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Designs for Health

Designs for Health Homocysteine Supreme - Methylated Multivitamin of B Vitamins with Riboflavin, B6, B12, Folate, L-Serine & TMG for Brain Support & Healthy Inflammatory Response (120 Caps)

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Size: 120 Count (Pack of 1)


Features

  • Methylation Support - A modified methylated B complex with L-serine and TMG, which are known to facilitate the efficient metabolism of homocysteine and normal methylation processes in the body.* Intended to promote cardiovascular health, brain function, and healthy imflammatory response.
  • Promotes Heart & Brain Health - An optimally functioning homocysteine pathway plays a role in biochemical reactions, such as detoxification, healthy immune support, ideal joint and cartilage structure, brain health and cardiovascular health.*
  • Premium B Vitamins & TMG for Superior Absorption - Supplies a methylated folate and B12 supplement, along with P5P vitamin B6 and riboflavin. Includes Trimethylglycine to support normal methylation.*
  • Vegetarian & Non-GMO - Vegetarian-friendly and made without soy, gluten, GMOs or soy. Take 2 capsules per day with meals or as directed by your health-care practitioner.
  • Clinically-Trusted Care - DFH is the #1 practitioner supplement brand recommended by functional medicine professionals and the #1 practitioner supplement brand personally trusted by functional medicine professionals.**

Description

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Visit the Store Visit the Store Visit the Store

Is Discontinued By Manufacturer ‏ : ‎ No


Product Dimensions ‏ : ‎ 3 x 3 x 5 inches; 0.04 ounces


Date First Available ‏ : ‎ July 26, 2021


Manufacturer ‏ : ‎ Designs for Health


Best Sellers Rank: #7,747 in Health & Household (See Top 100 in Health & Household) #148 in Blended Vitamin & Mineral Supplements


#148 in Blended Vitamin & Mineral Supplements:


Customer Reviews: 4.8 4.8 out of 5 stars (947)


Brand Name: Designs for Health


Item Form: Capsule


Primary Supplement Type: Methylation Support Capsules


Diet Type: Gluten Free, Vegetarian


Flavor: Unflavored


Product Benefits: Heart Health Support


Age Range Description: Adult


Specific Uses For Product: Brain


Special Ingredients: B Vitamins, TMG, L-serine


Number of Items: 1


Container Type: Bottle


Dosage Form: Tablet


UPC: 879452006683


Manufacturer: Designs for Health


Manufacturer Part Number: HYS120-AZ


Unit Count: 120 Count


Item Weight: 1000 Milligrams


Item Dimensions: 3 x 3 x 5 inches


Material Type Free: Dairy Free, GMO Free, Soy Free


Frequently asked questions

If you place your order now, the estimated arrival date for this product is: Thursday, Aug 20

This item is non-returnable:

Non-returnable due to Food safety reasons

View our full returns policy here.

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Top Amazon Reviews

    • Research on brand checked out as did ingredients!
Size: 120 Count (Pack of 1)
I did a lot of research on this brand as I’ve never purchased supplements from them before. Everything checked out as reputable. The dosages are correct for what I need. If I find they don’t work, I’ll update. But, so far, so good! I did get the on Prime Days so price was more reasonable and used subscribe and save. The capsule isn’t enormous so easy to take, and there isn’t any type of taste when taking. ... show more
Reviewed in the United States on July 1, 2026 by Angie
    • At last, a formulation that really brings down Homocysteine levels
Size: 120 Count (Pack of 1)
At last, a formulation with all bioavailable forms of B vitamins with added TMG. Even the B6 is in the form of P-5-P, which is important for nerve health. However, I bought this to help bring down my Homocysteine, which was elevated even when taking other B Complex formulas. This really did what it says on the label as it brought my Homocysteine level back down to a healthy as shown by my blood tests. I will keep buying this as it works. ... show more
Reviewed in the United States on January 30, 2026 by Kindle Customer Chris
    • Homocysteine was requested by my Doctor. The order came in a timely fashion.
Size: 60 Count (Pack of 1)
Very good product, delivery was quick. The product was what was suggested by my Doctor.
Reviewed in the United States on February 3, 2026 by DOW STEEN
    • Life / Brain Changer
Size: 60 Count (Pack of 1)
I have tried 3 different products - I even tried “unmethylated” B12/folate etc. I do carry the MTHFR gene and have high homocysteine. THIS PRODUCT…. Not the others works for me. Though 2 caps is recommended and the dosage on the label is according to that - I can only do 1/4 of ONE capsule a day, but the difference in my life is night and day now. Im 67 and have lived most of my life with migraines, anxiety, depression and in the last couple of years I have been increasingly worried about my brain. My mother was diagnosed with Alzheimer’s at my age and I was mentally feeling worse and worse. I have recently come through a terrible tragedy - the violent death of my 40 year old son. After this happened I was significantly different in my brain. I could not shake the blackness (not just depression) I would wake in the morning and this horrible feeling was with me all day - consistently - over time. I put it down to grief. The first 3 days on this product I felt like I was 20 again. I remembered how I used to have hope and just feel “normal” like this. I realized quickly that I could not take 2 caps a day - I was literally flying mentally and did not sleep the first two nights. Over time I figured out my dosage and I am still in grief but I live every day ‘grounded’ and stable - I have energy and my brain fog is literally gone as is my black feeling in my brain. Anxiety and fear are just not there. I encourage everyone to at least get tested for the MTHFR gene and homocysteine - these tests are now available online without the need for a prescription (at least in California) - easy to find out! God bless you all - I am so thankful to the Lord for this answer to prayer. ... show more
Reviewed in the United States on May 6, 2026 by Wejoly
    • This really works!
Size: 120 Count (Pack of 1)
Fantastic product! My husband has had elevated homocysteine for several years. None of the other B complex vitamins he tried worked to lower it. His naturopathic doc recommended Homocysteine Supreme, and within 4 months taking 2 capsules daily his level went from 17 to 9. Highly recommend!
Reviewed in the United States on July 17, 2026 by J. Tucker
    • Functional medicine recommended
Size: 120 Count (Pack of 1)
Recommended by my functional medicine doctor, and it’s been great so far! Excellent quality and value, and I don’t notice any taste when taking it—which is a big plus.
Reviewed in the United States on October 18, 2025 by Tricia C.
    • Homocysteine Supreme
Size: 60 Count (Pack of 1)
Great Supplement recommended by my wellness physician.
Reviewed in the United States on July 6, 2026 by G. Jurney
    • No child lock
Size: 60 Count (Pack of 1)
Helps with anxiety! Good value for money. No child lock on bottle.
Reviewed in the United States on January 15, 2026 by Hope Kloepper

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