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Frontline

FRONTLINE Plus Flea & Tick Spot Treatment for Small Breed Dogs 5-22 lbs. (Orange) Count of 3 | Trusted by pet owners for over 20 years, kills fleas, ticks & chewing lice, waterproof 24 hr

  • Based on 49,515 reviews
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Arrives Tuesday, Aug 25
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Size: 1 Count (Pack of 1)


Features

  • The #1 name in flea and tick protection
  • Trusted by pet owners for over 20 years**
  • Fast-acting, long-lasting flea and tick treatment thats waterproof 24 hours after application
  • Protects from fleas and ticks for a full month
  • Kills adult fleas, flea eggs, flea larvae, ticks, and chewing lice
  • Aids in the control of sarcoptic mange infestations
  • Stops existing flea infestations and prevents establishment of new infestations

Description

Keep your dog protected with the number 1 name in flea & tick protection (1), FRONTLINE. FRONTLINE Plus for Dogs is a fast-acting, long-lasting waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease. Break the flea life cycle — FRONTLINE Plus for Dogs is specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control. Trusted by pet owners for over 20 years (2) — FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply. Applied to a single point on your pet, the flea and tick control treatment covers your dog's entire body and deposits in the sebaceous glands. These glands act as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet. Just one dose of FRONTLINE Plus each month protects against fleas & ticks for a full 30 days. FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products. Appropriately treat all pets in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations. Subscribe and save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus. Be sure to visit our brand store and follow us to stay up to date on new FRONTLINE products, features, tips and more. References: (1) BI Marketing Excellence Survey performed by Kynetec, November 2023. (2) 20 years of trust in killing fleas and ticks demonstrated by various studies in the past 20 years including a 2002 Pet Owner Brand Awareness and Attitude Tracking Study performed by Bruno and Ridgway Research Associates and the 2023 BrandSpark© American Trust Study where FRONTLINE Brand Products were voted most trusted for brand for flea & tick prevention.

Brand: Frontline


Item Form: Liquid


Scent: Orange


Item Weight: 22.68 g


Active Ingredients: Fipronil 9.8% & (S)-methoprene 8.8%.


Item Volume: 264.5 ml


Allergen Information: Allergen-Free


Dog Breed Size: Small


Unit Count: 1 Count


Color: Orange Box


Product Dimensions ‏ : ‎ 5.75 x 0.75 x 4.5 inches; 0.8 ounces


Item model number ‏ : ‎ 74273


Department ‏ : ‎ Flea & Tick


Date First Available ‏ : ‎ October 2, 2001


Manufacturer ‏ : ‎ Boehringer Ingelheim Animal Health


Best Sellers Rank: #285 in Pet Supplies (See Top 100 in Pet Supplies) #4 in Dog Flea Drops


#4 in Dog Flea Drops:


Customer Reviews: 4.4 4.4 out of 5 stars (49,515)


Brand Name: Frontline


Unit Count: 1 Count


Age Range Description: All Life Stages


UPC: 010756261365 350604287001


Global Trade Identification Number: 01


Included Components: Package includes 3 applicators


Item Type Name: Flea and Tick Treatment for Dogs Small Dogs


Manufacturer: Boehringer Ingelheim Animal Health


Model Number: 74273


Manufacturer Part Number: P004FLTSP-0-22


Warranty Description: If you are not satisfied with FRONTLINE Plus for any reason, please contact the Boehringer-Ingelheim Animal Health Customer Care Team at


Item Form: Liquid


Scent Name: Orange


Dog Breed Size: Small


Target Species: Dog


Item Weight: 22.68 g


Volume: 264.5 ml


Allergen Information: Allergen-Free


Active Ingredients: Fipronil 9.8% & (S)-methoprene 8.8%.


Frequently asked questions

If you place your order now, the estimated arrival date for this product is: Tuesday, Aug 25

This item is non-returnable:

Non-returnable. Transportation of this item is subject to hazardous materials regulation

View our full returns policy here.

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Similar Products

Top Amazon Reviews

    • Definitely works. Follow the directions.
Size: 1 Count (Pack of 1)
This is the lest expensive place if you need this product. it works well and is necessary for your dogs comfort and protection. it is important to apply the liquid precisely on the nape of the dogs neck so he can't lick it. It is also imperative to make sure the liquid is applied directly onto the skin and not the fur or hair. It doesn't work immediately and takes a few days to spread so don't panic and apply more if you still notice fleas. They will eventually die. Only apply once every 30 days as directed. I found washing my dog before application works best. ... show more
Reviewed in the United States on May 29, 2026 by ojait2
    • Reliable Protection for Small Dogs – Easy to Use and Works Fast
Size: 1 Count (Pack of 1)
I’ve been using FRONTLINE Plus for my small dog (around 12 lbs) and I’m honestly very impressed with the results. The application is super easy — just a quick squeeze on the back of the neck and you’re done in seconds. No strong smell and my dog didn’t react negatively at all. Within the first 24–48 hours, I noticed a huge difference. Any fleas were gone, and more importantly, they didn’t come back. We spend a lot of time outdoors, so ticks are always a concern, but this treatment has given me peace of mind. It really works as a preventive solution, not just a quick fix. What I also like is that one application lasts a full month, so you don’t have to constantly reapply or worry. The pack comes with 3 treatments, which is great value for the price and keeps you covered for a few months. Overall, this is a reliable, vet-trusted product that actually does what it promises. Highly recommend for anyone with a small dog who wants an easy and effective flea and tick solution. ... show more
Reviewed in the United States on April 22, 2026 by N. Ferrera
    • Works well and fast
Size: 1 Count (Pack of 1)
After trying many natural remedies to get rid of fleas on our yorkie, we decided to finally buy this, and it works. It works fast. There was still some itching for a day or 2 but thats expected with all the bites still being present. Within 3 days I couldn't find 1 flea on him and itching has stopped. If your dog sleeps with you I do recommend putting this on in the morning or giving at least 6hrs for the application area to dry. It does take some time. ... show more
Reviewed in the United States on July 14, 2026 by v-man
    • Failed, after years of successful use
Size: 1 Count (Pack of 1)
I've used Frontline for our dogs and cats for many years now. Used to have a dog that was a tick magnet and Frontline cured that. However, our young dog had increasing scratching over the last week, and we found a live flea on his belly ... this was 2 weeks after his most recent Frontline application. Really disappointed and frustrating. After hours of work cleaning bedding, rugs, bathing dog, etc. etc, I'm hesitant to use this product again and will see what my vet thinks. Would have given it 5 stars before this incident, FWIW. ... show more
Reviewed in the United States on April 27, 2026 by KSpringer
    • Great product
Size: 1 Count (Pack of 1)
Review Image by Richie M.
The perfect product for your fur baby. I've been using this product on my 12 lb Shih Tzu for 10 years. Never an issue never a side affect. I use it on her every 3 months but I also live in a city. But if you are more in wooded or park area I would do it every month personally. But overall amazing product. Thanks ... show more
Reviewed in the United States on July 16, 2026 by Richie M.
    • Frontline Flea and Tick Prevention
Size: 1 Count (Pack of 1)
Works great for pur dog. She will mot take pills or eat thechews for flea and tick prevention. This is easy to apply and it is not a battle to get her to take any oral medicine.
Reviewed in the United States on June 30, 2026 by Debby Abshier
    • Buyer Beware! Counterfeit / Fraudulent Products
Size: 1 Count (Pack of 1)
This review may be quite lengthy, but as an Amazon consumer, I recommend that you thoroughly read and understand this review, as I guarantee it to be worth your time and the health and safety of your pet. Frontline Plus for Dogs when packaged and sold properly (by most Veterinarians and most reputable companies) works as it is described to work. For those instances, I would give the product a 5 star rating. But being that this is a consumer review of Frontline Plus for Dogs for the marketplace of Amazon, I would like to bring a particular experience that I became a victim of, to the attention of the consumer. Merial produces the product named Frontline Plus for Dogs (of various weights) for US consumers and for the consumers in International markets. Products produced for US distribution are EPA approved. Products for International markets, are not EPA approved. EPA, in this instance, stands for Environmental Protection Agency. This agency sets and enforces rules and standards that protect the environment and control pollution. If a manufacturer produces and distributes EPA and non EPA approved products, it seems like a safer option to administer the EPA approved product. Here goes the story of how I fell victim to a fraudulent sale of Frontline Plus for Dogs through a Seller / Store utilizing Amazon: Upon receipt of a Merial Frontline Plus for Dogs product from a Seller / Store on Amazon, the packaging appeared identical to those sold by my previous Veterinary purchase as well as a previous purchase of this product from Amazon directly. While the outside appeared legit, the inside contents had me on alert instantaneously. Here are a few of the red flags that came to mind: 1) The inside contents did not contain the stickers for the consumer to mark their calendar on usage dates. 2) The back of the sealed vials stated the product as Frontline Combo and not as Frontline Plus for Dogs. 3) The back of the sealed vials displayed three rows of orange that read as follows: "AD US. VET - USAGE VETERINAIRE - FOR VETERINARY USE." 4) The plastic vials contained a pull like backing as opposed to the difficult plastic tab opening that most consumers avoid and end up puncturing the seal to pull the vial from the individual packaging. 5) The sealed area of each vial shows individually, Fipronil 10% w/v, MethroPrene 9% w/v, and 0.67 ml. (I do not recall my previous vials ever showing these figures) 6) The lot number that can be found on the outside of the box contains a lot number that is different from the lot number listed on the back of each of the inside vials. I made the decision to not use this product on my pet and contacted the US 800 number for Merial, the manufacturer. After explaining the item that arrived to the representative, I was provided some interesting information that confirmed that my intuition of the product I received was correct and that this product was non-other than a fraudulent product that needed to be returned to the Seller / Store that sold this item to me through the use of Amazon. I gathered the following information from the representative at Merial: 1) The box is a US EPA approved Frontline Plus for Dogs. 2) The contents are not EPA approved as it contained vials for a different country. 3) The lot numbers on the box and vials are not consistent, when they should be. This product that I fell victim to was a foreign label product and when questioning the representative as to what she would do if she had this item on hand, she said that she would not use the item and request a refund because foreign label products are not EPA approved. So, as the title of my review states, "Buyer Beware", please beware and pay close attention to the product that you are receiving. If key points that I have listed in my review clearly identify your item that you received as a foreign label product, please contact the Seller / Store and request to process the return of the item immediately. Pets are like family, the last thing that I believe you should administer to your pet is a non EPA approved product. Additionally, if a consumer is sold a counterfeit / fraudulent item through Amazon's Marketplace, the consumer should report it to Amazon. These fraudulent Sellers / Stores don't belong on Amazon and the only way that we can initiate an investigation and seek their removal is to report each counterfeit situation to the attention of Amazon directly and warn potential consumers of these fraudulent Sellers / Stores. I had some issues initially handling my return with the Seller. I refused to pay to ship the counterfeit / fraudulent items (that shouldn't have been sold to me in the first place) back and I insisted that the Seller either pay for the postage and tracking of the products or refund it to me with the refund of my original purchase (Including my original shipping costs). The Seller after multiple email communications emailed me a prepaid USPS mailing label with tracking. I was hesitant on naming the fraudulent Amazon Marketplace Seller / Store until my entire return was processed and refunded. Now that my refund was successful, the fraudulent Frontline Plus that was sold to me was sold through the Amazon Marketplace Seller / Store of Discount Flea. The return address company name was Doc's Discount Flea Control located in Las Vegas, NV. The front of their sold product contains a sticker that refers you to re-order from unitedpetmeds2010.com with a 10% discount off of an order of $100 or more. I do not recommend purchasing these products from any of these companies. I would also be wary of any other company that you receive items that look as I described and suggest requesting an immediate return and issuing a complaint to Amazon of the fraudulent Seller / Store that you encountered. ... show more
Reviewed in the United States on October 16, 2012 by MsK
    • Not Effective
Size: 6 count
This product didn’t seem to work with our small dachshunds. After application, they continued scratching and the fleas stuck around. We ended up needing to take them to the vet for treatment. The vet said that the fleas are becoming resistant to this product and we needed a prescription strength flea medication to kill off these super fleas. This product was not useful to us and I don’t recommend it to others. ... show more
Reviewed in the United States on January 27, 2026 by Moyer

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