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Advantage

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 1-Month Supply

  • Based on 6,966 reviews
Condition: New
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Availability: In Stock.
Fulfilled by Amazon
Arrives Wednesday, Sep 9
Order within 21 hours and 42 minutes
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Size: 1-Pack


Features

  • Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
  • Vet-recommended, easy-to-apply monthly topical treatment no hard-to-swallow pills, no prescription needed
  • Delivers total flea protection kills adult fleas, flea larvae and flea eggs through contact
  • Same-day effectiveness kills fleas within 12 hours of application and keeps working for 30 days
  • Fragrance-free formula, waterproof after 24 hours of application

Description

Advantage II Large Cat is a vet-recommended, leading brand in cat flea protection. Advantage II Large Cat flea treatment and prevention kills adult fleas, flea larvae and flea eggs to deliver total flea protection to your cat or kitten. Within 12 hours of application, Advantage II Large Cat topical treatment gets straight to work killing fleas through contact, so they dont have to bite your cat to die. This treatment works hard for 30 days following application, effectively breaking the flea life cycle, controlling existing flea infestations and preventing further infestations all month long. Fleas not only cause discomfort; they can also pose other health risks. Monthly use of Advantage II Large Cat is important to protect your cat against fleas that may cause transmission of tapeworms, Flea Allergy Dermatitis and flea bite anemia. That’s why Advantage II Large Cat makes applying treatment simple. This convenient, spot-on application goes on the back of your cat’s neck at the base of the skull. You’ll simply place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. It goes on in seconds! It's easier than a flea collar and there are no hard-to-swallow pills. You’ll also love that Advantage II Large Cat is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects. Advantage II Large Cat flea protection is effective on both indoor and outdoor cats. Your cat should be at least 8 weeks old and weigh over 9 lbs. to use Advantage II Large Cat. For the ultimate convenience in care, Advantage II Large Cat is available over the counter – no prescription needed. And, you can stock up with a subscription for regular doorstep deliveries so you never miss a monthly treatment. Advantage II Large Cat is a trademark of Elanco or its affiliates.

Brand: Advantage


Item Form: Topical


Scent: Unscented


Item Weight: 18.14 g


Active Ingredients: Imidacloprid, Pyriproxyfen


Item Volume: 0.8 ml


Allergen Information: Allergen-Free


Unit Count: 1 Count


Age Range (Description): 8 weeks and older


UPC:


Product Dimensions ‏ : ‎ 4.25 x 0.87 x 4.72 inches; 0.69 ounces


Item model number ‏ : ‎ 90204382


Date First Available ‏ : ‎ March 27, 2019


Manufacturer ‏ : ‎ Elanco US Inc


Best Sellers Rank: #1,651 in Pet Supplies (See Top 100 in Pet Supplies) #16 in Cat Flea Drops


#16 in Cat Flea Drops:


Customer Reviews: 4.4 4.4 out of 5 stars (6,966)


Brand Name: Advantage


Unit Count: 1 Count


Age Range Description: 8 weeks and older


UPC: 724089114969


Global Trade Identification Number: 69


Item Type Name: Topical


Manufacturer: Elanco US Inc


Model Number: 90204382


Manufacturer Part Number: 90204382


Item Form: Topical


Scent Name: Unscented


Target Species: Cat


Item Weight: 18.14 g


Volume: 0.8 ml


Allergen Information: Allergen-Free


Active Ingredients: Imidacloprid, Pyriproxyfen


Frequently asked questions

If you place your order now, the estimated arrival date for this product is: Wednesday, Sep 9

Yes, absolutely! You may return this product for a full refund within 30 days of receiving it.

To initiate a return, please visit our Returns Center.

View our full returns policy here.

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Similar Products

Top Amazon Reviews

    • IT WORKS! 24 hours after application and NO LIVE FLEAS.
Size: 1-Pack
Review Image by Verified Amazon Customer
Review Image by Verified Amazon Customer
Review Image by Verified Amazon Customer
Review Image by Verified Amazon Customer
I like to know things. One question I had was how in the *#*@ does an indoor cat get fleas? I looked it up and it's a lot more common that one might think. Fleas are jumpy little things that find their way onto shoes, clothing, and other things people bring home with them. Unless one never leaves their house, there's a very good chance of bringing fleas in with you without ever knowing. Long story short, once I noticed the fleas, I took steps to get it under control. A flea comb is essential! My vet recommended a topical, so I spent the big money and went with a FRONT of the LINE solution. It was supposed to be the best in the biz. I followed the directions and it did absolutely **nothing** for my cat. I was still combing live fleas out of her by the hundreds. It was a total waste of money. A week later I applied another dose of the FRONT of the LINE topical. Again, it did absolutely **nothing** for her. After which, I tried a flea spray to no advantage. She hated it, it smelled terrible, and because she hated it, I couldn't get it far enough into her long fur for it to do any good. We ended up using the spray on our furniture and her carpets. We did NOT want to put her in the bathtub. I mean, if you've ever bathed a cat in less than a full suit of armor, you know what I'm talking about. I purchased a dry flea & tick shampoo along with the same brand of spray. The waterless flea bath "does" kill fleas after a few seconds in the foam, but she hated it so much her behavior changed drastically. Drastically enough that it scared the crap out of me. She stopped coming in the living room, stopped perching on the back of my chair, wouldn't jump on me for cuddles, was lethargic, and stopped sleeping on my chest after I went to bed. She wasn't acting like herself. At. All. That said, I was still combing live fleas out by the dozens. That number would have been a lot higher but since she was already not acting like herself, I didn't want to stress her out even more by doing more combing. Enter Advantage II Large Cat. I always do a lot of research before using a new product. I had seen the nightmare reviews of skin burns and worse. Even so, there were a lot more good reviews than bad...and I was getting desperate. Using the Advantge II Large Cat was my 2nd to last resort. IF it didn't work, she was going to get a water bath...and I don't have a suit of armor. I was looking as forward to doing that as I would look forward to dragging my body over razor wire...which is essentially the same thing. I am very happy, thrilled in fact, to report that this product worked beautifully! I properly applied the product on 10/29/25 at 3pm. I was very careful to make sure I parted her long fur enough for it to get on her skin. The product takes a full 12 hours to reach is max potency. After 12 hours, I was coming less live fleas from her. It is now 10/31/25 and at last combing, there were NO live fleas. Zero. Ziltch. Nada. Her behavior is returning to normal, she's not scratching/biting like a little banshee anymore, and she had no adverse reactions to the product. I will continue to be diligent with the flea comb to see if she needs another treatment next week. Knowing what I know now, I wish I wouldn't have wasted my money on the FRONT of the LINE solution and used Advantage II Large Cat from the get go. I could have saved my cat and myself a lot of undo stress and worry. I highly recommend this product. Note: If one is worried about their cat's skin, I recommend using one or two drops to "test" how your cat will react to it before giving the full dose. ... show more
Reviewed in the United States on October 31, 2025 by Verified Amazon Customer
    • Fast relief for stressed out cats and tired owners.
Size: 1-Pack
TL;DR: Works quickly, easy to use, and stopped a full flea flare up in a day without turning it into a huge chore. We grabbed this during a sudden little outbreak, and I was honestly relieved at how simple it was to use. The tube opens cleanly without splattering, and the liquid goes right onto the skin without any fighting or trying to part the fur forever. Our big cat barely reacted, which made the whole thing easier. What stood out most, though, was how fast it worked. By the next day, the scratching had almost completely stopped, and the fleas we saw earlier were gone. There’s something comforting about using a product that doesn’t need tricks or follow up treatments right away. It just gets in there, does the job, and lets the whole house calm down again. I also appreciate that it’s unscented. No strong chemical smell lingering on the cat or in the room. As the days went on, the difference stayed steady. No more tiny specks showing up, no more frantic grooming, and the cat settled right back into normal behavior. It didn’t irritate his skin or leave any oily patch that lingered forever, which sometimes happens with other treatments. This one soaked in cleanly and didn’t bother him at all. Having something that clears things up fast is a huge help when you’re juggling pets, kids, and everything else. It feels like a reliable tool you keep on hand just in case, and it’s reassuring knowing you’re using something vet recommended with ingredients that have been around for years. There’s a good sense of trust that comes with that. What I like most is the peace of mind afterward. Once it kicked in, the whole flea situation was just done, and that kind of quick resolution is worth a lot. It’s the kind of product you’re grateful to have on hand before a problem turns into a bigger headache. Tip: Apply it when your cat is relaxed and already settled so the dose goes on smoothly without any twisting or fussing. Don't let them flick their head and splash it in your eyes! Hope this helps! =) ... show more
Reviewed in the United States on December 7, 2025 by Thraddash
    • Buy it! It works phenomenally per my 4 cats!!
Size: 1-Pack
I can’t believe I used to take my cats to the vet and pay so much $$ when I could have been using this the whole time! It works phenomenally. I have four cats, and when we had an outbreak of fleas, I started researching affordable options not a vet. There were so many good reviews about Advantage II and I was desperate. I ordered the four pack. It worked absolutely wonderfully! Highly recommend this versus spending tons of money at the Vet! Also, when a friend had an outbreak of fleas, I ordered one pack for her to be delivered same day. I got it within two hours of my order! That to me is worth every penny! Thank you Amazon you really came through on this one! ... show more
Reviewed in the United States on June 29, 2026 by S&D
    • San Diego fleas are developing immunity
Size: 1-Pack
I've used Advantage on my cats for 20 years. It worked perfectly until this year. I live on the coast in San Diego. Several veterinarians have told me that the fleas in this area have developed a high tolerance to it, making it a bit less effective than before. As a result I've had to switch to prescription flea meds. I've not heard of this being a problem in other places throughout the U.S. it's worth asking people in your area, to find out what works the best. ... show more
Reviewed in the United States on August 7, 2025 by Flametop Guitars
    • Best Flea Medication 🐈
Size: 1-Pack
My "Handsome" had a really bad season with fleas, within 48 hours of applying the product I stopped seeing fleas on him. He was beginning to itch really bad because of the fleas biting him, but after applying the product he stopped itching and his skin started to heal 💖 Definitely worth the money and don't suggest waiting. ... show more
Reviewed in the United States on June 5, 2026 by Cheyenne Jimenez
    • I’m thinking fleas are immune to
Size: 1-Pack
Does seem to work
Reviewed in the United States on June 5, 2026 by Eileen Turner
    • Lily
Size: 1-Pack
Review Image by Rixin chen
Effective dewormer, easy to feed, no side effects.
Reviewed in the United States on June 25, 2026 by Rixin chen
    • Loss of fur and still has fleas!!!
Size: 1-Pack
Review Image by Mary C.
I do not recommend this product Did not get rid of fleas!!! and now my cat is losing hair on the inside of his back legs and his belly. Going to take him to the vet.
Reviewed in the United States on July 6, 2026 by Mary C.

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