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Advantage

Advantage II Small Cat Vet-Recommended Flea Treatment & Prevention | Cats 5-9 lbs. | 2-Month Supply

  • Based on 37,396 reviews
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Size: 2 Pack


Features

  • Advantage II Small Cat is a leading brand in cat flea treatment and prevention for small cats 5-9 lbs., at least 8 weeks of age
  • Vet-recommended, easy-to-apply monthly topical treatment no hard-to-swallow pills, no prescription needed
  • Delivers total flea protection kills adult fleas, flea larvae and flea eggs through contact
  • Same-day effectiveness kills fleas within 12 hours of application and keeps working for 30 days
  • Fragrance-free formula, waterproof after 24 hours of application

Description

Advantage II Small Cat is a vet-recommended, leading brand in cat flea protection. Advantage II Small Cat flea treatment and prevention kills adult fleas, flea larvae and flea eggs to deliver total flea protection to your cat or kitten. Within 12 hours of application, Advantage II Small Cat topical treatment gets straight to work killing fleas through contact, so they don’t have to bite your cat to die. This treatment works hard for 30 days following application, effectively breaking the flea life cycle, controlling existing flea infestations and preventing further infestations all month long.Fleas not only cause discomfort; they can also pose other health risks. Monthly use of Advantage II Small Cat is important to protect your cat against fleas that may cause transmission of tapeworms, Flea Allergy Dermatitis and flea bite anemia.That’s why Advantage II Small Cat makes applying treatment simple. This convenient, spot-on application goes on the back of your cat’s neck at the base of the skull. You’ll simply place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. It goes on in seconds! It's easier than a flea collar and there are no hard- to-swallow pills. You’ll also love that Advantage II Small Cat is fragrance- free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects.Advantage II Small Cat flea protection is effective on both indoor and outdoor cats. Your cat should be at least 8 weeks old and weigh 5-9 lbs. to use Advantage II Small Cat.For the ultimate convenience in care, Advantage II Small Cat is available over the counter – no prescription needed. And, you can stock up with a subscription for regular doorstep deliveries so you never miss a monthly treatment. Advantage II Small Cat is a trademark of Elanco or its affiliates. Brand Story By Advantage

Brand: Advantage


Item Form: Topical


Scent: Unscented


Item Weight: 0.04 Pounds


Active Ingredients: Imidacloprid, Pyriproxyfen


Item Volume: 0.8 Milliliters


Allergen Information: Allergen-Free


Age Range (Description): 8 weeks and older


UPC:


Global Trade Identification Number: 37


Is Discontinued By Manufacturer ‏ : ‎ No


Product Dimensions ‏ : ‎ 1 x 4.38 x 4.75 inches; 0.64 ounces


Manufacturer recommended age ‏ : ‎ 1 month and up


Item model number ‏ : ‎ 86336650


Department ‏ : ‎ All Ages, Unisex


Date First Available ‏ : ‎ July 18, 2014


Manufacturer ‏ : ‎ Elanco US Inc


Best Sellers Rank: #364 in Pet Supplies (See Top 100 in Pet Supplies) #3 in Cat Flea Drops


#3 in Cat Flea Drops:


Brand Name: Advantage


Age Range Description: 8 weeks and older


UPC: 724089682437


Global Trade Identification Number: 37


Manufacturer Part Number: 86336650


Model Number: 86336650


Unit Count: 2 Count


Manufacturer: Elanco US Inc


Item Type Name: Topical


Item Form: Topical


Scent Name: Unscented


Target Species: Cat


Item Weight: 0.04 Pounds


Volume: 0.8 Milliliters


Allergen Information: Allergen-Free


Active Ingredients: Imidacloprid, Pyriproxyfen


Frequently asked questions

It's a topical treatment which is applied directly on your cat's skin, preferably at the base of the skull to prevent the cat from licking it off.

The product is designed for cats weighing between 5-9 lbs. It is not recommended for kittens under 8 weeks old. Always consult a vet if uncertain about its safety.

Each application provides a month's worth of protection against fleas. This pack provides a two-month supply.

No, Advantage II is specifically formulated to kill fleas at all life stages, but it does not offer protection against ticks.

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Top Amazon Reviews

🚀 Abunda's Overview

This is our summary and key points to consider based on customer reviews.

The reviews for Advantage II are generally positive, with most owners noting that it is effective in eliminating fleas on cats. The product seems to work quickly and has both immediate and long-term effects, according to most reviewers. Some buyers also learned the important efforts of regular vacuuming, washing, and month treatments for a flea-free environment. However, a few users reported that the treatment led to some fur loss, possibly due to a bad batch.

Pros

  • 🐾 Works effectually in eliminating fleas from cats
  • 👍 Provides immediate and long-term relief
  • 🎉 Especially beneficial for cats with severe flea reactions
  • 😺 Recommended by vets and loved by cats

Cons

  • 👎 Some users reported fur loss at the application spot
  • ❗ May have occasional bad batches or interactions
  • 🐱 Application might leave a wet spot on the cat's neck for a few hours

Should I Buy It?

If your cat is suffering from a flea infestation, Advantage II could be a beneficial purchase. Most of the reviews are positive highlighting its effectiveness against fleas. However, though rare, consider the potential for fur loss at the application spot.

    • IT'S AN UPHILL BATTLE!
Size: 4 Pack
All four of my cats have been inside cats from the start and yet got fleas! There have been no recent vet visits to blame either! Right from the start of treating my cats for their flea, the box of ADVANTAGE II, itself, presented a problem. It had a strange date, the ONLY date on it which I could find. Today is July 26, 2018), and on the box was V-03/2015. I was taken aback! The manufacture took place in March of 2015? Or was that an expiration date? WHAT did V-03/2015 MEAN? No explanation was found on the box nor in the instructions! I was concerned. I do not like being concerned about something which WILL enter my cats' blood stream! So I went to Bayer's site and discovered that all of us should not be concerned that there is no expiration date. OK. Then why in the past did this same brand have expiration dates on their boxes? So this is a "forever" poison which people could use on their cats in 2084? THAT is kind of scary if you think about it. You may be too young to remember DDT scares and the incomprehensible half-life of it. I was not able to get the two different weight recommended doses for two of my cats in the "small" category AND the doses for the two cats in the "large" category to begin treatment on the same day. And I wanted everything to start on the same day if possible AND when a vet would be on-call for any emergencies. And yes, emergencies happen with this flea killer according to some people. Advantage can take a few days to begin working once you begin treatment. Meanwhile, your animals are suffering. So I bought Capstar after a LOT of research which says Capstar gives relief within about six hours for cats and a shorter amount of time for dogs. Capstar is an oral, well, let's face it, insecticide. One can actually dose every twenty-four hours for at least a semi-permanent approach. But I don't see me getting a pill down four animals every single day for although easy at first, cats catch on quickly when you are coming at them with a pill, don't they? And eggs and larvae are NOT killed with this product. Remember that fighting fleas is an uphill battle of long-term treatment. BUT Capstar has filled in until our beginning the monthly treatments begin and within FOUR hours, our four cats were finally at PEACE with their bodies again. I do not exaggerate one bit! They were at peace with all they had gone through, within four hours! Again, I made sure a vet was on-call before application and during the wait-time of four to six hours. Before Capstar, there had been hair being pulled off (not out, exactly) by one, one running around crazy, one who developed an ultra sensitive back and could not stand to be patted or touched on his back anymore, and the fourth had begun gnawing his feet going in a pitiful way. Not one of the cats acted the SAME way toward the fleas and THAT threw my "diagnosis" of what in the world was going on. Was it the new snacks or a newly added brand to the multiple brands of wet cat food they eat? This misery occurred with our cats occurred within a week or two before I figured out it was FLEAS, not the change in food nor in our environment, causing stress. Our routine had changed due to husband's surgery and the installation of a somewhat noisy stair lift (probably a monster in their eyes, at least until they became used to it). I thought maybe all of that had stressed the cats or they were reflecting MY stress. After all, not two of the cats were behaving in the same way and I was homebound looking after my husband after his heart surgery and couldn't get FOUR cats to the vet by myself! Within four hours of EASY dosing with Capstar, my cats were again, themselves. Oh, my gosh! We had our cats back!!!! Those tiny pills and an index finger to the back of the mouth to a rolled over, sleepy cat were easy to administer. Just get them when they are asleep and roll them over before they know what is going on! All four seemed much relieved so quickly and, therefore, so was I. All of us piled in the bed last night with them not a one twitching, scratching or jerking around. PEACE at last! No fear for me getting bitten either! And Capstar instructions say that at that point, after about six hours max, there are no LIVE fleas at all on your pet. And it certainly seemed that way. It was a great night with them at last. My cats are indoor cats, completely. But ONE pregnant female flea, waiting on our doorstep or brought in by a worker, may have been the culprit which started this nightmare. This summer has been wet and warm. Fleas love that. Now, here's what I know from a similar infestation about seven years ago and from current research this time: VACUUM, VACUUM, VACUUM your floors and furniture for weeks! Vacuum every day and dispose of what you have vacuumed immediately. Eggs can live in your upholstery or carpets for months waiting for the right conditions to hatch many months after you thought you had everything under control! That is why treating with a monthly treatment FOR MONTHS and months will be necessary EVEN WITH INDOOR CATS. Only after about six or seven months last time did I stop the monthly treatments. I did NOT want to be putting poison on my cats' skins unnecessarily, but nor did I want the nasty flea critters back from OLD EGGS! I consider ourselves very luck to have had seven or more years flea-less! THAT is quite a victory! We live in a wildlife filled area. And flea types WILL change host species if they have to. That may have had something to do with the new fleas. Wash pet bedding (that means your spreads too!) very, very regularly. A substitute is putting something like a spread in the dryer every day or so for at least a week or so to kill the eggs AFTER you begin with the monthly treatment. There may be a few live fleas left somewher in your home and so you must be diligent. Look, this is a war! And with resistance to the insecticides used in these flea products apparently mounting, you have to look at this as if it is an emergency to get under control. And when you think you have it under control, do not stop with the vacuuming, the washing, and the monthly treatments for at least six months or so, I found. I think some people want the easy way out. Well, who doesn't, really? But getting rid of fleas cannot be approached in a "easy way out," amount of effort. This will take EFFORT and PERSISTENCE, in capital letters! Advantage II is a great product, but WE have to do our part too. Merely squeezing a liquid at the base of our cats' skulls is only a PART of the battle. Remember those eggs are laying in wait to hatch and begin the cycle all over again. Fleas cost SOOOOOOOOOOOOOOOOOOOO much misery for my cats! HUNDREDS of dollars will be spent by the time this war is over! Poison on my cats. ENDLESS work for me vacuuming and washing bedding and so on. And we are older and pretty darned infirm, but I am forced to vacuum and vacuum and vacuum ad infinitum! And we spend our retirement money and watch, most unfortunately, as our fur babies suffered. Get the CAPSTAR for IMMEDIATE relief for your cats (OR dogs!) and then get the Bayer Advantage II IN THE PROPER size for your kitty and begin the war which can be won! Capstar's instructions say it can be used with other flea treatments, but I am wary of that! You will have to hit this on all sides, especially at first! Just read, read, read all the instructions for safe usage of any of these products and be cautious upon application and for hours afterward. But boy am I pleased with the Capstar for the immediacy of its relief! Seeing our fur babies suffer is so sad for us. Unfortunately, it took me two weeks to figure out that it was FLEAS causing our cats' odd behaviors like jerking around, having very ultra sensitive backs, biting fur off (not actually out) , and excessive licking of feet. Each cat had it own timing for reacting to the fleas as one cat would react a certain way and another cat was reacting in a different way. Two cats started reactions a week before the other two finally succumbed to symptoms! And so, I thought there were different causes of their behaviors or their behaviors were reactions to the new stress in this home. Oh, if you cannot SEE the fleas on your cat but suspect them: dampen your hand with water and rub it lightly over the fur near where the tail starts. If you see tiny black specks, kind of like black pepper, those are minute bits are, well, flea excrement, from your cat being bitten. That is how I figured out what was going on! And while you are in "that" area, be on the look-out for tapeworms as are a different story. Fleas carry tapeworms! Just HOPE with all your might that you never see tiny, rice-like THINGS near your cats' under tail area! The fleas WILL lose this fight. I guarantee that! We are off to a good start with Capstar and Advantage II and the vacuuming of floors and upholstery and washing of bedding. We got by with seven years flea free for our ALWAYS indoor cats! And yet, here we go again! And I am a clean freak....so yes, it CAN happen in a very well kept, clean home! Keep at it. Take it seriously and work at it! It is a multi-pronged attck which will be needed but you have no choice! Two products: Capstar and Advantage II. One used first for IMMEDIATE relief (can dose every twenty-four hours for a while if necessary) and then the other for monthly applied treatments. I do NOT mix the products out of fear but read the Capstar info. The most important thing is that the products CANNOT do it all alone! You are going to have to work yourself bozo too! ... show more
Reviewed in the United States on July 26, 2018 by Amazon Customer
    • Works great in my multi-cat home!
Size: 4 Pack
Great buy, helps my 4 cat apartment stay flea free. I get it on autoship every month and they haven't had any fleas this spring! I think this is one of the best flea meds I've gotten them. I've tried Vectra, Pet Armor, and another two I can't remember the names of, but this one has been the best. I love the Revolution flea treatment but it's so expensive for 4 cats. This has saved us! ... show more
Reviewed in the United States on March 27, 2026 by Amanda Jones
    • Good flea prevention
Size: 2 Pack
This stuff does it job for my indoor/outdoor cat. We haven’t had any issues. Seems like a good value compared to other flea meds. There’s no smell and my cat doesn’t seem to have any reaction so we will continue purchasing.
Reviewed in the United States on February 4, 2026 by Twin_mama21
    • Flea’s Be Gone
Size: 2 Pack
Review Image by Cindy Roche
They use this product every three months on my dog and cat. It works pretty good. I find it doesn’t last quite three months, but it is the best flea medicine I have bought so far. It’s easy to apply and it does not bother my pets. I also like the price point.
Reviewed in the United States on February 22, 2026 by Cindy Roche
    • My cats were instantly purring with relief
Size: 4 Pack
We have 4 cats. Our home is all hard floors, 3 of our cats go outside occasionally. This winter, I found fleas on ME 3 seperate times. I was like no, absolutely not. I bought flead bombs, I gave them all flea baths and gave them a couple days before the flea meds from actispot (more budget friendly). But no... Still fleas. I applied this 3 weeks later.. My cats within an hour were jumping on me, purring, happy again. They have not been itching any more. They are back to their sweet selves and I dont have fleas anymore ... show more
Reviewed in the United States on January 30, 2026 by Sara
    • Small size minimizes negative reactions
Size: 2 Pack
I have 2 cats. One is noticeably overweight (Luna) while the other (Momma) is normal cat weight. Since they're both adults, I used the 'large' cat flea treatment on both of them last time. Momma had such a negative reaction, whereas Luna had no reaction. Lesson learned. This time I ordered a box of the 'small' cat treatment for Momma. She's probably at the high-end weight (9 - 10 lbs) for the treatment, but I felt a million times better putting this on her and she didn't react nearly as much. I should mention she's a wild cat living indoors so putting it on her has to be a 1-hand job. It's tough - so separating the fur like they tell you to in the instructions is impossible with her. I simply give her a treat in one hand and with the other hand, I press the flea meds at the base of her neck and quickly squeeze. Somehow it works. After a few days almost all scratching stops (they still scratch a little but that might just be bites healing). There's no color or smell to this stuff and speed-wise, it starts working right away. These flea treatments always make me nervous, but the pros really outweigh the cons and my cats are noticeably more comfortable not scratching. ... show more
Reviewed in the United States on November 20, 2024 by A. Mitchell
    • Functional in most cases.
Size: 2 Pack
This used to work for our cats, but for some reason stopped doing so. We switched to a more expensive but functional option. If you're dealing with a new cat, I would say give it a try. It may be enough. Monitor the fur baby and if it doesn't seem to work after 2 applications talk to the vet for additional choices. ... show more
Reviewed in the United States on November 2, 2025 by Cat
    • Fleas and eggs GONE
Size: 4 Pack
My daughter has 3 cats. We been dealing with the fleas for about 3 months. We tried other products and vacuumed everyday and instead they got worse. We were infested. They had so many fleas and eggs. I was so overwhelmed and desperate cause I just couldn’t stand seeing the babies scratching do much. I decided to advantage II a try and omg by next day the babies were more relaxed and when I combed them I don’t know what happen to the eggs and fleas!!! They were gone! I recommend this product ... show more
Reviewed in the United States on March 14, 2026 by aida

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