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Advantage

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 8-Month Supply

  • Based on 74,769 reviews
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Size: 8-Pack


Style: Large Cat only


Features

  • Contains one 6-pack of Advantage II for Large Cats over 9 lbs and one 2-pack of Advantage II for Large Cats over 9 lbs
  • Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
  • Vet-recommended, easy-to-apply monthly topical treatment no hard-to-swallow pills, no prescription needed
  • Delivers total flea protection kills adult fleas, flea larvae and flea eggs through contact
  • Same-day effectiveness kills fleas within 12 hours of application and keeps working for 30 days
  • Fragrance-free formula, waterproof after 24 hours of application

Description

Advantage II Large Cat is a vet-recommended, leading brand in cat flea protection. Advantage II Large Cat flea treatment and prevention kills adult fleas, flea larvae and flea eggs to deliver total flea protection to your cat or kitten. Within 12 hours of application, Advantage II Large Cat topical treatment gets straight to work killing fleas through contact, so they don’t have to bite your cat to die. This treatment works hard for 30 days following application, effectively breaking the flea life cycle, controlling existing flea infestations and preventing further infestations all month long. This convenient, spot-on application goes on the back of your cat’s neck at the base of the skull. It goes on in seconds! You’ll also love that Advantage II Large Cat is fragrance-free and waterproof after 24 hours of application. Advantage II Large Cat flea protection is effective on both indoor and outdoor cats. Advantage II Large Cat is a trademark of Elanco or its affiliates.

Brand: Advantage


Item Form: Topical


Scent: Unscented


Active Ingredients: imidacloprid


Dog Breed Size: Large


Age Range (Description): Kittens


Date First Available ‏ : ‎ October 6, 2022


Manufacturer ‏ : ‎ Advantage


Best Sellers Rank: #59 in Pet Supplies (See Top 100 in Pet Supplies) #1 in Cat Flea Drops


#1 in Cat Flea Drops:


Customer Reviews: 4.5 4.5 out of 5 stars 74,769 ratings


Manufacturer: Advantage


Date First Available: October 6, 2022


Brand Name: Advantage


Color: Large Cat only


Size: 8-Pack


Age Range Description: Kittens


Style: Large Cat only


Breed Recommendation: Large Breeds


Frequently asked questions

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Top Amazon Reviews

    • Advantage II Large Cat Flea Treatment: Effective and Hassle-Free Protection!
Size: 4-Pack Style: Large Cat only
The Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention (4-Month Supply, Cats Over 9 lbs.) has been a game-changer for my indoor-outdoor cat. This topical solution, backed by veterinarians, is super easy to apply—just a quick squeeze at the base of the skull, no pills required. The fragrance-free formula kills fleas, larvae, and eggs on contact within 12 hours, preventing bites and breaking the flea life cycle for a full 30 days per dose. My cat’s scratching stopped almost immediately, and I’ve noticed no fleas since starting the treatment. The 4-month supply is convenient and cost-effective, with no prescription needed, and the waterproof formula holds up after 24 hours, perfect for my cat who loves exploring. The active ingredients, imidacloprid and pyriproxyfen, work effectively without needing fleas to bite, reducing risks like tapeworm or dermatitis. Application is straightforward, though I ensure my cat doesn’t lick the spot initially to avoid mild salivation. While some users report rare skin irritation, my cat had no issues, but I’d suggest monitoring after the first use and consulting a vet for sensitive pets. For anyone with a cat over 9 lbs. needing reliable flea control, this is a solid, vet-trusted choice that delivers peace of mind and a happy, itch-free pet! Consult a veterinarian before use. ... show more
Reviewed in the United States on May 30, 2025 by Martin E.
    • Effective and safe
Size: 4-Pack Style: Large Cat only
Reliable control of fleas for your cat(s). Might be old school product, but gets the job done. Have 2 cats (lighter weight cats) and ordering the product for large (higher weight) cats was able to save $$ by splitting a tube between cats. Ease of application and effective flea control. Put product on my cat as directed between shoulder blades and saw results quickly within hours of application. ... show more
Reviewed in the United States on June 5, 2025 by Amazon Customer
    • Flea free kitty!
Size: 1-Pack Style: Large Cat only
Review Image by Future Investments Future Investments
Our kitty enjoys a flea free lifestyle after we apply this medication. We have been using this for several years and it seems to work better than other brands we have tried in the past. Within 24 hours, there is no more scratching. Now she has time to enjoy the more important things in life.
Reviewed in the United States on May 27, 2025 by Future Investments Future Investments
    • Works pretty good but doesn’t last a full month
Size: 6-Pack Style: Large Cat only
This works well enough if you don’t have active fleas in your yard or house but I usually have to reapply after three weeks during the warmer seasons. I use it for my cats because it’s one of the milder preventables and none of them have any problems tolerating it. It takes several hours to dry and a couple of my cats get a little bit of flakiness where I applied it that is temporary. It starts working fairly fast, within a few hours usually. One warning though, make sure you follow the directions of how and where to put it on so your cat doesn’t have access to lick it off. ... show more
Reviewed in the United States on June 5, 2025 by Janice
    • Got rid of the fleas!
Size: 1-Pack Style: Large Cat only
Used this for my cat and worked great! Got rid of the fleas and mites in under a week. The scratching stopped. I was ver nervous buying from amazon but would definitely recommend.
Reviewed in the United States on June 2, 2025 by Kiana
    • Great protection for cats
Size: 6-Pack Style: Large Cat only
I have been using this for years on my girls and it is very effective. Plus I got it on sale which was even more awesome.
Reviewed in the United States on May 27, 2025 by Amazon Customer
    • Won't use anything else
Size: 6-Pack Style: Large Cat only
Been using this for year on both cats. I have a big cat (25 lbs) and a l regular size (12lbs). One season I forgot to get this and within a month they started to get fleas. Put this product on and haven't had a issue since. Easy to apply and easy application .
Reviewed in the United States on May 17, 2025 by J. Donald
    • Unsatisfied
Size: 6-Pack Style: Large Cat only
Well, I'm unsatisfied overall. I have been using this flea and tick medicine for 4 months now and I have been pulling ticks off my cat. And just to be super specific i just reapplied meds to him a week ago and pulled two ticks off him today. Now, I have to say it's only around his eyes or crawling on his fur but I constantly have to check him. Unfortunately, for the price I was hoping for better results. Moving forward with another bread. ... show more
Reviewed in the United States on May 21, 2025 by Alayna

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