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Advantage

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 6-Month Supply

  • Based on 78,657 reviews
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  • – 6-month term
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Availability: In Stock.
Fulfilled by Amazon
Arrives Thursday, Aug 13
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Size: 6-Pack


Features

  • Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
  • Vet-recommended, easy-to-apply monthly topical treatment no hard-to-swallow pills, no prescription needed
  • Delivers total flea protection kills adult fleas, flea larvae and flea eggs through contact
  • Same-day effectiveness kills fleas within 12 hours of application and keeps working for 30 days
  • Fragrance-free formula, waterproof after 24 hours of application

Description

Advantage II Large Cat is a vet-recommended, leading brand in cat flea protection. Advantage II Large Cat flea treatment and prevention kills adult fleas, flea larvae and flea eggs to deliver total flea protection to your cat or kitten. Within 12 hours of application, Advantage II Large Cat topical treatment gets straight to work killing fleas through contact, so they don’t have to bite your cat to die. This treatment works hard for 30 days following application, effectively breaking the flea life cycle, controlling existing flea infestations and preventing further infestations all month long.Fleas not only cause discomfort; they can also pose other health risks. Monthly use of Advantage II Large Cat is important to protect your cat against fleas that may cause transmission of tapeworms, Flea Allergy Dermatitis and flea bite anemia.That’s why Advantage II Large Cat makes applying treatment simple. This convenient, spot-on application goes on the back of your cat’s neck at the base of the skull. You’ll simply place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. It goes on in seconds! It's easier than a flea collar and there are no hard-to-swallow pills. You’ll also love that Advantage II Large Cat is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects.Advantage II Large Cat flea protection is effective on both indoor and outdoor cats. Your cat should be at least 8 weeks old and weigh over 9 lbs. to use Advantage II Large Cat.For the ultimate convenience in care, Advantage II Large Cat is available over the counter – no prescription needed. And, you can stock up with a subscription for regular doorstep deliveries so you never miss a monthly treatment. Advantage II Large Cat is a trademark of Elanco or its affiliates.

Brand: Advantage


Item Form: Topical


Scent: Unscented


Item Weight: 0.11 Pounds


Active Ingredients: Imidacloprid 9.10%, Pyriproxyfen 0.46%


Item Volume: 4.8 Milliliters


Allergen Information: Allergen-Free


Dog Breed Size: Large


Unit Count: 6 Count


Age Range (Description): 8 weeks and older


Is Discontinued By Manufacturer ‏ : ‎ No


Product Dimensions ‏ : ‎ 1.38 x 4.38 x 6.63 inches; 1.76 ounces


Item model number ‏ : ‎ 86336774


Date First Available ‏ : ‎ March 2, 2011


Manufacturer ‏ : ‎ Elanco US Inc


Best Sellers Rank: #51 in Pet Supplies (See Top 100 in Pet Supplies) #1 in Cat Flea Drops


#1 in Cat Flea Drops:


Customer Reviews: 4.5 4.5 out of 5 stars (78,657)


Brand Name: Advantage


Age Range Description: 8 weeks and older


UPC: 724089202321


Global Trade Identification Number: 21


Manufacturer Part Number: 86336774


Model Number: 86336774


Unit Count: 6 Count


Manufacturer: Elanco US Inc


Item Type Name: Topical


Item Form: Topical


Scent Name: Unscented


Dog Breed Size: Large


Target Species: Cat


Item Weight: 0.11 Pounds


Volume: 4.8 Milliliters


Allergen Information: Allergen-Free


Active Ingredients: Imidacloprid 9.10%, Pyriproxyfen 0.46%


Frequently asked questions

If you place your order now, the estimated arrival date for this product is: Thursday, Aug 13

Yes, absolutely! You may return this product for a full refund within 30 days of receiving it.

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View our full returns policy here.

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Similar Products

Top Amazon Reviews

    • IT WORKS! 24 hours after application and NO LIVE FLEAS. IT WORKS! 24 hours after application and NO LIVE FLEAS.
Size: 1-Pack
Review Image by Verified Amazon Customer
Review Image by Verified Amazon Customer
Review Image by Verified Amazon Customer
Review Image by Verified Amazon Customer
I like to know things. One question I had was how in the *#*@ does an indoor cat get fleas? I looked it up and it's a lot more common that one might think. Fleas are jumpy little things that find their way onto shoes, clothing, and other things people bring home with them. Unless one never leaves their house, there's a very good chance of bringing fleas in with you without ever knowing. Long story short, once I noticed the fleas, I took steps to get it under control. A flea comb is essential! My vet recommended a topical, so I spent the big money and went with a FRONT of the LINE solution. It was supposed to be the best in the biz. I followed the directions and it did absolutely **nothing** for my cat. I was still combing live fleas out of her by the hundreds. It was a total waste of money. A week later I applied another dose of the FRONT of the LINE topical. Again, it did absolutely **nothing** for her. After which, I tried a flea spray to no advantage. She hated it, it smelled terrible, and because she hated it, I couldn't get it far enough into her long fur for it to do any good. We ended up using the spray on our furniture and her carpets. We did NOT want to put her in the bathtub. I mean, if you've ever bathed a cat in less than a full suit of armor, you know what I'm talking about. I purchased a dry flea & tick shampoo along with the same brand of spray. The waterless flea bath "does" kill fleas after a few seconds in the foam, but she hated it so much her behavior changed drastically. Drastically enough that it scared the crap out of me. She stopped coming in the living room, stopped perching on the back of my chair, wouldn't jump on me for cuddles, was lethargic, and stopped sleeping on my chest after I went to bed. She wasn't acting like herself. At. All. That said, I was still combing live fleas out by the dozens. That number would have been a lot higher but since she was already not acting like herself, I didn't want to stress her out even more by doing more combing. Enter Advantage II Large Cat. I always do a lot of research before using a new product. I had seen the nightmare reviews of skin burns and worse. Even so, there were a lot more good reviews than bad...and I was getting desperate. Using the Advantge II Large Cat was my 2nd to last resort. IF it didn't work, she was going to get a water bath...and I don't have a suit of armor. I was looking as forward to doing that as I would look forward to dragging my body over razor wire...which is essentially the same thing. I am very happy, thrilled in fact, to report that this product worked beautifully! I properly applied the product on 10/29/25 at 3pm. I was very careful to make sure I parted her long fur enough for it to get on her skin. The product takes a full 12 hours to reach is max potency. After 12 hours, I was coming less live fleas from her. It is now 10/31/25 and at last combing, there were NO live fleas. Zero. Ziltch. Nada. Her behavior is returning to normal, she's not scratching/biting like a little banshee anymore, and she had no adverse reactions to the product. I will continue to be diligent with the flea comb to see if she needs another treatment next week. Knowing what I know now, I wish I wouldn't have wasted my money on the FRONT of the LINE solution and used Advantage II Large Cat from the get go. I could have saved my cat and myself a lot of undo stress and worry. I highly recommend this product. Note: If one is worried about their cat's skin, I recommend using one or two drops to "test" how your cat will react to it before giving the full dose. ... show more
Reviewed in the United States on October 31, 2025 Reviewed in the United States on October 31, 2025 by Verified Amazon Customer
    • Buy it! It works phenomenally per my 4 cats!!
Size: 1-Pack
I can’t believe I used to take my cats to the vet and pay so much $$ when I could have been using this the whole time! It works phenomenally. I have four cats, and when we had an outbreak of fleas, I started researching affordable options not a vet. There were so many good reviews about Advantage II and I was desperate. I ordered the four pack. It worked absolutely wonderfully! Highly recommend this versus spending tons of money at the Vet! Also, when a friend had an outbreak of fleas, I ordered one pack for her to be delivered same day. I got it within two hours of my order! That to me is worth every penny! Thank you Amazon you really came through on this one! ... show more
Reviewed in the United States on June 29, 2026 by S&D
    • Fast relief for stressed out cats and tired owners.
Size: 1-Pack
TL;DR: Works quickly, easy to use, and stopped a full flea flare up in a day without turning it into a huge chore. We grabbed this during a sudden little outbreak, and I was honestly relieved at how simple it was to use. The tube opens cleanly without splattering, and the liquid goes right onto the skin without any fighting or trying to part the fur forever. Our big cat barely reacted, which made the whole thing easier. What stood out most, though, was how fast it worked. By the next day, the scratching had almost completely stopped, and the fleas we saw earlier were gone. There’s something comforting about using a product that doesn’t need tricks or follow up treatments right away. It just gets in there, does the job, and lets the whole house calm down again. I also appreciate that it’s unscented. No strong chemical smell lingering on the cat or in the room. As the days went on, the difference stayed steady. No more tiny specks showing up, no more frantic grooming, and the cat settled right back into normal behavior. It didn’t irritate his skin or leave any oily patch that lingered forever, which sometimes happens with other treatments. This one soaked in cleanly and didn’t bother him at all. Having something that clears things up fast is a huge help when you’re juggling pets, kids, and everything else. It feels like a reliable tool you keep on hand just in case, and it’s reassuring knowing you’re using something vet recommended with ingredients that have been around for years. There’s a good sense of trust that comes with that. What I like most is the peace of mind afterward. Once it kicked in, the whole flea situation was just done, and that kind of quick resolution is worth a lot. It’s the kind of product you’re grateful to have on hand before a problem turns into a bigger headache. Tip: Apply it when your cat is relaxed and already settled so the dose goes on smoothly without any twisting or fussing. Don't let them flick their head and splash it in your eyes! Hope this helps! =) ... show more
Reviewed in the United States on December 7, 2025 by Thraddash
    • Effective Flea Treatment but Requires Careful Use
Size: 1-Pack
This flea treatment works fairly well overall, especially for controlling active flea problems. After applying it, I noticed a reduction in fleas within a day or two, and it continued to help keep them under control for a few weeks. It’s easy to apply, and the single-dose tube makes the process quick without too much hassle. One of the good things about this product is that it targets fleas at different stages, which helps prevent them from coming back too quickly. It’s also convenient for monthly use, especially if you’re trying to stay on top of flea prevention. However, there are a few things to keep in mind. Some cats may be sensitive to topical treatments, so it’s important to monitor your pet after application. There can also be a slight oily residue at the application spot for a short time, which isn’t ideal but does go away. Additionally, while it works well for many cats, the effectiveness can vary depending on how severe the flea problem is or the environment. Overall, it’s a decent and fairly reliable option for flea control when used correctly. It does the job for most situations, but it’s worth keeping an eye on your cat and making sure it’s the right fit for their needs. ... show more
Reviewed in the United States on April 9, 2026 by Simplified
    • REVIEW OF ADVANTAGE II LARGE CAT FLEA CONTROL REVIEW OF ADVANTAGE II LARGE CAT FLEA CONTROL
Size: 6-Pack
Review Image by Devi
Review Image by Devi
Review Image by Devi
Review Image by Devi
PROS: works well, appropriate for large cats, easy application, ability to buy in bulk CONS: expensive, sometimes applicator breaks, stinky smell! I first purchased this product in August 2015, Again in Janurary 2016, and I just purchased this again (July 2016). I purchased this product to help control fleas on my two cats, one of which is an indoor/outdoor cat. The neighborhood I live in has terrible fleas, so using flea medication is essential. The product arrived quickly, and came with thorough instructions, which I skimmed. The medication comes in a tiny tube incased in a foil packet. I opened the packet, and took out the tube. You break the seal on the tube by inverting the cap and puncturing the seal. I did this and accidentally twisted, causing the point on the top of the lid to become lodged in the opening of the tube. This was stressful because each treatment is so expensive. I realized, however, that I could fish out the point with some tweezers and still use the product! I then pinned my cat down and applied the product to the back of their neck. While I did see a decrease in fleas, I still saw several. I increased application to once every two weeks, and added baths and flea combing to the regime. Eventually, I was able to apply only once a month. During the summer the flea population seems to increase, which also coincided with my adoption of a second cat. I noticed the cat came in with fleas and I applied this medication, but it didn't seem to do much. I then woke up one morning with about 30 flea bites covering my lower legs and feet! I was horrified, and I knew it was time to get serious! After a bit of research I realized apart of why the medication may have been ineffective previously was that I wasn't applying it correctly (ha! Thats what i get for skimming!) Rereading instructions, I realized that I need to part my cats fur and try to make skin contact with the medication. I also learned that if my cats lick it it will taste bitter, discouraging licking behaviors of the medication. I'm going to include a few steps I took to control fleas in my house, unrelated to this product, but I think it might be useful! Scroll down to my conclusion if uninterested :) Anyways, so my cats hate baths (they were both rescued and are older so its hard to introduce new behaviors, I mean, I'm no jackson galaxy) For this reason flea baths always stressed me out and I was worried about my cats catching a cold or licking the flea shampoo and getting sick.Instead of bathing my cats, I gave them a pill that will kill all the fleas on them within 6 hours( https://www.amazon.com/Novartis-Capstar-Flea-Tablets-Count/dp/B005Z6UL1M/ref=sr_1_2?ie=UTF8&qid=1469319334&sr=8-2&keywords=flea+killer+pill). Using this pill in conjunction with this treatment, was a life saver! The next thing I did was give my pets a dry, diatomaceous earth bath. If you choose to do this with your cats, make sure you use food grade DE. DE is a great natural alternative for flea control, but the dust can be damaging to yourself and your cats! To prevent this, I wore a bandana around my mouth, and I stuck a comfy cone on my cat ( https://www.amazon.com/Comfy-Cone-E-Collar-Large-Black/dp/B000XY7CKE/ref=sr_1_1?ie=UTF8&qid=1469319818&sr=8-1&keywords=comfy+cone). My cats didn't like it, but it was safer and easier than flea baths! I also put some apple cider vinegar diluted with water in a spray bottle, and I sprayed down my cats. They hated this, but I think it maybe helped the fleas? It also reduced dust from the DE. CONCLUSION: I think that all cat owners should use this product on their cats, even if their cats are indoor cats. an inch of prevention is worth a pound of solution, and this is especially true for fleas. Make sure to treat your cats regularly and make sure you apply it correctly! included some photos of my happy flea free cats :) ... show more
Reviewed in the United States on July 24, 2016 Reviewed in the United States on July 24, 2016 by Devi
    • Works well for my cats
Size: 4-Pack
My cats have benefited from Advantage II over the years. I remember Advantage used to be precription only; I'm not sure if this is a milder OTC version. We don't always have the luxury of prescription flea treatments. I usually give my cats a bath first and wait until they are dry and then put this on the back of their neck. This version of Advantage is affordable enough for me. In the Summer, I really need to give them Bath+Advantage once a month where I live. Grooming and trimming a long hair first, then Bath, then Advantage worked best for my long hair big boy cat. ... show more
Reviewed in the United States on June 27, 2026 by Helper Cat
    • Great flea medicine
Size: 4-Pack
This flea medicine was great for both my cats. I don’t usually use this type of medicine, but it kept them from scratching , worked quickly. The value was great, cheaper than anywhere else I could find it , easy to apply. Definitely will buy it again if my cats need it.
Reviewed in the United States on May 26, 2026 by Pam Borra
    • Doesn't work
Size: 6-Pack
Didn't work for my cats
Reviewed in the United States on June 12, 2026 by Joan

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