot. It’s the kind of product you’re grateful to have on hand before a problem turns into a bigger headache. Tip: Apply it when your cat is relaxed and already settled so the dose goes on smoothly without any twisting or fussing. Don't let them flick their head and splash it in your eyes! Hope this helps! =) ... show more
Reviewed in the United States on December 7, 2025 by Thraddash
    • Works fast and keeps the fleas away!
Size: 4 Pack
I use Advantage II Large Cat (for cats over 9 lbs) on my big boy and it’s been excellent. Within about 12 hours of applying it I started seeing dead fleas, and after a full application the problem was under control. It kills adults, larvae, and eggs, so it actually breaks the cycle instead of just treating what’s visible. Application is easy just part the fur at the base of the neck and apply. No strong smell, and once it’s dry it’s waterproof. He’s over 9 lbs so this size is perfect for him, and I’ve had no irritation or issues. Reliable, vet-recommended, and effective. Highly recommend for large cats if you’re dealing with fleas or want solid monthly prevention! ... show more
Reviewed in the United States on July 25, 2026 by Danielle Christensen
    • Effective Flea Treatment but Requires Careful Use
Size: 1-Pack
This flea treatment works fairly well overall, especially for controlling active flea problems. After applying it, I noticed a reduction in fleas within a day or two, and it continued to help keep them under control for a few weeks. It’s easy to apply, and the single-dose tube makes the process quick without too much hassle. One of the good things about this product is that it targets fleas at different stages, which helps prevent them from coming back too quickly. It’s also convenient for monthly use, especially if you’re trying to stay on top of flea prevention. However, there are a few things to keep in mind. Some cats may be sensitive to topical treatments, so it’s important to monitor your pet after application. There can also be a slight oily residue at the application spot for a short time, which isn’t ideal but does go away. Additionally, while it works well for many cats, the effectiveness can vary depending on how severe the flea problem is or the environment. Overall, it’s a decent and fairly reliable option for flea control when used correctly. It does the job for most situations, but it’s worth keeping an eye on your cat and making sure it’s the right fit for their needs. ... show more
Reviewed in the United States on April 9, 2026 by Simplified
    • READ THIS
Size: 6-Pack
Review Image by KForbess
Review Image by KForbess
Review Image by KForbess
With my review i am going to address points from reviews posted. This review is only based on my personal experiences. 1. Price. Yes, this product is expensive. However, it's absolutely worth it. It works very well and I've always felt that my cats not suffering is more important than the price tag. Also, here on amazon is significantly cheaper than other places. (Saved $20 buying it here instead of 1800petmeds) 2. Balding. There are a few things that need to be known for this product. Make sure you are using the appropriate dose for your cats. Weigh them. Do not assume their weight. If they are on the borderline, use the smaller dose or dont use all of the larger one. Also dont put it all in one spot. Make a line from the back of their neck to their shoulder blades. 3. "Frontline is cheaper and does the same thing". Incorrect! Frontline is cheaper but in order for frontline to work, the fleas have to bite the animals. This product does not require them to be bitten. 4. "Fleas didnt go away." You cannot expect any flea product to completely rid your home of them. It takes a minimum of 3 months to completely get rid of them if you actively fight against the fleas. You need to vacuum your floors and furniture every day at least for awhile. You also need to keep up with your laundry and wash blankets regularly, including your bedding. And its also very important to be spraying your furniture down with flea spray. RAID or Hotshot work wonders for this! Spray your furniture and bedding down every night. I also spray in the crevices of my apartment because fleas like to hide. 5. "Fleas were going everywhere so i had to give them a flea bath." Do NOT do this. Them jumping off your pets is a GOOD thing! That means the product is working. If you bathe them before the product has time to set it, you just wasted your money. This is why you need to be keeping up with prevention in your home. Theyre jumping off your animal because the product is working. Vacuuming, washing, and spraying is what will combat the infestation. You CANNOT get rid of fleas completely in a short period of time so dont expect a miracle. That's where people get disappointed. Let the product do its job and play catch up for the next few months. And make sure you're keeping up with the doses!! ... show more
Reviewed in the United States on June 20, 2017 by KForbess
    • It worked very well for my cats!
Size: 4 Pack
I have two indoor cats that had never had fleas before. After a trip, we noticed they were scratching a lot. I wasn’t sure the first product had completely solved the problem, so I tried Advantage II. I applied it to both cats on the same day. The next day, I found several fleas around the house, especially near their favorite sleeping area. The fleas were large, but they were lying on their sides and barely moving, which showed the product was working. My cats were much more comfortable after the treatment, and the number of fleas quickly started to decrease. I’ll continue vacuuming to help break the flea cycle, but I’m very happy with the results so far. It was easy to apply and seemed to work quickly. I recommend it to anyone dealing with a similar situation, especially since sometimes you don’t see fleas on your pets — you only notice the scratching. ... show more
Reviewed in the United States on July 25, 2026 by juliana braga
    • This WORKS!
Size: 6-Pack
Least expensive anywhere! My cats don’t like this stuff, but they don’t like any stuff and I despise fleas and ticks more than they don’t like it. All pests are gone and my 5 cats didn’t lose any hair or anything. They just looked peeved for about 12 hours!
Reviewed in the United States on July 27, 2026 by Sherri
    • Jury is out on this treatment
Size: 2-Pack
I've bought this twice using it on two different cats. One that goes outdoors regularly and the other that only ventures out for very short periods of time. Both scratch often indicating mites and fleas, though we've NEVER seen a single flea on them or in the house. (Yes, I know that allergies and food can cause scratching too, but this is seasonal coming more when they spend time outdoors.) My rating is based on mixed results. Applying the product is an admitted challenge as both cats fiercely react when the lotion is sensed on their neck. They immediately jerk away making me wonder if it burns or irritates in some way. I'm also concerned that the application may fail to be totally applied to their skin making it less effective. Sometimes I see them stop scratching a couple days after application, sometimes not. I've purchased product based on their weight to ensure proper dosage. Overall, this is nowhere as effective as what the vet prescribed which immediately stopped the scratching and ear mites. I tried this simply because I can buy it without a prescription. The vet requires me to bring in both cats every six months before renewing the prescription and that costs me many hundreds of dollars which seems totally unnecessary and adds to the already high cost of the treatment prescribed. ... show more
Reviewed in the United States on May 23, 2026 by Mark Lubbock

Can't find a product?

Find it on Amazon first, then paste the link below.
Checking for best price...