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Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 6-Month Supply

  • Based on 37,710 reviews
Condition: New
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Availability: In Stock.
Fulfilled by Amazon

Arrives Wednesday, Nov 5
Order within 1 hour and 50 minutes
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Size: 6-Pack


Style: Large Cat only


Features

  • Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
  • Vet-recommended, easy-to-apply monthly topical treatment no hard-to-swallow pills, no prescription needed
  • Delivers total flea protection kills adult fleas, flea larvae and flea eggs through contact
  • Same-day effectiveness kills fleas within 12 hours of application and keeps working for 30 days
  • Fragrance-free formula, waterproof after 24 hours of application

Description

Advantage II Large Cat is a vet-recommended, leading brand in cat flea protection. Advantage II Large Cat flea treatment and prevention kills adult fleas, flea larvae and flea eggs to deliver total flea protection to your cat or kitten. Within 12 hours of application, Advantage II Large Cat topical treatment gets straight to work killing fleas through contact, so they don’t have to bite your cat to die. This treatment works hard for 30 days following application, effectively breaking the flea life cycle, controlling existing flea infestations and preventing further infestations all month long.Fleas not only cause discomfort; they can also pose other health risks. Monthly use of Advantage II Large Cat is important to protect your cat against fleas that may cause transmission of tapeworms, Flea Allergy Dermatitis and flea bite anemia.That’s why Advantage II Large Cat makes applying treatment simple. This convenient, spot-on application goes on the back of your cat’s neck at the base of the skull. You’ll simply place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. It goes on in seconds! It's easier than a flea collar and there are no hard-to-swallow pills. You’ll also love that Advantage II Large Cat is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects.Advantage II Large Cat flea protection is effective on both indoor and outdoor cats. Your cat should be at least 8 weeks old and weigh over 9 lbs. to use Advantage II Large Cat.For the ultimate convenience in care, Advantage II Large Cat is available over the counter – no prescription needed. And, you can stock up with a subscription for regular doorstep deliveries so you never miss a monthly treatment. Advantage II Large Cat is a trademark of Elanco or its affiliates.

Brand: Advantage


Item Form: Topical


Scent: Unscented


Item Weight: 0.8 Ounces


Active Ingredients: Imidacloprid 9.10%, Pyriproxyfen 0.46%


Item Volume: 4.8 Milliliters


Allergen Information: Allergen-Free


Dog Breed Size: Large


Age Range (Description): 8 weeks and older


UPC:


Is Discontinued By Manufacturer ‏ : ‎ No


Product Dimensions ‏ : ‎ 1.38 x 4.38 x 6.63 inches; 0.8 ounces


Manufacturer recommended age ‏ : ‎ 1 month and up


Item model number ‏ : ‎ 86336774


Date First Available ‏ : ‎ March 2, 2011


Manufacturer ‏ : ‎ Elanco US Inc


Best Sellers Rank: #101 in Pet Supplies (See Top 100 in Pet Supplies) #1 in Cat Flea Drops


#1 in Cat Flea Drops:


Customer Reviews: 4.6 4.6 out of 5 stars 37,710 ratings


Item Weight: 0.8 ounces


Manufacturer: Elanco US Inc


Item model number: 86336774


Date First Available: March 2, 2011


Item Package Dimensions L x W x H: 6.69 x 4.33 x 1.38 inches


Item Dimensions LxWxH: 1.38 x 4.38 x 6.63 inches


Item Weight: 0.8 Ounces


Brand Name: Advantage


Target Audience Keyword: house-cats


Directions: Application Instructions 1. Use only on cats. 2. Hold applicator tube in an upright position. Pull cap off tube. 3. Turn the cap around and place other end of cap back on tube. Twist cap to break seal, then remove cap from tube. 4. Part the hair at the base of the cat’s skull until skin is visible. 5. Evenly apply the entire contents of the Advantage II tube directly on the skin by squeezing the entirety of the contents in that one spot. Do not get this product in your cat’s eyes, or allow your cat to ingest this product.


Country of Origin: Germany


Model Name: Advantage II


Color: Large Cat only


Size: 6-Pack


Age Range Description: 8 weeks and older


Care Instructions: Topical


Number of Items: 1


Style: Large Cat only


Breed Recommendation: Large


Specific Uses for Product: Parasites


Frequently asked questions

If you place your order now, the estimated arrival date for this product is: Wednesday, Nov 5

Yes, absolutely! You may return this product for a full refund within 30 days of receiving it.

To initiate a return, please visit our Returns Center.

View our full returns policy here.

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Top Amazon Reviews


  • Worked for my Maine Coon
Size: 6-Pack Style: Large Cat only
This is the 4th product ive tried to treat my girl's fleas with. The other ones, I think it wasnt enough because she is a Maine Coon. Even though she's still a kitten technically, she is larger than most full grown cats already. I also tried a couple shampoos, and while they helped, only barely. I was at my wits end when a friend reccomend I look this one up. Sure enough, morning after application, I check her bedroom sleeping spots, and they are dying and falling off. So, it went to work right away. She is scratching less, and seems more relaxed. She has had no side effects, no salivating or vomiting or anything. Just dead fleas. So, worth the money. This will be my new flea medication to keep my girl happy and healthy and without irritation. ... show more
Reviewed in the United States on August 14, 2025 by Clare

  • Cat saver!
Size: 6-Pack Style: Large Cat only
My cats had fleas BAD, and this killed all the fleas that were on them, and it's been killing them as they get on the cats. I haven't noticed any side effects. There was no strong smell. Product was easy to open, easy to apply, and is working great.
Reviewed in the United States on October 13, 2025 by BatMom6

  • Works fast, great flea protection
Size: 6-Pack Style: Large Cat only
I was skeptical at first if this would work or not since I have four cats and there was a lot. Between bathing, using the flea comb and spraying their room, it was hard to get rid of the infestation. After applying the treatment to all four cats, I started to see improvement within a few days. I used a flea comb to check for any signs of fleas but there wasn’t. ... show more
Reviewed in the United States on October 11, 2025 by Mina Mina

  • Works well but may irritate cat's skin (not severely, if legitimate product)
Size: 6-Pack Style: Large Cat only
I used Advantage and Advantage II on my previous cat for years. Worked great for fleas. The only adverse effect was that it seemed to irritate his skin; no fur loss or sores like some of the other reviews have posted, but he just acted like it stung. He'd run away and hide from me for awhile after each application, and he'd blink his eyes like the fumes bothered him. No serious harm, and it worked great. I had never used Advantage II before on my current cat. I was scared by the reviews that said they either changed the formula or there were counterfeit products out there causing wounds and fur loss. So I called Bayer to check on the batch before using it. The most important thing they told me was to check the two lot numbers on the bottom of the box, and make sure those match the lot numbers stamped on the foil packet surrounding each individual dose. They did match, and the representative told me that the lot I had should be fine. My current cat didn't notice at all when I squirted the stuff on the back of his head. He did throw up a hairball about 10 minutes after the application, but it's not unusual for him to throw up hairballs. Most likely a coincidence, but I will make note of whether it happens again after future applications. Can't be positive whether it's helping fleas, because I wasn't certain whether he had fleas to begin with. I never saw any fleas, but he was itching a lot, and I sometimes found little bumps on myself that may have been flea bites. He does seem to be itching a lot less. I'm still getting bit at night, but these look like bedbug bites (which I thought I had gotten rid of), not fleas. Deducted one star because of how unpleasant it was for my previous cat, and the mildly suspicious hairball ejection from my current cat. Otherwise, great product. ... show more
Reviewed in the United States on August 4, 2018 by Punintended

  • The BEST, period.
Size: 6-Pack Style: Large Cat only
I’ve used this product on my many cats for over 30 years. The best, most efficient topical treatment. On the expensive side but worth it.
Reviewed in the United States on October 12, 2025 by Catherine Sophie Reese

  • Excellent product and worth every penny!
Size: 6-Pack Style: Large Cat only
I won't mention names. But, don't waste your time buying cheaper products, especially if your cats actively have fleas. I used a different product for several years. Evidently, my cats became immune to it. I ended up with a full on flea infestation in my home. It was located primarily in my hallway, master bedroom, and my bed. I purchased food grade DE powder. I followed the instructions. It worked well. Unfortunately, I have MCAS and the DE powder caused a severe reaction. I don't recommend that process to anyone. I purchased a different brand of flea & tick medication. I had to dose my 7 cats twice. It did not work completely. I put this flea and tick medicine on my cats two days ago. They come in nice little tubes. It's easy to apply. Each dose is individually packages. No scissors needs to open these large bulky contraptions with very little medication in them. I've deflead my home. This problem is just about resolve now. I highly recommend and will continue purchasing this brand only! Thank you! ... show more
Reviewed in the United States on June 19, 2025 by Sophia David

  • Works good
Size: 6-Pack Style: Large Cat only
It does the job and kills them pesky fleas. After bout 2 weeks they come back And it kills them again so I like thieproduct so far.
Reviewed in the United States on October 12, 2025 by Kuwlpapa

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