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Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 1-Month Supply

  • Based on 74,895 reviews
Condition: New
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Availability: In Stock.
Fulfilled by Amazon

Arrives Thursday, Jul 17
Order within 17 hours and 14 minutes
Available payment plans shown during checkout

Size: 1-Pack


Style: Large Cat only


Features

  • Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
  • Vet-recommended, easy-to-apply monthly topical treatment no hard-to-swallow pills, no prescription needed
  • Delivers total flea protection kills adult fleas, flea larvae and flea eggs through contact
  • Same-day effectiveness kills fleas within 12 hours of application and keeps working for 30 days
  • Fragrance-free formula, waterproof after 24 hours of application

Description

Advantage II Large Cat is a vet-recommended, leading brand in cat flea protection. Advantage II Large Cat flea treatment and prevention kills adult fleas, flea larvae and flea eggs to deliver total flea protection to your cat or kitten. Within 12 hours of application, Advantage II Large Cat topical treatment gets straight to work killing fleas through contact, so they dont have to bite your cat to die. This treatment works hard for 30 days following application, effectively breaking the flea life cycle, controlling existing flea infestations and preventing further infestations all month long. Fleas not only cause discomfort; they can also pose other health risks. Monthly use of Advantage II Large Cat is important to protect your cat against fleas that may cause transmission of tapeworms, Flea Allergy Dermatitis and flea bite anemia. That’s why Advantage II Large Cat makes applying treatment simple. This convenient, spot-on application goes on the back of your cat’s neck at the base of the skull. You’ll simply place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. It goes on in seconds! It's easier than a flea collar and there are no hard-to-swallow pills. You’ll also love that Advantage II Large Cat is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects. Advantage II Large Cat flea protection is effective on both indoor and outdoor cats. Your cat should be at least 8 weeks old and weigh over 9 lbs. to use Advantage II Large Cat. For the ultimate convenience in care, Advantage II Large Cat is available over the counter – no prescription needed. And, you can stock up with a subscription for regular doorstep deliveries so you never miss a monthly treatment. Advantage II Large Cat is a trademark of Elanco or its affiliates.

Brand: Advantage


Item Form: Topical


Scent: Unscented


Active Ingredients: Imidacloprid, Pyriproxyfen


Item Volume: 0.8 Milliliters


Allergen Information: Allergen-Free


Age Range (Description): 8 weeks and older


UPC:


Global Trade Identification Number: 69


Product Dimensions ‏ : ‎ 4.25 x 0.87 x 4.72 inches; 0.63 ounces


Item model number ‏ : ‎ 90204382


Date First Available ‏ : ‎ March 27, 2019


Manufacturer ‏ : ‎ Elanco US Inc


Country of Origin ‏ : ‎ Germany


Best Sellers Rank: #57 in Pet Supplies (See Top 100 in Pet Supplies) #1 in Cat Flea Drops


#1 in Cat Flea Drops:


Customer Reviews: 4.5 4.5 out of 5 stars 74,895 ratings


Item Weight: 0.634 ounces


Manufacturer: Elanco US Inc


Country of Origin: Germany


Item model number: 90204382


Date First Available: March 27, 2019


Item Package Dimensions L x W x H: 4.74 x 4.33 x 0.94 inches


Item Dimensions LxWxH: 4.25 x 0.87 x 4.72 inches


Brand Name: Advantage


Target Audience Keyword: house-cats, cats


Directions: Application Instructions 1. Use only on cats. 2. Hold applicator tube in an upright position. Pull cap off tube. 3. Turn the cap around and place other end of cap back on tube. Twist cap to break seal, then remove cap from tube. 4. Part the hair at the base of the cat’s skull until skin is visible. 5. Evenly apply the entire contents of the Advantage II tube directly on the skin by squeezing the entirety of the contents in that one spot. Do not get this product in your cat’s eyes, or allow your cat to ingest this product.


Model Name: Advantage II


Color: Large Cat only


Size: 1-Pack


Age Range Description: 8 weeks and older


Number of Items: 1


Style: Large Cat only


Breed Recommendation: Large


Specific Uses for Product: Parasites


Frequently asked questions

If you place your order now, the estimated arrival date for this product is: Thursday, Jul 17

Yes, absolutely! You may return this product for a full refund within 30 days of receiving it.

To initiate a return, please visit our Returns Center.

View our full returns policy here.

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Top Amazon Reviews


  • Excellent product and worth every penny!
Size: 6-Pack Style: Large Cat only
I won't mention names. But, don't waste your time buying cheaper products, especially if your cats actively have fleas. I used a different product for several years. Evidently, my cats became immune to it. I ended up with a full on flea infestation in my home. It was located primarily in my hallway, master bedroom, and my bed. I purchased food grade DE powder. I followed the instructions. It worked well. Unfortunately, I have MCAS and the DE powder caused a severe reaction. I don't recommend that process to anyone. I purchased a different brand of flea & tick medication. I had to dose my 7 cats twice. It did not work completely. I put this flea and tick medicine on my cats two days ago. They come in nice little tubes. It's easy to apply. Each dose is individually packages. No scissors needs to open these large bulky contraptions with very little medication in them. I've deflead my home. This problem is just about resolve now. I highly recommend and will continue purchasing this brand only! Thank you! ... show more
Reviewed in the United States on June 19, 2025 by Sophia David

  • Advantage II Large Cat Flea Treatment: Effective and Hassle-Free Protection!
Size: 4-Pack Style: Large Cat only
The Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention (4-Month Supply, Cats Over 9 lbs.) has been a game-changer for my indoor-outdoor cat. This topical solution, backed by veterinarians, is super easy to apply—just a quick squeeze at the base of the skull, no pills required. The fragrance-free formula kills fleas, larvae, and eggs on contact within 12 hours, preventing bites and breaking the flea life cycle for a full 30 days per dose. My cat’s scratching stopped almost immediately, and I’ve noticed no fleas since starting the treatment. The 4-month supply is convenient and cost-effective, with no prescription needed, and the waterproof formula holds up after 24 hours, perfect for my cat who loves exploring. The active ingredients, imidacloprid and pyriproxyfen, work effectively without needing fleas to bite, reducing risks like tapeworm or dermatitis. Application is straightforward, though I ensure my cat doesn’t lick the spot initially to avoid mild salivation. While some users report rare skin irritation, my cat had no issues, but I’d suggest monitoring after the first use and consulting a vet for sensitive pets. For anyone with a cat over 9 lbs. needing reliable flea control, this is a solid, vet-trusted choice that delivers peace of mind and a happy, itch-free pet! Consult a veterinarian before use. ... show more
Reviewed in the United States on May 30, 2025 by Martin E.

  • Super easy, dries faster than other brands.
Size: 6-Pack Style: Large Cat only
Of all the flea and tick meds out there, this is by far the easiest to apply and the fastest to dry. I live on the east coast with all kinds of ticks in abundance. Just yesterday before applying, I had pulled three different kind of ticks off my one cat. Let's see if the solution is as powerful as other brands. I will post an update in a week or so. ... show more
Reviewed in the United States on June 11, 2025 by danielle moir

  • Works pretty good but doesn’t last a full month
Size: 6-Pack Style: Large Cat only
This works well enough if you don’t have active fleas in your yard or house but I usually have to reapply after three weeks during the warmer seasons. I use it for my cats because it’s one of the milder preventables and none of them have any problems tolerating it. It takes several hours to dry and a couple of my cats get a little bit of flakiness where I applied it that is temporary. It starts working fairly fast, within a few hours usually. One warning though, make sure you follow the directions of how and where to put it on so your cat doesn’t have access to lick it off. ... show more
Reviewed in the United States on June 5, 2025 by Janice

  • Effective and safe
Size: 4-Pack Style: Large Cat only
Reliable control of fleas for your cat(s). Might be old school product, but gets the job done. Have 2 cats (lighter weight cats) and ordering the product for large (higher weight) cats was able to save $$ by splitting a tube between cats. Ease of application and effective flea control. Put product on my cat as directed between shoulder blades and saw results quickly within hours of application. ... show more
Reviewed in the United States on June 5, 2025 by Amazon Customer

  • BEST flea medicine out there for cats!!! A+
Size: 2-Pack Style: Large Cat only
This brand is consistently RELIABLE! The only flea medicine I trust to use on my cats! Kills fleas and leaves them comfortable! Been using this product for years and 5 stars all the way!!! A++++ ⭐️⭐️⭐️⭐️⭐️
Reviewed in the United States on June 14, 2025 by Holly Turkovich

  • Highly recommend
Size: 1-Pack Style: Large Cat only
I have to say this worked within 2days after putting the application. After that no sign of scratching or anything! Highly recommended!! It helped!!
Reviewed in the United States on June 13, 2025 by Jasmin

  • Unsatisfied
Size: 6-Pack Style: Large Cat only
Well, I'm unsatisfied overall. I have been using this flea and tick medicine for 4 months now and I have been pulling ticks off my cat. And just to be super specific i just reapplied meds to him a week ago and pulled two ticks off him today. Now, I have to say it's only around his eyes or crawling on his fur but I constantly have to check him. Unfortunately, for the price I was hoping for better results. Moving forward with another bread. ... show more
Reviewed in the United States on May 21, 2025 by Alayna

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