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Frontline

FRONTLINE Plus Flea & Tick Spot Treatment for Large Breed Dogs 45-88 lbs. (Purple) Count of 3 | Count of 3, Trusted by pet owners for over 20 years,² kills fleas, ticks & chewing lice, waterproof 24 hr

  • Based on 50,501 reviews
Condition: New
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Size: 11.46 Fl Oz (Pack of 1)


Features

  • The #1 name in flea and tick protection
  • Trusted by pet owners for over 20 years**
  • Fast-acting, long-lasting flea and tick treatment thats waterproof 24 hours after application
  • Protects from fleas and ticks for a full month
  • Kills adult fleas, flea eggs, flea larvae, ticks, and chewing lice
  • Aids in the control of sarcoptic mange infestations
  • Stops existing flea infestations and prevents establishment of new infestations

Description

Keep your dog protected with the number 1 name in flea & tick protection (1), FRONTLINE. FRONTLINE Plus for Dogs is a fast-acting, long-lasting waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease. Break the flea life cycle — FRONTLINE Plus for Dogs is specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control. Trusted by pet owners for over 20 years (2) — FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply. Applied to a single point on your pet, the flea and tick control treatment covers your dog's entire body and deposits in the sebaceous glands. These glands act as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet. Just one dose of FRONTLINE Plus each month protects against fleas & ticks for a full 30 days. FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products. Appropriately treat all pets in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations. Subscribe and save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus. Be sure to visit our brand store and follow us to stay up to date on new FRONTLINE products, features, tips and more. References: (1) BI Marketing Excellence Survey performed by Kynetec, November 2023. (2) 20 years of trust in killing fleas and ticks demonstrated by various studies in the past 20 years including a 2002 Pet Owner Brand Awareness and Attitude Tracking Study performed by Bruno and Ridgway Research Associates and the 2023 BrandSpark© American Trust Study where FRONTLINE Brand Products were voted most trusted for brand for flea & tick prevention.

Brand: Frontline


Item Form: Liquid


Scent: Unscented


Item Weight: 18.14 g


Active Ingredients: fipronil and (S)-methoprene


Item Volume: 339 ml


Allergen Information: Abalone Free


Dog Breed Size: Large


Unit Count: 1 Count


Color: Purple Box


Product Dimensions ‏ : ‎ 5.75 x 0.75 x 4.5 inches; 0.64 ounces


Item model number ‏ : ‎ 72219


Department ‏ : ‎ Insect Control


Date First Available ‏ : ‎ September 2, 2004


Manufacturer ‏ : ‎ Boehringer Ingelheim Animal Health


Best Sellers Rank: #247 in Pet Supplies (See Top 100 in Pet Supplies) #3 in Dog Flea Drops


#3 in Dog Flea Drops:


Customer Reviews: 4.4 4.4 out of 5 stars (50,501)


Brand Name: Frontline


Unit Count: 1 Count


Age Range Description: All Life Stages


UPC: 350604287209 666672366389


Global Trade Identification Number: 09


Included Components: Package includes 3 applicators


Item Type Name: Topical Purple box


Manufacturer: Boehringer Ingelheim Animal Health


Model Number: 72219


Manufacturer Part Number: P004FLTSP-45-88


Warranty Description: only for dog


Item Form: Liquid


Scent Name: Unscented


Dog Breed Size: Large


Target Species: Dog


Item Weight: 18.14 g


Volume: 339 ml


Allergen Information: Abalone Free


Active Ingredients: fipronil and (S)-methoprene


Frequently asked questions

If you place your order now, the estimated arrival date for this product is: Tuesday, Sep 1

This item is non-returnable:

Non-returnable. Transportation of this item is subject to hazardous materials regulation

View our full returns policy here.

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Similar Products

Top Amazon Reviews

    • Tried and true product for Lyme disease prevention
Size: 6 Count
Tried and true product. As a general rule, I do not like having to put chemicals on my dogs. But we live in an area where the ticks are atrocious and some years are worse than others. So I struggle with putting chemicals on the dogs versus having them contract Lyme disease so I do use this product when I feel that I have to. I have never had a dog have a reaction to Frontline, and we have had dogs for 25 years. It works immediately. I wish they would come out with a product like this for people. I had a tick crawling down my neck the other day and it really freaked me out. Good price and fast shipping. ... show more
Reviewed in the United States on August 9, 2025 by Amazon Customer
    • Happy
Size: 3 Count
Doesn’t work for me anymore but it is a good thing
Reviewed in the United States on June 25, 2025 by Sarah Bristol
    • Flea and Tick
Size: 3 Count
I put it on my dogs every month and it works perfectly. I have dogs with sensitive skin and it doesn't break them out so no skin irritation, easy to put on them with no stress, has no smell, also no fleas, and safe for my other dogs and it's durable.
Reviewed in the United States on August 13, 2025 by Karsyn Arflack
    • Your Safest Bet For A Product You Wish You Didn't Need.
Size: 6 Count
Allow me to caveat this review by saying out of 700 plus reviews this is the most difficult to write as I despise having to use pesticides on our dogs. That said, we live in Tick and Flea central, surrounded by deep woods and our bulldogs are in every sense of the word family and we do whatever we must to protect them. That said if you're reading these reviews your dog or dogs are your heart too and using these products is a difficult choice to make, but it's one we have to make. On that note, it's my hope the following information has some value for you. Frontline was first put into clinical trials in 1985 shortly after the discovery of it's active ingredient Fipronil. To it's credit Frontline has maintained the safest albeit not the most effective treatment for fleas and ticks. However, the more effective products pose a significantly greater risk to your dog. It's a slippery slope, but in evaluating what's best for your dog by providing the highest level protection with the lowest risk Frontline and FrontLine Plus are in my opinion your best bet. Most tick and flea products contain Permethrin which may also be listed as Lyclear or Nix as the active ingredient. Permethrin is a lethal neurotoxin that flows through the dogs circulatory system and flushes into every major organ - including the brain where it can do dire damage. Thousands of dogs die every year from Permethrin. Although the FDA has mandated a minimal use not to exceed 750PPM companies continue to ignore the guidline because it's cheap and effective, and sadly it's our dogs that pay the price. What makes Permethrin so dangerous is that it can't distinguish between insects and mammals which of course includes human beings. It's been known to be lethal to cats since the 1970's. In fact it's so deadly to cats that even a slight transfer from dog to cat can result in seizures, brain damage and death. Permethrin is volatile as well - meaning it's airborne properties pose a threat to all who breath it in - humans included. Frontline on the other hand uses Fipronil. Fipronil is an insecticide. Like any chemical of this nature it can be lethal at too high of a dose. However studies including those from the Department of Environmental Conservation have determined time and time again that as long as the amount of Fipronil is at the correct dose for the weight and size of your dog toxicity is far easier to avoid and the product much safer for your dog. Unlike Premethrin, Fipronil is absorbed into the hair follicles and oil glands only. It is not absorbed into the dogs system nor is it volatile so you and your beloved pets and children can breath easy. The second active ingredient in FrontLine Plus is Methoprene which is a long existing and time proven IGR (insect growth regulator) it's distributed exactly like Fipronil but only acts on flea and tick eggs and Larvae - this is important because it kills these vermin at the start of a new life cycle. What is more, the diseases that ticks carry now are infinitely more serious than the dreaded Lime disease - which for decades was the only concern. Competitors to Frontline (and some Vets selling other products) claim that fleas and ticks have become resistant to Frontline - However these pests have become resistant to some degree to all pesticides and no independent research exists to confirm this claim. I can assure you I've researched this in the greatest depth. The bottom line is this - all of these products pose a risk. The wise choice is to minimize that risk in your effort to protect your best friend from the diseases these vermin carry. Again, these diseases can be infinitely more lethal than the ingredients of the protection. To that end your safest and most effective choice is Frontline or Frontline Plus. In the event your pet has a bad reaction to Frontline products these are the symptoms you would see: * Restlessness * Itching * Vomiting * Difficulty Breathing * Lethargy Should these symptoms occur, of course take your pet to your Veterinarian or emergency clinic immediately. It should be a comfort to know that unlike the toxic ingredients in most other flea and tick control products severe reactions to both Fipronil and Methoprene are rare. ... show more
Reviewed in the United States on August 18, 2012 by Peter Suslock
    • If you don't like fleas and ticks frontline is a excellent product
Size: 6 Count
This product works really well. Use it on 2 dogs. A little pricey but worth it. Arrives on time. No problems with this seller or product. Easy to apply.
Reviewed in the United States on August 12, 2025 by Kindle Customer
    • Very effective
Size: 6 Count
Been using it on all my dogs for over a year. Very very effective. (My dogs are inside and we don't do fleas). Doesn't have strong smell (I've never noticed any smell), very easy to use, just open the receptacle, part the hair and apply to the correct area.
Reviewed in the United States on August 22, 2025 by Amelia
    • Didn't prevent fleas but Seresto collar did
Size: 3 Count
The Frontline Plus flea and tick control for 45 to 88 pound dogs was worse than a disappointment. My dog is 50 pounds--well within the dosage range and become infested with fleas during the second month/dosage of usage. I'm not sure if the preventative actually worked the first month or if I just didn't notice the fleas until the fleas had multiplied enough for me to easily see them. I also don't know if I received the same quailty Frontline product through Amazon as a store/vet purchase. I have no reason to think that this was an imitation product other than some suspicions by other reviewers. Regardless, I had to use a flea dip and flea bomb my house. Once an infestation occurs, getting rid of the fleas is quite an aggravation. I'm trying Advantage II from PetSmart now to see if that will work. Hopefully, something will. June 24 2013, Advantage II didn't work either. I've had acceptable success from Certifect which I buy from my vet. I've used Certifect for over a year now. These flea and tick drops are made by Frontline but are only sold by prescription or thru a vetinarian. It works great for ticks. I've not had any problems with ticks from the first dosage. For a few days, though, after the dosage, he is a bit lethargic. However, my dog will still pick up fleas. The drops do kill the fleas but don't repel them quickly enough. Many people are having trouble with fleas because of the sucession of mild winters. The flea population isn't culled enough. During the summer months, the fleas just seem to overwhelm the medication and flea dips or additional organic sprays are necessary. I've been told that a new flea and tick pill may now be available. I know the flea pill works but I hadn't used it because I needed something for ticks. If this rumor is true, I'll definately give the pill a try. December 30, 2014. I finally found something that actually works for controlling fleas and ticks for my now 70 pound Labrador/mix. (He was a stray that my family adopted--short hair.) My vet introduced me to a new product (at the time) made by Bayer. It's a flea collar called Seresto that is sold on Amazon. I couldn't believe that a flea collar would really work. But, after having to hire Orkin to get the fleas out of my home, I was willing to try it. It's the best product that I have used for fleas and ticks. It's easy to use. I just put the collar on my dog. In few days all fleas were gone. The only ticks I ever find on my dog are the ones that he picks up during a walk or bush adventure. They are easily brushed off (when I notice them) and never attach. The collar lasts as long as advertised--8 months or in our case 5 months since he likes to swim. Unlike the drops, he is never lethargic afterwards. I have used several of these Seresto collars now and can't recommend them enough. They are sold on Amazon, by veterinarians, and I've seen them at Pet Smart as well. ... show more
Reviewed in the United States on April 28, 2012 by Sheryl
    • Overall good product
Size: 3 Count
Effectiveness is to be determined, just put it on my dogs yesterday. No smell from the product. Overall a very comfortable process for me and my dogs. Flea control is also TBD. Very easy to use product and packaged as advertised. Only thing is that is does take quite a while to dry, especially if you have a densely haired dog. ... show more
Reviewed in the United States on July 14, 2025 by Lilly

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