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Advantage

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 6-Month Supply

  • Based on 75,948 reviews
Condition: New
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  • – 6-month term
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Availability: In Stock.
Fulfilled by Amazon
Arrives Saturday, Sep 20
Order within 23 hours and 40 minutes
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Size: 6-Pack


Style: Large Cat only


Features

  • Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
  • Vet-recommended, easy-to-apply monthly topical treatment no hard-to-swallow pills, no prescription needed
  • Delivers total flea protection kills adult fleas, flea larvae and flea eggs through contact
  • Same-day effectiveness kills fleas within 12 hours of application and keeps working for 30 days
  • Fragrance-free formula, waterproof after 24 hours of application

Description

Advantage II Large Cat is a vet-recommended, leading brand in cat flea protection. Advantage II Large Cat flea treatment and prevention kills adult fleas, flea larvae and flea eggs to deliver total flea protection to your cat or kitten. Within 12 hours of application, Advantage II Large Cat topical treatment gets straight to work killing fleas through contact, so they don’t have to bite your cat to die. This treatment works hard for 30 days following application, effectively breaking the flea life cycle, controlling existing flea infestations and preventing further infestations all month long.Fleas not only cause discomfort; they can also pose other health risks. Monthly use of Advantage II Large Cat is important to protect your cat against fleas that may cause transmission of tapeworms, Flea Allergy Dermatitis and flea bite anemia.That’s why Advantage II Large Cat makes applying treatment simple. This convenient, spot-on application goes on the back of your cat’s neck at the base of the skull. You’ll simply place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. It goes on in seconds! It's easier than a flea collar and there are no hard-to-swallow pills. You’ll also love that Advantage II Large Cat is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects.Advantage II Large Cat flea protection is effective on both indoor and outdoor cats. Your cat should be at least 8 weeks old and weigh over 9 lbs. to use Advantage II Large Cat.For the ultimate convenience in care, Advantage II Large Cat is available over the counter – no prescription needed. And, you can stock up with a subscription for regular doorstep deliveries so you never miss a monthly treatment. Advantage II Large Cat is a trademark of Elanco or its affiliates.

Brand: Advantage


Item Form: Topical


Scent: Unscented


Item Weight: 0.8 Ounces


Active Ingredients: Imidacloprid 9.10%, Pyriproxyfen 0.46%


Item Volume: 4.8 Milliliters


Allergen Information: Allergen-Free


Dog Breed Size: Large


Age Range (Description): 8 weeks and older


UPC:


Is Discontinued By Manufacturer ‏ : ‎ No


Product Dimensions ‏ : ‎ 1.38 x 4.38 x 6.63 inches; 0.8 ounces


Manufacturer recommended age ‏ : ‎ 1 month and up


Item model number ‏ : ‎ 86336774


Date First Available ‏ : ‎ March 2, 2011


Manufacturer ‏ : ‎ Elanco US Inc


Best Sellers Rank: #67 in Pet Supplies (See Top 100 in Pet Supplies) #1 in Cat Flea Drops


#1 in Cat Flea Drops:


Customer Reviews: 4.5 4.5 out of 5 stars 75,948 ratings


Item Weight: 0.8 ounces


Manufacturer: Elanco US Inc


Item model number: 86336774


Date First Available: March 2, 2011


Item Package Dimensions L x W x H: 6.61 x 4.33 x 1.46 inches


Item Dimensions LxWxH: 1.38 x 4.38 x 6.63 inches


Item Weight: 0.8 Ounces


Brand Name: Advantage


Target Audience Keyword: house-cats


Directions: Application Instructions 1. Use only on cats. 2. Hold applicator tube in an upright position. Pull cap off tube. 3. Turn the cap around and place other end of cap back on tube. Twist cap to break seal, then remove cap from tube. 4. Part the hair at the base of the cat’s skull until skin is visible. 5. Evenly apply the entire contents of the Advantage II tube directly on the skin by squeezing the entirety of the contents in that one spot. Do not get this product in your cat’s eyes, or allow your cat to ingest this product.


Country of Origin: Germany


Model Name: Advantage II


Color: Large Cat only


Size: 6-Pack


Age Range Description: 8 weeks and older


Care Instructions: Topical


Number of Items: 1


Style: Large Cat only


Breed Recommendation: Large


Specific Uses for Product: Parasites


Frequently asked questions

If you place your order now, the estimated arrival date for this product is: Saturday, Sep 20

Yes, absolutely! You may return this product for a full refund within 30 days of receiving it.

To initiate a return, please visit our Returns Center.

View our full returns policy here.

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Similar Products

Top Amazon Reviews

    • Reliable Flea Protection That Works Quickly
Size: 4-Pack Style: Large Cat only
I’ve been using Advantage II for my large cat (over 12 lbs), and it’s the only flea treatment I fully trust. Within just a day of applying it, I noticed a big difference—scratching stopped, and I wasn’t finding fleas on her bedding anymore. By the second day, the fleas were completely gone. Application is simple: just part the fur at the base of the neck and apply directly to the skin. My cat tolerates it well, and the formula dries quickly without leaving a greasy mess. I also appreciate that it’s waterproof after 24 hours, so I don’t have to worry if she gets into a little rain or needs a bath. The 4-month supply is cost-effective compared to buying single doses, and I like knowing I can stay ahead of any infestations. This product really delivers on prevention as well—no fleas have come back in between monthly doses. If you have a bigger cat and need something safe, effective, and vet-recommended, this is an excellent choice. It gives peace of mind and keeps both your cat and your home flea-free. Highly recommend! ... show more
Reviewed in the United States on August 22, 2025 by tara speece
    • Worked for my Maine Coon
Size: 6-Pack Style: Large Cat only
This is the 4th product ive tried to treat my girl's fleas with. The other ones, I think it wasnt enough because she is a Maine Coon. Even though she's still a kitten technically, she is larger than most full grown cats already. I also tried a couple shampoos, and while they helped, only barely. I was at my wits end when a friend reccomend I look this one up. Sure enough, morning after application, I check her bedroom sleeping spots, and they are dying and falling off. So, it went to work right away. She is scratching less, and seems more relaxed. She has had no side effects, no salivating or vomiting or anything. Just dead fleas. So, worth the money. This will be my new flea medication to keep my girl happy and healthy and without irritation. ... show more
Reviewed in the United States on August 14, 2025 by Clare
    • Efectivo.
Size: 1-Pack Style: Large Cat only
t's a very good product. My kitten had fleas and it worked very well. It didn't irritate or cause allergies, and the fleas went away. I recommend it.
Reviewed in the United States on September 2, 2025 by Andy
    • San Diego fleas are developing immunity
Size: 1-Pack Style: Large Cat only
I've used Advantage on my cats for 20 years. It worked perfectly until this year. I live on the coast in San Diego. Several veterinarians have told me that the fleas in this area have developed a high tolerance to it, making it a bit less effective than before. As a result I've had to switch to prescription flea meds. I've not heard of this being a problem in other places throughout the U.S. it's worth asking people in your area, to find out what works the best. ... show more
Reviewed in the United States on August 7, 2025 by Flametop Guitars
    • Fast acting and long lasting.
Size: 6-Pack Style: Large Cat only
Tried several other name brands. This one dose the trick. Last about 40 days before needed again. Save you pets from the torture of the flea bites works within 2 days. Pets are happy no more scratching! Would recommend this to anyone.
Reviewed in the United States on August 19, 2025 by Douglas K
    • Excellent product and worth every penny!
Size: 6-Pack Style: Large Cat only
I won't mention names. But, don't waste your time buying cheaper products, especially if your cats actively have fleas. I used a different product for several years. Evidently, my cats became immune to it. I ended up with a full on flea infestation in my home. It was located primarily in my hallway, master bedroom, and my bed. I purchased food grade DE powder. I followed the instructions. It worked well. Unfortunately, I have MCAS and the DE powder caused a severe reaction. I don't recommend that process to anyone. I purchased a different brand of flea & tick medication. I had to dose my 7 cats twice. It did not work completely. I put this flea and tick medicine on my cats two days ago. They come in nice little tubes. It's easy to apply. Each dose is individually packages. No scissors needs to open these large bulky contraptions with very little medication in them. I've deflead my home. This problem is just about resolve now. I highly recommend and will continue purchasing this brand only! Thank you! ... show more
Reviewed in the United States on June 19, 2025 by Sophia David
    • No More Itchy Business—Our Streetwise Cat Is Now Pest-Free and Fancy
Size: 4-Pack Style: Large Cat only
Review Image by Lacy Jane Lacy Jane
This monthly flea treatment deserves a standing ovation (or at least a slow blink of approval from our formerly feral feline). After adopting us post-cat fight and claiming our porch as his kingdom, he brought along a few unwanted guests—tiny, jumpy, itchy ones. We needed something effective, fast, and drama-free. This stuff? Total win. Application was a breeze—no wrestling match, no betrayal stares. Just a quick squeeze between the shoulder blades and voilà: flea eviction notice served. Within days, he was lounging like a spa guest, not a flea motel. Now he’s neutered, healed, and living his best life—still flea-free, still fabulous. If your cat has a flair for the dramatic or a past life as a street brawler, this treatment is the peace treaty you’ve been waiting for. ... show more
Reviewed in the United States on August 19, 2025 by Lacy Jane Lacy Jane

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