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Nature's Trove

Nature's Trove SAM-e 400mg 90 Enteric Coated Caplets. Vegan, Kosher, Non-GMO Project Verified, Soy Free, Gluten Free - Cold Form Blister Packed.

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Availability: In Stock.
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Arrives Friday, Nov 28
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Size: 90 Count (Pack of 1)


Features

  • PREMIUM QUALITY: Nature's Trove is committed to making the highest quality SAM-e supplements affordable for all consumers. We start with raw material that contains the highest level of the active S.S. Isomer, and manufacture it under strictly controlled GMP conditions. The caplets are enteric coated for optimal absorption, and blister packaged for maximum freshness. Our product is free from allergens, artificial coloring and flavors; suitable for vegan, GMO free, and Kosher certified.
  • EXPERTISE & INDUSTRY LEADERSHIP: Our experts have been working with SAM-e (s-adenosylmethionine) and perfecting its formulation for over 2 decades. We are pleased to present a product that is backed by an incredible amount of science, literature, and research studies.
  • Joint Health & Well-Being: SAM-e may help maintain joint health & well-being.

Description

What is SAMe? SAM-e (S-Adenosyl-Methionine) is a revolutionary dietary supplement that has been successfully used for nearly half a century to support joint health and well-being. SAM-e is an amino acid that is naturally produced by the body; however, aging, diet, and other factors may cause the levels of SAM-e in one’s body to decline. Nature’s Trove SAM-e is here to help replenish and support beneficial levels of SAM-e in the body. Why choose Nature’s Trove SAMe? The Nature’s Trove team of experts has been working with SAMe for over two decades, and are pioneers in the field. Nature’s Trove SAM-e is a stable, bioavailable form of S-Adenosyl-Methionine, and contains the highest levels of S,S Isomer (active component) available on the market. It is specially manufactured and packaged to maintain optimum potency. The caplets are enteric coated to ensure that they are optimally absorbed by the body for maximum benefit. We are confident that you will enjoy Nature’s Trove SAM-e. As with all Nature’s Trove products, we take great pride in bringing you nature’s greatest treasures at their highest quality. At Nature’s Trove, we believe that natural health should be accessible to all, and by offering our products directly to you, we are achieving this goal, one customer at a time. Recommended dosage: As a dietary supplement, take one caplet daily, preferably on an empty stomach, or as directed by a physician. For some people, additional supplementation may be beneficial. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand: Nature's Trove


Flavor: Unflavored


Unit Count: 90 Count


Item Form: Caplets


Item Weight: 5.57 ounces


Product Benefits: Bone & Joint Support,Brain Health Support


Age Range (Description): Adult


Package Information: Blister


Number of Items: 1


Servings per Container: 90


Is Discontinued By Manufacturer ‏ : ‎ No


Package Dimensions ‏ : ‎ 5.39 x 3.2 x 3 inches; 5.57 ounces


Item model number ‏ : ‎ TRSAM490


Date First Available ‏ : ‎ April 13, 2017


Manufacturer ‏ : ‎ Nature's Trove


Best Sellers Rank: #2,701 in Health & Household (See Top 100 in Health & Household) #30 in Blended Vitamin & Mineral Supplements


#30 in Blended Vitamin & Mineral Supplements:


Customer Reviews: 4.5 4.5 out of 5 stars 13,212 ratings


Frequently asked questions

If you place your order now, the estimated arrival date for this product is: Friday, Nov 28

This item is non-returnable:

Non-returnable due to Food safety reasons

View our full returns policy here.

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Top Amazon Reviews

    • Works for me!
Size: 30 Count (Pack of 1)
This is a great product that works well for me. My moods are stabilized and joint pain is lessened.
Reviewed in the United States on September 10, 2025 by Fran O.
    • Effective and Affordable
Size: 60 Count (Pack of 2)
I’ve been taking Sam-e for roughly 25 years and switched to this brand maybe 5 years ago when the NatureMade brand became too expensive. This brand works very well, not only to combat depression, especially during the winter months, but it also eliminates my knee pain when running. Because it was unavailable for a while, I tried another “all in one” brand that was supposedly the same strength as these and within about 8 weeks both my knee pain and depression returned. Thankfully, the Natures Trove brand became available again. Problem solved! I’d say it takes a week or two to start working with full benefits within a month. The price is significantly lower than other brands. ... show more
Reviewed in the United States on July 23, 2025 by FindPrimal
    • Fast and good source of nutritional supplements.
Size: 60 Count (Pack of 2)
SAMe, S-adenyl L Methionine has been noted by research to improve cartilage formation. As you see from the name, it is essentially an amino acid. I purchased the 200 and 400 mg quantities. The product is a molecule that is synthesized by some yeasts - bakers' yeast is most common. While I cannot personally double-blind test its effectiveness, scientific evaluation has, and has shown it to increase cartilage recovery. I nearly completely re-tore a long-previously reconstructed knee , and, as my other knee had also been damaged by significant aerial mistakes and landings I sought more than just the usual chondroitin, MSM, etc. Having seen live images of the cartilage damage in my knees, and exploring the research, I strongly feel that SAMe is worth purchase. This brand is naturally-sourced - a good selling point, and it is reasonably priced on comparison to many others. SAMe is also sold as neuroactive, due to its part in the synthesis of serotonin, which was a matter of concern. Serotonin is synthesized through the production and synthesis of this molecule, in great part by mutualist symbiotic enteric microorganisms. Again, because this is natural, it is almost certainly a good nutritional supplement, as enteric organisms tend to change quickly in response to different dietary intake. Thus, it promotes more regular synthesis of one of the most important neurotransmitters. Due to the highly stressful period in which all of us are immersed, I haven't looked deeper into that neurological issue, although we DO know a few things about it. Serotonin itself cannot cross into the brain, and that produced in the intestines affects other physiological processes - we need it. But excess serotonin production in the brain affects males and females differently and the brain's feedback processes tend to act to restore normality (it's possible that some individuals may experience persistent insufficiency OR excess, but those are a small minority. .If you suspect such long-term problem, do consult a medical therapist - Psychologists can refer those with metabolic problems of persistent types to psychiatrists who can test for such problems. But recognize that serotonin understanding is in its infancy, and the past with its SSRIs and other quite invasive drugging, is like using a hammer to fix a computer board or a brain) That, in short, is why I do NOT recommend that people seek neurotropic drugs - from alcohol to other drugs, we interfere with or destroy natural functioning, which it's sometimes better to address ONLY through physical, mental, social activities. SAMe is, though, pretty much methionine, a food, and we may often be deficient in that amino acid - which is why it can improve cartilage formation, as well as other variables like digestion. So, explore the effects of ANYTHING you ingest, and DO NOT just take things because of inane claims unsupported by rigorous scientific research. This company was extremely responsive (FAST!) to my Amazon order, and, so, with its component sourcing, seems a great place from which to purchase nutritional products. While I have experienced reduced pain , I had also been expanding the exercise of joints I injured and reinjured, and so cannot honestly evaluate sensations like pain reduction for others. I use less aspirin since the combination of SAMe, the natural healing process, and slow increase of exercise of affected joints, and as usual recommend any safe reduction of NSAID use. SAMe does not have the deleterious side effects of NSAIDs. ... show more
Reviewed in the United States on July 15, 2020 by Michael M
    • Good quality- helped with mood
Size: 90 Count (Pack of 1)
I just ordered my second box. I like that these are in individual blister packs. They are on the larger side but have no bad taste. I do think they have improved mood but not so sure about sleep quality, focus, or energy level. I like them enough to continue to take them though. This brand was one of the more reputable ones I found. ... show more
Reviewed in the United States on April 10, 2025 by Kathy
    • Better mood and no knee pain at the best price.
Size: 60 Count (Pack of 1)
These are the best priced SAM-e of this quality, hermetically sealed, that I was able to find. SAM-e helps with mood , as we age our bodies produce less and less of this compound. For me personally, the largest reason I take it is knee pain, without SAM-e, I have to take other tablets, so this is a one stop shop for better mood and no knee pain and its a natural compound our bodies make in any case. ... show more
Reviewed in the United States on August 25, 2025 by dbguru
    • Good Paxil supplement!
Size: 60 Count (Pack of 1)
This is a regular ingredient of my daily pill dose. I started taking one tablet a day when 2000 IU of vitamin D3 was insufficient to supplement my proscribed dose of 60mg Paxil. That has now been more than a decade. I grew tired of shopping for drugstore sales and keeping track of paper coupons.
Reviewed in the United States on September 9, 2025 by Fflincher
    • Can't live without them ... highly recommend.
Size: 90 Count (Pack of 1)
I used to be really depressed. I'm not just being flip ... I've been seeing a psychiatrist for about a decade, more off than on in the past two years. I was super depressed. I decided to NOT take anti-depression meds because I wanted to be sure what I was feeling was authentic and because I had tried them in the past unsuccessfully. Through a lot of hard work and patience from my family, friends and doctor, I don't have a diagnosis of depression anymore. I'm a very happy person now! Having said all that LOL ... I still suffer from Seasonal Affective Disorder (SAD) in the winter. I live in a very cloudy city and used to live in a very sunny city. A couple three years ago, I was mentioning this to an older woman and she said "I can help but you have to hear me out." Of course, I was intrigued. She told me about SAMe. I asked her how she found out and she said "A shaman told me." Okay. This person is the LEAST likely person to go see a shaman for anything anywhere but she had run into one on a vacation and he told her to try it. She figured what did she have to lose? Your blues, that's what. So, I got a pack of SAMe, not this brand, kept it in my car and took one every day on my way to work. One day, out of no where, I was like hey, I feel good. GOOD!! I continue to take them until summer rolled around. Once the days start getting shorter, I start taking them again. Since then, they have gone up in price substantially all over. And then you also run the risk of not getting the dosage you need or getting something that upsets your stomach or whatever. So far, I haven't had any trouble with this brand. I feel good. I feel mentally even-keeled, it does seem to help my ever-present joint pain and I just feel BETTER overall when I take SAMe. I have recommended it to many friends and will continue to do so. I was worried about this brand because I read so many people got upset stomachs. I've been fine and my stomach gets upset if I take OTC pain relievers. These are not the magic pill. You can't just take one and everything will be okay. For some people I've talked to, it takes a month or two. For me, it took about a month to really feel the effects the first time. Once I got on my seasonal rotation, it seems to take less time to even out from the SAD effects. The instructions on this pack suggest one a day but say some people might find another one a day beneficial. This is inline with what other brands suggest. I've never had to take more than one a day. There is a warning not to take these if you are bi-polar or maniac depressive or if you are taking prescription anti-depressants. This is something you should talk to your doctor about. There are some side effects, you can find them by doing a web search, but they are rare. YMMV of course. The price on these is VERY reasonable. This is a three-month supply. Unless you have to up the dosage for the first month or two ... It's one thing to give five stars to a sweater or some a kitchen gadget or something but when it comes to something that goes in your body, I think it's important to know if other people have had success. I have had success with this product. I'm going to look to see if I can put it on subscribe and save. It sits by my computer and I take one every morning with my coffee. Sometimes I eat right away, other days I don't. No tummy issues :) ... show more
Reviewed in the United States on May 1, 2020 by TXEggplant

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