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Differin

Differin Acne Treatment Gel, 90 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 45g Pump (Packaging May Vary)

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Availability: In Stock.
Fulfilled by Amazon
Arrives Thursday, May 21
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Style: Single-Dose Pump


Size: 45g (90 Day Supply)


Features

  • TARGETS ACNE: Clear and prevent acne with the first FDA-approved prescription strength over-the-counter acne retinoid
  • CLEARS, TREATS & PREVENTS: Differin works differently than other Acne treatments by normalizing skin cell turnover and effectively targets two primary causes of Acne, clogged pores and inflammation
  • RX STRENGTH ACNE RETINOID: Adapalene was created for superior tolerability compared to other prescription retinoid products not containing Adapalene; It is suitable for use as part of your morning or evening regimen
  • DERMATOLOGIST RECOMMENDED: Water based formula, oil free, alcohol free, fragrance free, non comedogenic; Helps reduce the risk of scarring and Hyperpigmentation by treating Acne
  • REAL RESULTS: In a clinical study, Differin gel provided up to 87 percent reduction in acne breakouts after 12 weeks, which will continue to improve with further use
  • THE CREATORS OF ADAPALENE: A Retinoid that Fights Acne

Description

Differin Gel Acne Treatment contains adapalene, an Rx-strength acne-fighting retinoid that helps clear breakouts where they start (works deep into pores in 5 minutes), helps prevents new acne from forming, and as a result, can restore skin�s overall tone and texture. Adapalene is the first over-the-counter active ingredient for acne in more than 30 years. It clears acne with the power of an Rx without the prescription, prevents breakouts, blackheads, whiteheads, blemishes and clogged pores, and can be used to effectively treat acne, or maskne, caused by wearing face masks or facial coverings. When used as directed, you could start to see results in as little as 1 week, and when used every single day, Differin Gel can help reduce up to 87% of acne in just 12 weeks (Cunliffe et al 1998, Galderma Laboratories).

Product Dimensions ‏ : ‎ 1.69 x 2.8 x 7 inches; 1.59 ounces


Item model number ‏ : ‎ 0299.491040


Department ‏ : ‎ Beauty & Personal Care


UPC ‏ : ‎


Manufacturer ‏ : ‎ Galderma


Customer Reviews: 4.6 4.6 out of 5 stars (10,204)


Item Form: Gel


Scent Name: Unscented


Product Benefits: Anti-Acne


Skin Type: Acne-Prone, Combination, Normal


Special Ingredients: Retinoid


Target Use Body Part: Face


Active Ingredients: Adapalene 0.1%


Container Type: Bottle


Brand Name: Differin


Set Name: Style/Size Set


Global Trade Identification Number: 03


UPC: 302994910403


Manufacturer Part Number: 0299.491040


Model Number: 0299.491040


Unit Count: 1.6 Ounce


Manufacturer: Galderma


Item Type Name: Retinoid


Item Weight: 45 Grams


Size: 45g (90 Day Supply)


Material Features: Fragrance Free, Non-Comedogenic


Frequently asked questions

If you place your order now, the estimated arrival date for this product is: Thursday, May 21

Yes, absolutely! You may return this product for a full refund within 30 days of receiving it.

To initiate a return, please visit our Returns Center.

View our full returns policy here.

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Top Amazon Reviews

    • Reliable Long-Term Acne Treatment That Works With Consistent Use
Review Image by LeafyReviews
Review Image by LeafyReviews
I’ve been using Differin Gel for years, and it’s a staple in my routine. This is one of the few acne treatments I consistently repurchase because it actually helps when used correctly and patiently. Differin works by regulating skin cell turnover, so results are gradual rather than overnight. If you’re starting for the first time or restarting after a long break, it’s normal to experience an initial breakout phase as your skin adjusts. In my experience, this settles with continued, consistent use, and overall breakouts become less frequent and less severe over time. The gel itself is lightweight, fragrance-free, and easy to incorporate into an evening routine. A thin layer goes a long way. I also find it’s best used as part of a simple, gentle skincare routine, especially since this type of product can make skin feel more sensitive at first. I keep this on hand at all times and reorder it regularly. One downside is that the price fluctuates on Amazon, so I usually wait to restock when it drops. Overall, this is a solid option for anyone looking for a long-term acne treatment rather than a quick fix. It takes patience, but it’s been very reliable for me over the years. Pros: - Effective with consistent, long-term use - Lightweight, non-greasy gel - Fragrance-free and easy to layer into a routine -One pump lasts a long time Cons: - Adjustment period can cause temporary breakouts - Skin may feel more sensitive at first - Price fluctuates ... show more
Reviewed in the United States on January 26, 2026 by LeafyReviews
    • Great and Effective Acne Gel
This acne gel has worked really well for my sons. After using it consistently, they noticed a visible improvement in breakouts and redness. It helps dry out pimples quickly without being too harsh on their skin. The gel goes on smoothly, absorbs fast, and doesn’t leave them with a greasy feeling. They’ve definitely seen clearer skin since starting to use it! ... show more
Reviewed in the United States on April 18, 2026 by Amazon Customer
    • Effective Acne Treatment That Works Gently Over Time
I’ve been using Differin Acne Treatment Gel consistently, and it’s one of the most effective acne products I’ve tried, especially for long-term results. The 0.1% adapalene formula feels lightweight and spreads easily, and the pump packaging makes it simple to dispense the right amount without waste. What I appreciate most is how gentle it is compared to other retinoids. When I first started, I eased into it, and while there was some mild dryness, it was manageable and temporary. With regular use, my skin adjusted well, and I started noticing fewer breakouts and smoother texture overall. It doesn’t feel harsh or irritating when used properly, which is a big plus for sensitive or acne-prone skin. Over time, Differin has helped reduce clogged pores and the frequency of new breakouts. It’s not an overnight fix, but with patience and consistency, the results are real and noticeable. It layers well with moisturizer and doesn’t pill, making it easy to fit into a nighttime routine. Overall, this is a reliable, dermatologist-recommended acne treatment that delivers results without being overly aggressive. If you’re looking for a proven retinoid that works gradually and gently, Differin is a solid choice and well worth sticking with. ... show more
Reviewed in the United States on January 6, 2026 by Sean Bozarth
    • Dries skin slightly
I’ve been using Differin Acne Treatment Gel for a while now, and it does a solid job keeping breakouts under control. With consistent use, I’ve noticed smoother skin and fewer flare-ups. The downside is that it can be pretty drying, especially at the beginning, so a good moisturizer is a must. Overall, it works well if you stick with it—solid 4 stars. ... show more
Reviewed in the United States on April 6, 2026 by Mandarella
    • don't give up - your dream skin is on the other side of your perserverance!
This stuff is pure magic. it took about 3 months for my skin to fully adjust and for me to use nightly now without issues. i use to get a few annoying pimples around the time i ovulate. in my mid-30s i started developing hormonal acne along my chin. it's all completely gone away once i fully adjusted to Differin. i don't get pimples anymore and my brother even noticed my skin had a really nice glow to it (brothers aren't usually complimentary). if this is your first time trying a strong retinoid, expect the adjustment period to be rough - lots of dryness, flaking, irritation. if you have a history of bad acne, expect the acne to get worse before it gets better. don't force it, take 2 or 3 days off if the irritation gets bad, but consistency is key. and most importantly - patience and don't give up! your dream skin is on the other side of your perserverance. ... show more
Reviewed in the United States on April 2, 2026 by iamiyu
    • Work great Highly reccomend
This product has worked great for my skin. It’s made my face noticeably clearer and has significantly improved my skin texture over time. The pump dispenser is also really useful because it helps me apply a consistent amount every day, which makes sticking to a routine much easier. Overall, this has been one of the most effective acne treatments I’ve used. ... show more
Reviewed in the United States on May 12, 2026 by Peter Brown
    • You'll be pleased with the RESULTS!
Excellent product by an excellent company. I believe that in years past, this was only available by prescription, so I'm happy I can now just purchase some whenever. I started using this the day I got it in conjunction with some other well known acne cleansing products and literally saw results overnight. My skin is very pale and very sensitive, so I don't/can't use it daily, but every other day or every 2-3 days is perfect! ... show more
Reviewed in the United States on May 5, 2026 by C. Lewis
    • Stay Patient and Use Sparingly
My son and I are both using this product for slightly different reasons. He is using it to clear and keep acne away and I am using it in an attempt to smooth out some pesky calcium deposits that have formed under my facial skin as a result of old acne. We are both having good luck with it and although it is harsh if used too often and not followed up with a good moisturizer, we are finding it far less harsh than Tretinoin. ... show more
Reviewed in the United States on May 7, 2026 by KLR

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