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Ortho

Ortho Home Defense Insect Killer for Indoor and Perimeter Refill2 - Ready-To-Use Bug Spray Refill, Kills Ants, Roaches, and Spiders, 1 gal.

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Availability: In Stock.
Fulfilled by Amazon
Arrives Thursday, May 28
Order within 20 hours and 38 minutes
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Size: 1-Pack


Style: Refill


Features

  • INDOOR INSECT KILLER: Ortho Home Defense Insect Killer for Indoor & Perimeter2 is a pest control spray that kills the toughest home-invading insects, including ants, cockroaches, spiders, fleas, ticks, scorpions, earwigs, and more as listed
  • LONG-LASTING PROTECTION: This bug spray for homes creates an indoor bug barrier that provides up to 12 month protection against ants, roaches and spiders when applied indoors on non-porous surfaces
  • WHEN TO USE: Apply this outdoor and indoor bug spray bug killer anytime as a preventative treatment, or after you see evidence of insect activity
  • WHERE TO USE: Use this insect spray indoors in kitchens and bathrooms or around doors and windows, and outdoors to the perimeter of foundations, patios, decks, garages or wherever insects are a recurring problem
  • CONVENIENT OUTDOOR & INDOOR PEST CONTROL REFILL: This 1 gal. Ortho Home Defense Insect Killer for Indoor & Perimeter Refill2 allows you to reuse your Comfort Wand from its original container

Description

Ortho Home Defense Insect Killer for Indoor & Perimeter Refill2 kills common household bugs such as ants, beetles, centipedes, cockroaches, crickets, fleas, flies, millipedes, mosquitoes, moths, spiders, stink bugs, ticks, termites, periodical cicadas and more (as listed). This bug killer spray creates a bug barrier for up to 12 months of barrier protection against ants, roaches and spiders indoors on non-porous surfaces. Plus, the Invisi-Shield Technology formula gives off no fumes, dries clear and dries fast. DIY homeowners can use this outdoor and indoor pest control spray product anytime as a preventative treatment or after you see evidence of insect activity for long lasting-control. Apply indoors in kitchens and bathrooms or around doors and windows, and outdoors to the foundation perimeters, patios, decks, garages and wherever insects are a recurring problem. For indoor surfaces, hold sprayer 12 inches from surface being sprayed and apply a 4-inch wide band, or use a 12-inch wide band when applying outdoors to a home perimeter. Area should be sprayed until slightly wet without soaking. People and pets may re- enter the treated area once sprays have dried. Trust Ortho insect control spray with DIY pest control, home protection and indoor insect control to keep bugs out of your home.

Item Form: Liquid


Liquid Volume: 1 Gallons


Active Ingredients: Bifenthrin, Zeta-Cypermethrin


Brand: Ortho


Target Species: Insects


Brand Name: Ortho


UPC: 071549000622


Part Number: 4660005


Model Number: 4660005


Item Type Name: Insect Killer


Unit Count: 128.0 Fluid Ounces


Included Components: Insect Killer


Manufacturer: Scotts Miracle Gro


Item Form: Liquid


Target Species: Insects


Liquid Volume: 1 Gallons


Active Ingredients: Bifenthrin, Zeta-Cypermethrin


Frequently asked questions

If you place your order now, the estimated arrival date for this product is: Thursday, May 28

Yes, absolutely! You may return this product for a full refund within 30 days of receiving it.

To initiate a return, please visit our Returns Center.

View our full returns policy here.

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Top Amazon Reviews

    • Works Well and Easy to Apply - Good for Preventative Use
Size: 1-Pack Style: Refill
I’ve been using this as a refill for the Ortho Home Defense system, and it’s been working really well. It’s easy to use with the wand, and I like that you can apply it both indoors and around the perimeter of the house without a complicated setup. I haven’t had any issues with leakage. I mainly use it as a preventative treatment, and it does a good job keeping bugs from becoming an issue in the first place. It dries fairly quickly and doesn’t leave a strong smell, which is important when using it inside. The gallon size is a nice quantity and also lasts a while, so it’s a good value if you’re treating multiple areas. I think that this is a reliable option for home pest control that’s simple to apply, effective, and great for keeping bugs under control before they become a problem. ... show more
Reviewed in the United States on April 4, 2026 by Davira’s Discoveries
    • Best Preventative Eradicator
Size: 1-Pack Style: Refill
I've used this stuff for years by way of an old roommate who swore by it. It works so well, safe indoors even with pets, you just have to let it dry first. I use it inside and outside to keep the critters away. I have even recommended this to loved ones who tried "everything" for a recurring bug problem and the next time I visited them, this was in the closet and not a unwelcome creature in sight! ... show more
Reviewed in the United States on April 21, 2026 by Adriana J.
    • Ortho Best Pest Product!!
Size: 1-Pack Style: Refill
Ortho Home Defense is all I've used in the summer months for the past five years. There's no need to call Pest Control, because this product works just as good. I live in Arizona and want to keep the scorpions away. I am amazed how I never see scorpions after I spray this product around the exterior of my home, windows, doorways, etc., just twice during the summer months, as well as interior doorways and garage. ... show more
Reviewed in the United States on April 7, 2026 by BizzeeB
    • Effective Pest Control with Minor Drawbacks
Size: 1-Pack Style: Refill
Ortho Home Defense Insect Killer is a reliable solution for keeping common household pests at bay. It effectively targets ants, roaches, spiders, and other listed insects, providing long-lasting protection when applied correctly. The Home Depot +4 YouTube +4 Amazon +4 ✅ Pros: Effective Pest Control: Kills a wide range of insects, including ants, roaches, spiders, fleas, ticks, scorpions, beetles, silverfish, centipedes, and millipedes. Long-Lasting Protection: Provides up to 365 days of protection on non-porous surfaces. Ease of Application: Comes with a Comfort Wand that allows for easy application without bending or pumping. Amazon Amazon +1 The Home Depot +1 ⚠️ Cons: Mixed Results on Effectiveness: Some users have reported that the product is less effective on certain pests or in specific conditions. Battery Operated Wand Issues: A few customers have experienced issues with the battery-operated spray wand, including short battery life and inconsistent spray patterns. The Home Depot +1 The Home Depot +1 💡 Tips for Best Results: Apply to Entry Points: Focus on spraying around doorways, windows, and other potential entry points to create a barrier against pests. Reapply as Needed: While the product offers long-lasting protection, reapplication may be necessary in areas with high pest activity. The Spruce +7 Ortho +7 Reddit +7 Final Verdict: Ortho Home Defense Insect Killer is a solid choice for homeowners seeking an effective and easy-to-use pest control solution. While there are some minor drawbacks, its overall performance and convenience make it a worthwhile option for maintaining a pest-free home. ... show more
Reviewed in the United States on August 4, 2025 by Gregory Dornbush
    • Easy refill to use
Size: 1-Pack Style: Refill
Love the size of this refill. It is so easy to switch the spray wand form the empty one. I take it camping to put out around my camper for insects. It works great keeping insects out of my camper. There is never any leakage from the container even though I put it in the storge bin when traveling.
Reviewed in the United States on April 17, 2026 by Amazon Customer
    • Great price
Size: 1-Pack Style: Refill
This is the best product available for do it yourself and love that I can spend less getting this refill and reusing old nozzle
Reviewed in the United States on April 19, 2026 by Ashley Wilks
    • My go to
Size: 1-Pack Style: Refill
This stuff never fails, it’s always my go to. I have kids who don’t do well with bugs, and it keeps them out almost all spring and summer. This is the first time I am trying for ants, as I’ve never had an ant problem. So will update after I’ve given it a try for ants. Items delivered on time and was very quick. ... show more
Reviewed in the United States on March 22, 2026 by Karen
    • Great for ants
Size: 1-Pack Style: Refill
I use this around the exterior of my house to control ants. It seems to work better than any others.
Reviewed in the United States on March 31, 2026 by FishLikeAGirl

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