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Differin

Differin Acne Retinoid Treatment Gel, 0.1% Adapalene, 45g Pump | 90-Day Supply Pump, Over-The-Counter Retinoid, Clears Breakouts, Gentle For Sensitive Skin, Dermatologist Recommended

  • Based on 10,526 reviews
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Availability: In Stock.
Fulfilled by Amazon
Arrives Wednesday, Aug 5
Order within 8 hours and 51 minutes
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Style: Single-Dose Pump


Size: 45g (90 Day Supply)


Features

  • TARGETS ACNE: Clear and prevent acne with the first FDA-approved prescription strength over-the-counter acne retinoid
  • CLEARS, TREATS & PREVENTS: Differin works differently than other Acne treatments by normalizing skin cell turnover and effectively targets two primary causes of Acne, clogged pores and inflammation
  • RX STRENGTH ACNE RETINOID: Adapalene was created for superior tolerability compared to other prescription retinoid products not containing Adapalene; It is suitable for use as part of your morning or evening regimen
  • DERMATOLOGIST RECOMMENDED: Water based formula, oil free, alcohol free, fragrance free, non comedogenic; Helps reduce the risk of scarring and Hyperpigmentation by treating Acne
  • REAL RESULTS: In a clinical study, Differin gel provided up to 87 percent reduction in acne breakouts after 12 weeks, which will continue to improve with further use
  • THE CREATORS OF ADAPALENE: A Retinoid that Fights Acne

Description

Differin Gel Acne Treatment contains adapalene, an Rx-strength acne-fighting retinoid that helps clear breakouts where they start (works deep into pores in 5 minutes), helps prevents new acne from forming, and as a result, can restore skin�s overall tone and texture. Adapalene is the first over-the-counter active ingredient for acne in more than 30 years. It clears acne with the power of an Rx without the prescription, prevents breakouts, blackheads, whiteheads, blemishes and clogged pores, and can be used to effectively treat acne, or maskne, caused by wearing face masks or facial coverings. When used as directed, you could start to see results in as little as 1 week, and when used every single day, Differin Gel can help reduce up to 87% of acne in just 12 weeks (Cunliffe et al 1998, Galderma Laboratories).

Product Dimensions ‏ : ‎ 1.69 x 2.8 x 7 inches; 1.59 ounces


Item model number ‏ : ‎ 0299.491040


Department ‏ : ‎ Beauty & Personal Care


UPC ‏ : ‎


Manufacturer ‏ : ‎ Galderma


Best Sellers Rank: #239 in Beauty & Personal Care (See Top 100 in Beauty & Personal Care) #1 in Facial Skin Care Sets & Kits


#1 in Facial Skin Care Sets & Kits:


Customer Reviews: 4.6 4.6 out of 5 stars (10,526)


Item Form: Gel


Scent Name: Unscented


Product Benefits: Anti-Acne


Skin Type: Acne-Prone, Combination, Normal


Special Ingredients: Retinoid


Target Use Body Part: Face


Active Ingredients: Adapalene 0.1%


Container Type: Bottle


Brand Name: Differin


Set Name: Style/Size Set


Unit Count: 1.6 Ounce


Global Trade Identification Number: 03


UPC: 302994910403


Item Type Name: Retinoid


Manufacturer: Galderma


Model Number: 0299.491040


Manufacturer Part Number: 0299.491040


Item Weight: 45 g


Size: 45g (90 Day Supply)


Package Size Name: 90 Day Supply


Material Features: Fragrance Free, Non-Comedogenic


Frequently asked questions

If you place your order now, the estimated arrival date for this product is: Wednesday, Aug 5

Yes, absolutely! You may return this product for a full refund within 30 days of receiving it.

To initiate a return, please visit our Returns Center.

View our full returns policy here.

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Similar Products

Top Amazon Reviews

    • Reliable Long-Term Acne Treatment That Works With Consistent Use
Review Image by LeafyReviews
Review Image by LeafyReviews
I’ve been using Differin Gel for years, and it’s a staple in my routine. This is one of the few acne treatments I consistently repurchase because it actually helps when used correctly and patiently. Differin works by regulating skin cell turnover, so results are gradual rather than overnight. If you’re starting for the first time or restarting after a long break, it’s normal to experience an initial breakout phase as your skin adjusts. In my experience, this settles with continued, consistent use, and overall breakouts become less frequent and less severe over time. The gel itself is lightweight, fragrance-free, and easy to incorporate into an evening routine. A thin layer goes a long way. I also find it’s best used as part of a simple, gentle skincare routine, especially since this type of product can make skin feel more sensitive at first. I keep this on hand at all times and reorder it regularly. One downside is that the price fluctuates on Amazon, so I usually wait to restock when it drops. Overall, this is a solid option for anyone looking for a long-term acne treatment rather than a quick fix. It takes patience, but it’s been very reliable for me over the years. Pros: - Effective with consistent, long-term use - Lightweight, non-greasy gel - Fragrance-free and easy to layer into a routine -One pump lasts a long time Cons: - Adjustment period can cause temporary breakouts - Skin may feel more sensitive at first - Price fluctuates ... show more
Reviewed in the United States on January 26, 2026 by LeafyReviews
    • Go slow and low and moisturize!
I Have sensitive skin and occasional hormonal acne. Pores on T zone are enlarged. I’ve used it once so far 2 days ago and wow! It made a huge difference. I had a lot of advice to go low and slow and use moisturizer before and after it. So far no redness or irritation I am going to use it 2 times to 3 times a week, at night and see how the “journey” goes. My skin felt so soft, my pores, barely there. I hope to update this at a later date with more results but seeing visible evidence after 1 use is quite rare. ... show more
Reviewed in the United States on July 2, 2026 by Jacqueline Sanchez
    • Great product
This is a great product for acne. It’s a gel texture and it absorbs fast into your skin. It does not leave your skin feeling greasy or sticky. It also pairs well with other skincare products. This product is gentler than tretinoin but still gives you the same effect. I was very alarmed with the comments about how many people complained about peeling.It’s a retinol so yes there will be purging and or peeling for a few weeks until your skin gets used to it. This varies from person to person. I suggest using a thicker moisturizer at night to combat the peeling. ... show more
Reviewed in the United States on July 13, 2026 by alexandria rooks
    • The acne treatment everyone needs
This acne treatment gel works quickly to reduce breakouts while helping to calm redness and irritation. I find it very easy to apply, absorbs well, and leaves my skin looking clearer with consistent use.
Reviewed in the United States on June 26, 2026 by Tracy
    • Dries skin slightly
I’ve been using Differin Acne Treatment Gel for a while now, and it does a solid job keeping breakouts under control. With consistent use, I’ve noticed smoother skin and fewer flare-ups. The downside is that it can be pretty drying, especially at the beginning, so a good moisturizer is a must. Overall, it works well if you stick with it—solid 4 stars. ... show more
Reviewed in the United States on April 6, 2026 by Mandarella
    • Works Fast!
I absolutely love this stuff. My skin type is oily and id say my family has had bad acne genes... But this stuff has made my skin smoother, clears up acne FAST, and is easy to apply. I had a bad pimple just on my upper lip and in my attempt to drain it, it started to get inflamed and swollen... I was freaking out but after applying this stuff and ice to it, it was nearly normal the next day then on the third day completely fine. Absolute life saver! ... show more
Reviewed in the United States on July 8, 2026 by Kaitlyn
    • Buy it!
This stuff is AMAZING. I don't know why I've waiting so long to try something like this (I'm in my 40's). I had asked what could help my complexion and this was suggested to me. I put it on my forehead and T-zone every other day as it made the area around my eyes mad. I do see a noticeable difference in skin texture and complexion. Overall, it just feels softer. Buy it. ... show more
Reviewed in the United States on July 9, 2026 by Eden
    • Love Differin
I first got this when it was prescribed by a doctor and have been using it on and off since. It works very well for my skin. Your skin might have to get used to it, it dried my skin a bit and saw some peeling but then it goes away.
Reviewed in the United States on July 8, 2026 by ElRiv

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