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THORNE - PharmaGABA-250 - GABA Supplement - 250 mg Natural Source Gamma-Aminobutyric Acid - Promotes a Calm, Relaxed, Focused State of Mind* - 60 Capsules

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Arrives Saturday, Mar 21
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Features

  • Natural Source: GABA is an important brain chemical that acts like a brake during times of runaway stress*
  • Calm: Promotes a calm, relaxed, focused state of mind*
  • Sleep: Supports restful sleep*
  • 3rd Party Contents Certified: This product has been third-party tested and certified to verify what's in the package matches what's on the label
  • Trusted: Thorne is chosen by champions and trusted by 100+ professional sports teams, a proud partner of U.S. National Teams, and the #1 recommended clinical brand by health-care practitioners (2023 Health-Care Practitioner Seller Survey)

Features

  • Natural Source: GABA is an important brain chemical that acts like a brake during times of runaway stress*
  • Calm: Promotes a calm, relaxed, focused state of mind*
  • Sleep: Supports restful sleep*
  • Clinical Research: Natural-source GABA outperforms synthetic GABA in clinical studies
  • Free From: Every Thorne product is made with the purest possible ingredients - without gluten or other major allergens (eggs, tree nuts, peanuts). This product also contains no soy, dairy, yeast, shellfish, or fish.

Description

PharmaGABA features a natural source of the inhibitory neurotransmitter – GABA. GABA supports restful sleep, acts like a “brake” on stress, and provides a focused state of mind. Well-Researched Benefits Clinical studies show the natural form of GABA in Thorne's PharmaGABA decreases the brain's stress-related beta waves and increases the production of its alpha-waves, creating a sense of physical relaxation while maintaining mental focus. Other studies show reduced pupil diameter, heart rate, and two natural biomarkers of stress – salivary cortisol and chromogranin A – all signs of relaxation. Clinically Studied In a recent study of the effect of GABA supplementation on muscle mass, 21 males, average age 39, who did not exercise regularly, were given 10 grams of whey protein or 10 grams of whey protein plus 100 mg of PharmaGABA daily for 12 weeks. Both groups participated in twice weekly 60-minute strength training sessions that consisted of leg presses, leg extensions, leg curls, chest presses, and pull-downs. Statistically significant increases in total body lean muscle mass was observed in the whey protein-plus-PharmaGABA group but not in the whey-only group. Purest Ingredients The natural GABA in Thorne's PharmaGABA suite is produced via a fermentation process that utilizes Lactobacillus hilgardii, the same bacteria strain used to ferment cabbage in the preparation of the traditional Korean dish, kimchi. Convenient Protocol PharmaGABA-250 offers 250 mg of natural GABA per capsule and is non-habit forming. Read more Read more Sleep isn’t just about “getting a good night’s rest.” New information regularly emerges about sleep’s importance to disease prevention, cognitive function, mood, athletic performance, and even maintaining a healthy weight. The adverse health conditions that can occur with chronically poor sleep include diabetes, obesity, infertility, heart disease, sleep apnea, and more. Unfortunately, even though we might be eating right, exercising, and making healthy decisions, we might be neglecting our sleep. In fact, more than 40 percent of U.S. adults don’t get the ideal amount of sleep each night. One great strategy to get a good night’s sleep is to supplement with nutrients that support sleep’s natural triggers and reduce stress in the body. Thorne offers supplements that support healthy sleep. Read more When the highest standards have been met, Thorne creates higher ones. Sourcing Exceptional Ingredients We develop better standards for higher quality ingredients. Thorne cares deeply about where our ingredients come from. We partner only with suppliers whose practices emphasize quality, science, and responsibility. Better ingredients means better potency, absorption, and digestibility - and ultimately better health. Manufacturing the Right Way We manufacture our own products to ensure full supply chain transparency. For more than 30 years, we have invested in clean manufacturing practices. We refuse to use ingredients that can inhibit absorption. We perform our final production in the United States. Our Charleston, SC facility is third-party certified. Four Rounds of Testing We run four rounds of testing for each of our products. We have invested in two state-of-the-art in-house laboratories that allow us to conduct four rounds of testing, while most competitors test only one or two times. We test our raw materials, in-process batches, finish products, and product stability for each product. Thinking Sustainably We're thinking sustainably to protect our environment. We believe the environment should never be compromised for the sake of business gain. At Thorne, we believe that doing our part to protect the environment and its most valuable resources goes hand in hand with our product quality standards. Read more


Is Discontinued By Manufacturer ‏ : ‎ No


Product Dimensions ‏ : ‎ 2.09 x 2.09 x 3.72 inches; 0.63 Ounces


Date First Available ‏ : ‎ January 1, 2011


Manufacturer ‏ : ‎ Thorne Research


Brand: THORNE


Flavor: natural


Primary Supplement Type: natural GABA


Unit Count: 60 Count


Item Form: Capsule


Item Weight: 2.4 ounces


Item dimensions L x W x H: 2.09 x 2.09 x 3.72 inches


Product Benefits: Sleep Support


Age Range (Description): Adult


Package Information: Bottle


Is Discontinued By Manufacturer ‏ : ‎ No


Product Dimensions ‏ : ‎ 2.09 x 2.09 x 3.72 inches; 2.4 ounces


Item model number ‏ : ‎ SP662-R


Date First Available ‏ : ‎ January 1, 2011


Manufacturer ‏ : ‎ Thorne Research


Best Sellers Rank: #20,705 in Health & Household (See Top 100 in Health & Household) #630 in Blended Vitamin & Mineral Supplements #1,914 in Diet & Sports Nutrition


#630 in Blended Vitamin & Mineral Supplements:


#1,914 in Diet & Sports Nutrition:


Customer Reviews: 4.6 4.6 out of 5 stars (638)


Frequently asked questions

If you place your order now, the estimated arrival date for this product is: Saturday, Mar 21

This item is non-returnable:

Non-returnable due to Food safety reasons

View our full returns policy here.

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Top Amazon Reviews


  • Found something that finally works
My physician recommended this for my anxiety. I had tried many other supplements on my own that all promised to calm, relax, help focus, help sleep, etc. I have struggled with insomnia, anxiety and panic attacks for the past 4 years. I am currently taking Xanax to help manage my symptoms but I do not want to stay on Xanax the rest of my life. This is the only product that I have found that actually works. It keeps the anxiety from getting out of control. I can usually just breathe through it now. And this supplement has allowed me to start dosing back on Xanax. I take PharmaGaba 3 times daily as recommended. It does not make me sleepy but rather just levels everything out. It does not feel like I took a Xanax which you definitely feel the affects of but rather I noticed that I just felt calm throughout the day. No ups and downs, no jitters, no racing heart, no fight or flight feeling. It really has given me hope that I will be able to get off of Xanax and start to manage my anxiety in a healthier way. ... show more
Reviewed in the United States on June 14, 2022 by yogachic

  • Good product
Product as described
Reviewed in the United States on January 2, 2026 by Melissa keith

  • great for upside down cortisol levels + need to sleep at night
I did a sleep/stress test and learned that my cortisol was upside down. Low in the morning - so sluggish and can't get out of bed, even at 10 AM, I could only get up because I HAD TO. High in the evening - laying in bed, almost like I have a panic attack - so alert, I can't sleep. I'm taking a few supplements now and altering my diet and lifestyle to reduce my cortisol levels. I want them high in the morning, so I can spring out of bed and low in the evening to lay down and rest. This PharmaGABA-250 is one of the supplements I started taking with the guidance of a functional nutritionist after we saw my cortisol labs. I can report that I noticed the effect of this supplement. I took it with a small glass of water about 30 minutes before bedtime. Fifteen minutes in, I started to feel very heavy - like how I feel when I'm sleepy. I did my bedtime routine - put on PJs, washed my face, brushed my teeth, etc., and got into bed. I woke up the next day a few minutes BEFORE my alarm. I felt refreshed, perfect. I've been taking this every night and have had great success, except one night when I had some sugar close to bedtime (I had cocoa), that disrupted the experience. So, GABA helps a lot, but diet also impacts me. One dose-related caution I would use is that my partner wanted to try this supplement to help him sleep when stressed about work. He couldn't stop thinking about work. He took one pill (same as I do), and he slept. He felt very heavy the next day and struggled with work in the morning, which was the exact opposite effect he wanted. He might benefit from Thorne's lower (100mg) dose. We've ordered it, but he hasn't tried it yet. If you're not sure how much you need, I recommend starting with the lower dose because you can always take more of them if you find you need them. ... show more
Reviewed in the United States on July 13, 2022 by McJeeee

  • Migraine miracle
I have many, many food sensitivities that trigger migraines. Many of these foods are high glutamate foods. My dr. told me to try this because the gabba counteracts the glutamate somehow. I do t remember what he said, but it made sense at the time. Anyway, does gabba get rid of my migraines? No. Does it make it so that I can take some caffeinated Tylenol and not be praying for death because of the pain? Yes! In fact, I can usually get rid of the pain altogether. The exhaustion and aphasia will just be what they will be, but at least the pain is manageable. This is a godsend for me. ... show more
Reviewed in the United States on July 19, 2022 by Elaine

  • Stress reducer
This helps with brain firing it relaxes you but not in the sleepy sense. I usually take one to two before I go to bed or two in the morning before I start my day. It makes me feel less stressed.
Reviewed in the United States on November 12, 2024 by Designer Girl

  • Excellent quality product that works for me!
This is my first time purchasing this dosage; pricey but cheaper than taking 2 at the lower dose. First of all, I use muscle testing to figure out what I need, how much and what brand would be best for me. Out of lots of options on Amazon, this brand has consistently tested as the best option and I have used them for various things for a couple of years. So I definitely trust their quality. I can’t compare them in any other way or give evidence, only consistent experience and what I have seen with muscle testing. The interesting part of that is that I have gone into health food stores before and muscle tested options and nothing has tested strong. And I had to look at Amazon to find something. That says a lot to me. Plus Amazon usually tends to have better prices generally than health food stores. With Prime and considering gas and time, Amazon is usually the better option if it isn’t an emergency. I have been using this for stress and anxiety issues and take it in the morning. I know others who take it at night to help with sleep. It has definitely helped. My daughter has also been taking it and feels like it really makes a difference for her as well. I also have recommended this to friends. Wish I had known about it sooner! ... show more
Reviewed in the United States on September 20, 2019 by Shannon

  • Great product
This product really helps us sleep without being draggy in the morning
Reviewed in the United States on October 21, 2025 by Hatch

  • If this doesn't work, then GABA isn't what you need
My research shows me that this is a high quality product. And I don't base that on widely varying reviews. If GABA is actually what you need, then this supplement should help. If it is not what your particular situation requires, it will probably do nothing and you could then end your GABA supplementation experiment. My experience is that taking 250mg on an empty stomach in the morning gives me an uneasy feeling in about 10 minutes and subsides in about 20. I cut back to 100mg and don't get that feeling. I don't take it later in the day, as GABA can increase your mental focus and keep you awake. I was on Xanax VERY INFREQUENTLY in the past and GABA supplementation has replaced that medication for me. You may also consider a HIGH QUALITY vitamin B supplement in your supplementation experiments. I recommend this product based only on my personal experience. Your physiology may give you a totally different experience. ... show more
Reviewed in the United States on March 14, 2022 by E. F. K.

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