Search  for anything...
Frontline

FRONTLINE Plus Flea & Tick Spot Treatment for Small Breed Dogs 5-22 lbs. (Orange) Count of 3

Based on 49,994 reviews
Condition: New
Checking for the best price...
$40.98
Save $2.01 was $42.99

Buy Now, Pay Later

As low as $10 / mo
  • – 4-month term
  • – No impact on credit to apply
  • – Instant approval decision
  • – Secure and straightforward checkout

Ready to go? Add this product to your cart and select a plan during checkout.

Payment plans are offered through our trusted finance partners Klarna, Affirm, Afterpay, Zip, Apple Pay, and Google Pay. No-credit-needed leasing options through Acima may also be available at checkout.

Learn more about financing & leasing here.

Selected Option

Free shipping on this product

Non-returnable. Transportation of this item is subject to hazardous materials regulation

View our full returns policy here.

Availability: In Stock.
Fulfilled by Amazon
Arrives Friday, Oct 30
Order within 7 hours and 54 minutes

Available payment plans shown during checkout

Protect Your Purchase

Easy claims online, fast replacements, no fees

Checking for protection plans...

Recently Viewed

At a glance

Condition
New
Style
3 Count
Dimensions
5.75 x 0.75 x 4.5 in; 0.8 oz
Weight
22.68 g
Color
Orange Box
Item Form
Liquid
Scent
Orange
In the box
Package includes 3 applicators
Warranty
If you are not satisfied with FRONTLINE Plus for any reason, please contact the Boehringer-Ingelheim Animal Health Customer Care Team at

Features 7

  • The #1 name in flea and tick protection
  • Trusted by pet owners for over 20 years**
  • Fast-acting, long-lasting flea and tick treatment thats waterproof 24 hours after application
  • Protects from fleas and ticks for a full month

Description

Keep your dog protected with the number 1 name in flea & tick protection (1), FRONTLINE. FRONTLINE Plus for Dogs is a fast-acting, long-lasting waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease. Break the flea life cycle — FRONTLINE Plus for Dogs is specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control. Trusted by pet owners for over 20 years (2) — FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply. Applied to a single point on your pet, the flea and tick control treatment covers your dog's entire body and deposits in the sebaceous glands. These glands act as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet. Just one dose of FRONTLINE Plus each month protects against fleas & ticks for a full 30 days. FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products. Appropriately treat all pets in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations. Subscribe and save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus. Be sure to visit our brand store and follow us to stay up to date on new FRONTLINE products, features, tips and more. References: (1) BI Marketing Excellence Survey performed by Kynetec, November 2023. (2) 20 years of trust in killing fleas and ticks demonstrated by various studies in the past 20 years including a 2002 Pet Owner Brand Awareness and Attitude Tracking Study performed by Bruno and Ridgway Research Associates and the 2023 BrandSpark© American Trust Study where FRONTLINE Brand Products were voted most trusted for brand for flea & tick prevention.

Specs 24

Brand Frontline
Item Form Liquid
Scent Orange
Item Weight 22.68 g
Active Ingredients Fipronil 9.8% & (S)-methoprene 8.8%.
Item Volume 264.5 ml
Allergen Information Allergen-Free
Dog Breed Size Small

Frequently asked questions

If you place your order now, the estimated arrival date for this product is: Friday, Oct 30

This item is non-returnable:

Non-returnable. Transportation of this item is subject to hazardous materials regulation

View our full returns policy here.

  • Klarna Financing
  • Affirm Pay in 4
  • Affirm Financing
  • Afterpay Financing
  • Zip Pay in 4
  • Financing through Apple Pay
  • Financing through Google Pay
Leasing options through Acima may also be available during checkout.

Learn more about financing & leasing here.

Similar Products

Top Amazon Reviews

Works well and fast
Style: 3 Count
After trying many natural remedies to get rid of fleas on our yorkie, we decided to finally buy this, and it works. It works fast. There was still some itching for a day or 2 but thats expected with all the bites still being present. Within 3 days I couldn't find 1 flea on him and itching has stopped. If your dog sleeps with you I do recommend putting this on in the morning or giving at least 6hrs for the application area to dry. It does take some time. ... show more
Reviewed in the United States on July 14, 2026 by v-man
Definitely works. Follow the directions.
Style: 3 Count
This is the lest expensive place if you need this product. it works well and is necessary for your dogs comfort and protection. it is important to apply the liquid precisely on the nape of the dogs neck so he can't lick it. It is also imperative to make sure the liquid is applied directly onto the skin and not the fur or hair. It doesn't work immediately and takes a few days to spread so don't panic and apply more if you still notice fleas. They will eventually die. Only apply once every 30 days as directed. I found washing my dog before application works best. ... show more
Reviewed in the United States on May 29, 2026 by ojait2
Skeptical but Flea Free
Style: 3 Count
When we brought our new puppy home, she immediately started scratching like crazy, that’s when we discovered our house had a serious flea problem! I panicked and needed a solution fast. After reading tons of positive reviews, I ordered Frontline and was relieved it arrived quickly. As a bonus, it’s safe for puppies as long as they meet the minimum weight requirement. Application was straightforward, just applied it behind the shoulder blades as directed. **The results:** Within the first day, I could see fleas dying, which was encouraging. However, I’ll be honest, I was a bit concerned when I still spotted 1-2 live fleas daily for the first 48 hours. Based on what I’d heard, I expected faster results. But patience paid off. By day three, the fleas were completely gone and haven’t returned. **Bottom line:** Frontline definitely works, though it takes a full 2-3 days to completely eliminate the problem rather than the overnight miracle I was hoping for. The gradual but thorough elimination was worth it for lasting results. **Would I buy again?** Absolutely. Our puppy is comfortable and flea-free! ... show more
Reviewed in the United States on July 19, 2025 by Monica
Good no great.
Style: 3 Count
Products works good in the sense of stopping fleas from biting. My dog don't scratch as much. It doesn't prevent fleas from hanging around in the fur though. So still have to worry about fleas getting in the house. With all that said, still would recommend.
Reviewed in the United States on May 3, 2026 by Cortez
Very good
Style: 8 Count
Very, very, very well on my dog do not see any fleet bugs or any mosquitoes around him. It worked very well.
Reviewed in the United States on September 19, 2026 by William Campbell
It's a good product for anybody else I need the pills for him
Style: 3 Count
I cannot use the liquid on him because I am allergic to the stuff if I put it on him . I am looking for the pills what is the problem I've been doing this for 2 months and took me this long and my poor dog has been getting fleas and ticks on him.
Reviewed in the United States on September 1, 2026 by Teresa
Don't Buy This. Frontline Plus Does Not Work on Ticks!
Style: 3 Count
For full disclosure this is for 23-44 lb dogs. Yes, I have read about the Frontline mimics on the EPA site (Google Frontline and EPA). My Frontline was bought from Drs. Foster and Smith and did not have the indicators of the fake products. So do not be fooled into thinking all negative reviews of Frontline are about forgeries. I had heard from my vet that fleas were becoming immune to Frontline. I had used Frontline Plus with two previous dogs. I lost my second dog in February 2012 and got a 8 week puppy in April. Frontline had effectively eliminated and prevented any flea infestation for over 20 years, when combined with rug spraying. Since I didn't have fleas to worry about, I was using the remaining Frontline Plus on my puppy when she grew big enough. About 5-10 years previous I had found two ticks on my Frontline Plus treated dog, both dead, neither particularly engorged with blood. Whereas, with a Hertz product I had tried, I found live ticks next to where it was applied. A camping trip October 2012 to Cape Cod proved to me beyond doubt that Frontline Plus also no longer worked on ticks. I was not duly warned by the Nickerson State Campsite how severe their tick problem was. The Frontline Plus had only been on my dog for two weeks. I pulled more than thirty ticks off my dog during the week and the week after I returned. 15 were engorged with more than 7 at what is shown in pictures as fully engorged. Merriel makes a big deal about the tick needing to be on the dog for a certain amount of time before it will kill them. I may be wrong but the length of time seems to be expanding as the effectiveness goes down. At any rate, if it does not kill the tick before the tick can transmit disease, it is worthless. All insecticides come with a risk, and if it doesn't work you are just applying a poison to your beloved companion. My dog contracted a tick-borne disease: Anaplasmosis.(previously Erlichiosis). Due to my persistence, it was caught early, hopefully early enough to prevent long term effects. Testing and treatment for Lyme and Anaplasmosis are not a sure thing. The best course is prevention. Talk to your vet about what is the best out on the market. I was just authorized for refund of the remaining product which I have to mail back. I was told that they can't put an expiration date on the package because EPA doesn't tell them what to put, and they don't know. Even if it was still working, this is very lame for a company that is selling a toxic product. As an afterthought, in flea combing her to locate ticks, I also pulled out two live fleas. Do not buy this product! ... show more
Reviewed in the United States on February 8, 2013 by Moondeer
Frontline Plus
Style: 3 Count
It did not work for us this year. I was very careful to use it on time every month but had found several fleas that have not died.
Reviewed in the United States on August 9, 2026 by Jess F.
How it works
Checking for best price...