$69.92
Buy Now, Pay Later
As low as
$11.65
/ mo
Learn more
- – 6-month term
- – No impact on credit to apply
- – Instant approval decision
- – Secure and straightforward checkout
Ready to go? Add this product to your cart and select a plan during checkout.
Payment plans are offered through our trusted finance partners Klarna, Affirm, Afterpay, Zip, Apple Pay, and Google Pay. No-credit-needed leasing options through Acima may also be available at checkout.
Learn more about financing & leasing here.
Selected Option
Free shipping on this product
Extended holiday returns
FREE refund/replacement until Jan 31, 2027 Learn more
FREE refund/replacement until Jan 31, 2027 Learn more
This item's return window has been extended for the holiday season: FREE refund/replacement until Jan 31, 2027
To qualify for a full refund, items must be returned in their original, unused condition. If an item is returned in a used, damaged, or materially different state, you may be granted a partial refund.
To initiate a return, please visit our Returns Center.
View our full returns policy here.
Availability:
In Stock.
Arrives
Saturday, Nov 14
Recently Viewed
At a glance
- Condition
- New
- Size
- 6-Pack
- Dimensions
- 1.38 x 4.38 x 6.63 in; 1.76 oz
- Weight
- 1.76 oz
- Color
- Large Cat only
- Item Form
- Drops
- Scent
- Unscented
Features 5
- MONTHLY CAT FLEA TREATMENT: This vet-recommended* flea topical for cats treats and prevents flea infestations on cats for one month *Elanco Animal Health. Data on file. REF-23987
- BREAKS THE FLEA LIFECYCLE: This flea topical for cats provides 3-way protection against adult fleas, flea larvae, and flea eggs, effectively breaking the flea lifecycle
- FOR CATS OVER 9 POUNDS: Advantage Large II Cat can be used on cats 8 weeks of age and older, weighing over 9 lbs; also available for kittens 2-5 lbs. and small cats 5-9 lbs.
- FAST-ACTING FLEA TOPICAL: This monthly flea topical for cats kills fleas on cats within 12 hours of application, and it kills reinfesting any fleas within 2 hours
- WORKS THROUGH CONTACT: Advantage II Cat kills fleas through contact, so they don't have to bite your cat to die
Description
Advantage II Large Cat is a vet-recommended, leading brand in cat flea protection. Advantage II Large Cat flea treatment and prevention kills adult fleas, flea larvae and flea eggs to deliver total flea protection to your cat or kitten. Within 12 hours of application, Advantage II Large Cat topical treatment gets straight to work killing fleas through contact, so they don’t have to bite your cat to die. This treatment works hard for 30 days following application, effectively breaking the flea life cycle, controlling existing flea infestations and preventing further infestations all month long.Fleas not only cause discomfort; they can also pose other health risks. Monthly use of Advantage II Large Cat is important to protect your cat against fleas that may cause transmission of tapeworms, Flea Allergy Dermatitis and flea bite anemia.That’s why Advantage II Large Cat makes applying treatment simple. This convenient, spot-on application goes on the back of your cat’s neck at the base of the skull. You’ll simply place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. It goes on in seconds! It's easier than a flea collar and there are no hard-to-swallow pills. You’ll also love that Advantage II Large Cat is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects.Advantage II Large Cat flea protection is effective on both indoor and outdoor cats. Your cat should be at least 8 weeks old and weigh over 9 lbs. to use Advantage II Large Cat.For the ultimate convenience in care, Advantage II Large Cat is available over the counter – no prescription needed. And, you can stock up with a subscription for regular doorstep deliveries so you never miss a monthly treatment. Advantage II Large Cat is a trademark of Elanco or its affiliates.
Specs 23
| Brand | Advantage |
|---|---|
| Item Form | Drops |
| Scent | Unscented |
| Item Weight | 1.76 ounces |
| Active Ingredients | Imidacloprid: 9.10%, Pyriproxyfen: 0.46% |
| Item Volume | 4.8 ml |
| Allergen Information | Allergen-Free |
| Dog Breed Size | Large |
| Unit Count | 6 Count |
| Color | Large Cat only |
| Product Dimensions | 1.38 x 4.38 x 6.63 inches; 1.76 ounces |
| Item model number | 86336774 |
| Manufacturer | Elanco US Inc |
| Brand Name | Advantage |
| Age Range Description | 8 weeks and older |
| UPC | 724089202321 |
| Global Trade Identification Number | 21 |
| Item Type Name | Topical |
| Model Number | 86336774 |
| Manufacturer Part Number | 86336774 |
| Scent Name | Unscented |
| Target Species | Cat |
| Volume | 4.8 ml |
No specs match.
Frequently asked questions
If you place your order now, the estimated arrival date for this product is:
Saturday, Nov 14
Yes, absolutely! This item's return window has been extended for the holiday season: FREE refund/replacement until Jan 31, 2027.
To initiate a return, please visit our Returns Center.
View our full returns policy here.
To initiate a return, please visit our Returns Center.
View our full returns policy here.
- Klarna Financing
- Affirm Pay in 4
- Affirm Financing
- Afterpay Financing
- Zip Pay in 4
- Financing through Apple Pay
- Financing through Google Pay
Learn more about financing & leasing here.
Similar Products
$9/mo*
PetArmor Plus Flea & Tick Topical Dogs 5-22 lbs, 6-Month
$9/mo*
Advantage II Small Cat Topical Flea Treatment & Prevention, 4ct
$9/mo*
PetArmor Plus Flea & Tick Topical Dogs 45-88 lbs, 6-Month
Top Amazon Reviews
Fast relief for stressed out cats and tired owners.
Size: 1-Pack
TL;DR: Works quickly, easy to use, and stopped a full flea flare up in a day without turning it into a huge chore. We grabbed this during a sudden little outbreak, and I was honestly relieved at how simple it was to use. The tube opens cleanly without splattering, and the liquid goes right onto the skin without any fighting or trying to part the fur forever. Our big cat barely reacted, which made the whole thing easier. What stood out most, though, was how fast it worked. By the next day, the scratching had almost completely stopped, and the fleas we saw earlier were gone. There’s something comforting about using a product that doesn’t need tricks or follow up treatments right away. It just gets in there, does the job, and lets the whole house calm down again. I also appreciate that it’s unscented. No strong chemical smell lingering on the cat or in the room. As the days went on, the difference stayed steady. No more tiny specks showing up, no more frantic grooming, and the cat settled right back into normal behavior. It didn’t irritate his skin or leave any oily patch that lingered forever, which sometimes happens with other treatments. This one soaked in cleanly and didn’t bother him at all. Having something that clears things up fast is a huge help when you’re juggling pets, kids, and everything else. It feels like a reliable tool you keep on hand just in case, and it’s reassuring knowing you’re using something vet recommended with ingredients that have been around for years. There’s a good sense of trust that comes with that. What I like most is the peace of mind afterward. Once it kicked in, the whole flea situation was just done, and that kind of quick resolution is worth a lot. It’s the kind of product you’re grateful to have on hand before a problem turns into a bigger headache. Tip: Apply it when your cat is relaxed and already settled so the dose goes on smoothly without any twisting or fussing. Don't let them flick their head and splash it in your eyes! Hope this helps! =)
...
show more
Reviewed in the United States on December 7, 2025 by Thraddash
IT WORKS! 24 hours after application and NO LIVE FLEAS.
Size: 1-Pack
I like to know things. One question I had was how in the *#*@ does an indoor cat get fleas? I looked it up and it's a lot more common that one might think. Fleas are jumpy little things that find their way onto shoes, clothing, and other things people bring home with them. Unless one never leaves their house, there's a very good chance of bringing fleas in with you without ever knowing. Long story short, once I noticed the fleas, I took steps to get it under control. A flea comb is essential! My vet recommended a topical, so I spent the big money and went with a FRONT of the LINE solution. It was supposed to be the best in the biz. I followed the directions and it did absolutely **nothing** for my cat. I was still combing live fleas out of her by the hundreds. It was a total waste of money. A week later I applied another dose of the FRONT of the LINE topical. Again, it did absolutely **nothing** for her. After which, I tried a flea spray to no advantage. She hated it, it smelled terrible, and because she hated it, I couldn't get it far enough into her long fur for it to do any good. We ended up using the spray on our furniture and her carpets. We did NOT want to put her in the bathtub. I mean, if you've ever bathed a cat in less than a full suit of armor, you know what I'm talking about. I purchased a dry flea & tick shampoo along with the same brand of spray. The waterless flea bath "does" kill fleas after a few seconds in the foam, but she hated it so much her behavior changed drastically. Drastically enough that it scared the crap out of me. She stopped coming in the living room, stopped perching on the back of my chair, wouldn't jump on me for cuddles, was lethargic, and stopped sleeping on my chest after I went to bed. She wasn't acting like herself. At. All. That said, I was still combing live fleas out by the dozens. That number would have been a lot higher but since she was already not acting like herself, I didn't want to stress her out even more by doing more combing. Enter Advantage II Large Cat. I always do a lot of research before using a new product. I had seen the nightmare reviews of skin burns and worse. Even so, there were a lot more good reviews than bad...and I was getting desperate. Using the Advantge II Large Cat was my 2nd to last resort. IF it didn't work, she was going to get a water bath...and I don't have a suit of armor. I was looking as forward to doing that as I would look forward to dragging my body over razor wire...which is essentially the same thing. I am very happy, thrilled in fact, to report that this product worked beautifully! I properly applied the product on 10/29/25 at 3pm. I was very careful to make sure I parted her long fur enough for it to get on her skin. The product takes a full 12 hours to reach is max potency. After 12 hours, I was coming less live fleas from her. It is now 10/31/25 and at last combing, there were NO live fleas. Zero. Ziltch. Nada. Her behavior is returning to normal, she's not scratching/biting like a little banshee anymore, and she had no adverse reactions to the product. I will continue to be diligent with the flea comb to see if she needs another treatment next week. Knowing what I know now, I wish I wouldn't have wasted my money on the FRONT of the LINE solution and used Advantage II Large Cat from the get go. I could have saved my cat and myself a lot of undo stress and worry. I highly recommend this product. Note: If one is worried about their cat's skin, I recommend using one or two drops to "test" how your cat will react to it before giving the full dose.
...
show more
Reviewed in the United States on October 31, 2025 by Verified Amazon Customer
72 hours later, we are flea free!
Size: 2-Pack
My particular boy hates all oral meds and rather than fight to the death, I decided to try this based on the ratings. Parted his hair while he was snoozing, applied the treatment on his skin between his shoulders and neck, and let it do its thing. I did a thorough flea comb before applying to try and get out as many as possible, I combed him every day for the last 3 days and today we’re pulling nothing and no flea dust is visible! I’ve not noticed any side effects whatsoever, and he’s just as happy as ever. I did also treat the house with clear spray to prevent a bounce back.
...
show more
Reviewed in the United States on October 16, 2026 by Mercy
4 months to get rid of fleas so use consistently with shampoos as well.
Size: 2-Pack
Price is much cheaper than in store. However, it take 4 months to get rid of fleas! Inside cats that took a trip to groomer for nail trims both came home with the right flea! Ugh! Never had any fleas before and I was very diligent on using this product. I was hesitant using chemicals but the vet recommended this when not being able to go in. Cats tolerated it. Started July and took till end of November last year. Constant bathing and washing everything in the house including carpets and furniture. Everything, every room the cats went into. Always had inside cats but never fleas! Wouldn't wish them on any pet! This product seemed to work with the persistent scratching for maybe a week and then I would have to wait another month to give them another treatment. Vet did say fleas were really bad last year.
...
show more
Reviewed in the United States on September 13, 2026 by R Mosher
Good effective flea medication 👍
Size: 2-Pack
Seems to have worked perfectly my cat had little to no reaction to it besides him being confused at to what was on his head and his fleas were dropping off of him 30 mins or so after applying and his flea eggs and flea dirt disappeared and he seems relieved the itching and biting has stopped ima post a photo of him for funny:)
...
show more
Reviewed in the United States on September 18, 2026 by Elizabeth
READ THIS
Size: 6-Pack
With my review i am going to address points from reviews posted. This review is only based on my personal experiences. 1. Price. Yes, this product is expensive. However, it's absolutely worth it. It works very well and I've always felt that my cats not suffering is more important than the price tag. Also, here on amazon is significantly cheaper than other places. (Saved $20 buying it here instead of 1800petmeds) 2. Balding. There are a few things that need to be known for this product. Make sure you are using the appropriate dose for your cats. Weigh them. Do not assume their weight. If they are on the borderline, use the smaller dose or dont use all of the larger one. Also dont put it all in one spot. Make a line from the back of their neck to their shoulder blades. 3. "Frontline is cheaper and does the same thing". Incorrect! Frontline is cheaper but in order for frontline to work, the fleas have to bite the animals. This product does not require them to be bitten. 4. "Fleas didnt go away." You cannot expect any flea product to completely rid your home of them. It takes a minimum of 3 months to completely get rid of them if you actively fight against the fleas. You need to vacuum your floors and furniture every day at least for awhile. You also need to keep up with your laundry and wash blankets regularly, including your bedding. And its also very important to be spraying your furniture down with flea spray. RAID or Hotshot work wonders for this! Spray your furniture and bedding down every night. I also spray in the crevices of my apartment because fleas like to hide. 5. "Fleas were going everywhere so i had to give them a flea bath." Do NOT do this. Them jumping off your pets is a GOOD thing! That means the product is working. If you bathe them before the product has time to set it, you just wasted your money. This is why you need to be keeping up with prevention in your home. Theyre jumping off your animal because the product is working. Vacuuming, washing, and spraying is what will combat the infestation. You CANNOT get rid of fleas completely in a short period of time so dont expect a miracle. That's where people get disappointed. Let the product do its job and play catch up for the next few months. And make sure you're keeping up with the doses!!
...
show more
Reviewed in the United States on June 20, 2017 by KForbess
A must buy!
Size: 6-Pack
First time purchasing Advantage II for large and small cats. It works exactly as it says! Fleas start dying within 2 hours. Normally when I use topical flea treatments, my cat’s reaction would be squinting of the eyes, and jumping around. I was happy about that. I noticed fleas had fallen off my cats. I’ve never seen this when I used to use frontline Plus. Noticed them more because I had a white cover laid across their bedding and saw more than I needed to! Don’t get me wrong. I’ve used the white sheet before when doing flea treatments and have never seen this. I will continue to use Advantage II on all my cats from now on!
...
show more
Reviewed in the United States on September 6, 2026 by Sophisticat36
Not Sure if This Worked on its own
Size: 2-Pack
Not sure if this ointment worked or not. I was able to apply to both my cats' neck but still found fleas after a few days of diligently removing a few every night. It may not be good for outdoor cats as they will tend to keep going back to the Flea source (inside the bushes in our case) but the fleas did eventually go away (I'm just not sure if it was because of me combing the fleas out and bathing them or if this topical ointment worked. I haven't had to reapply in a year so it might have had something to do with the disappearance of the fleas. Iw Ould recommend it since it doesn't hurt the cats and you definitely want to throw everything you got at the bugs to prevent them from reproducing.
...
show more
Reviewed in the United States on September 18, 2026 by Frank Abignail