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Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 4-Month Supply

Based on 74,895 reviews
Condition: New
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$51.98
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Availability: Only 7 left in stock, order soon!
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Arrives Friday, Oct 30
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At a glance

Condition
New
Size
4-Pack
Dimensions
6.5 x 1 x 4.25 in; 0.8 oz
Weight
0.05 lb
Color
Large Cat only
Material
Plastic
Item Form
Topical

Features 5

  • Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
  • Vet-recommended, easy-to-apply monthly topical treatment no hard-to-swallow pills, no prescription needed
  • Delivers total flea protection kills adult fleas, flea larvae and flea eggs through contact
  • Same-day effectiveness kills fleas within 12 hours of application and keeps working for 30 days

Description

Advantage II Large Cat is a vet-recommended, leading brand in cat flea protection. Advantage II Large Cat flea treatment and prevention kills adult fleas, flea larvae and flea eggs to deliver total flea protection to your cat or kitten. Within 12 hours of application, Advantage II Large Cat topical treatment gets straight to work killing fleas through contact, so they don’t have to bite your cat to die. This treatment works hard for 30 days following application, effectively breaking the flea life cycle, controlling existing flea infestations and preventing further infestations all month long.Fleas not only cause discomfort; they can also pose other health risks. Monthly use of Advantage II Large Cat is important to protect your cat against fleas that may cause transmission of tapeworms, Flea Allergy Dermatitis and flea bite anemia.That’s why Advantage II Large Cat makes applying treatment simple. This convenient, spot-on application goes on the back of your cat’s neck at the base of the skull. You’ll simply place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. It goes on in seconds! It's easier than a flea collar and there are no hard- to-swallow pills. You’ll also love that Advantage II Large Cat is fragrance- free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects.Advantage II Large Cat flea protection is effective on both indoor and outdoor cats. Your cat should be at least 8 weeks old and weigh over 9 lbs. to use Advantage II Large Cat.For the ultimate convenience in care, Advantage II Large Cat is available over the counter – no prescription needed. And, you can stock up with a subscription for regular doorstep deliveries so you never miss a monthly treatment. Advantage II Large Cat is a trademark of Elanco or its affiliates. Biting fleas are more than just a nuisance for your cat. Left unchecked, they can cause serious disorders such as flea allergy dermatitis, secondary skin infections, tapeworms, and even anemia. This topical flea treatment stops fleas before they become a problem. Providing a full month of protection, it begins working in minutes, killing 98-100% of the fleas on cats within 12 hours, and 99% of flea larvae within 20 minutes. Plus, since dead fleas can't lay eggs and dead larvae can't hatch, the flea's life cycle is halted. Any new fleas your cat encounters are killed within two hours-- preventing re-infestation for as long as four weeks. In fact, Advantage does such a good job breaking the flea's life cycle, there's no need to treat your cat's environment. Applied before the start of flea season, it helps keep your cat from becoming infested in the first place. Used year-round, it prevents fleas from over-wintering in your home to feast on your cat the next season. Safe for kittens as young as eight weeks and as small as nine pounds, Advantage is also water-resistant. This package includes 4 pre-measured doses in easy-to-use applicator tubes. Warnings Hazards to Humans: Causes eye irritation. Harmful if swallowed. Do not get in eyes or on clothing. Avoid contact with skin. Wash hands thoroughly with soap and warm water after handling. Keep out of reach of children. Do not contaminate feed or food. Hazards to Domestic Animals: For external use only. Do not use on kittens under eight weeks of age. As with any product, consult your veterinarian before using this product on debilitated, aged, pregnant or nursing animals. Individual sensitivities, while rare, may occur after using ANY pesticide product for pets. If signs persist, or become more severe, consult a veterinarian immediately. If your animal is on medication, consult your veterinarian before using this or any other product. For consumer questions call . For medical emergencies call . First Aid: If in eyes: Hold eyelids open and flush with plenty of water. Get medical attention if irritation persists. If swallowed: Call a physician or Poison Control Center. If on skin: Wash with plenty of soap and water.

Specs 30

Brand Advantage
Item Form Topical
Scent Unscented
Item Weight 0.05 Pounds
Active Ingredients Imidacloprid, Pyriproxyfen
Item Volume 3.2 Milliliters
Allergen Information Allergen-Free
Dog Breed Size Large

Frequently asked questions

If you place your order now, the estimated arrival date for this product is: Friday, Oct 30

Yes, absolutely! You may return this product for a full refund within 30 days of receiving it.

To initiate a return, please visit our Returns Center.

View our full returns policy here.

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Top Amazon Reviews


Fast relief for stressed out cats and tired owners.
Size: 1-Pack
TL;DR: Works quickly, easy to use, and stopped a full flea flare up in a day without turning it into a huge chore. We grabbed this during a sudden little outbreak, and I was honestly relieved at how simple it was to use. The tube opens cleanly without splattering, and the liquid goes right onto the skin without any fighting or trying to part the fur forever. Our big cat barely reacted, which made the whole thing easier. What stood out most, though, was how fast it worked. By the next day, the scratching had almost completely stopped, and the fleas we saw earlier were gone. There’s something comforting about using a product that doesn’t need tricks or follow up treatments right away. It just gets in there, does the job, and lets the whole house calm down again. I also appreciate that it’s unscented. No strong chemical smell lingering on the cat or in the room. As the days went on, the difference stayed steady. No more tiny specks showing up, no more frantic grooming, and the cat settled right back into normal behavior. It didn’t irritate his skin or leave any oily patch that lingered forever, which sometimes happens with other treatments. This one soaked in cleanly and didn’t bother him at all. Having something that clears things up fast is a huge help when you’re juggling pets, kids, and everything else. It feels like a reliable tool you keep on hand just in case, and it’s reassuring knowing you’re using something vet recommended with ingredients that have been around for years. There’s a good sense of trust that comes with that. What I like most is the peace of mind afterward. Once it kicked in, the whole flea situation was just done, and that kind of quick resolution is worth a lot. It’s the kind of product you’re grateful to have on hand before a problem turns into a bigger headache. Tip: Apply it when your cat is relaxed and already settled so the dose goes on smoothly without any twisting or fussing. Don't let them flick their head and splash it in your eyes! Hope this helps! =) ... show more
Reviewed in the United States on December 7, 2025 by Thraddash

IT WORKS! 24 hours after application and NO LIVE FLEAS.
Size: 1-Pack
I like to know things. One question I had was how in the *#*@ does an indoor cat get fleas? I looked it up and it's a lot more common that one might think. Fleas are jumpy little things that find their way onto shoes, clothing, and other things people bring home with them. Unless one never leaves their house, there's a very good chance of bringing fleas in with you without ever knowing. Long story short, once I noticed the fleas, I took steps to get it under control. A flea comb is essential! My vet recommended a topical, so I spent the big money and went with a FRONT of the LINE solution. It was supposed to be the best in the biz. I followed the directions and it did absolutely **nothing** for my cat. I was still combing live fleas out of her by the hundreds. It was a total waste of money. A week later I applied another dose of the FRONT of the LINE topical. Again, it did absolutely **nothing** for her. After which, I tried a flea spray to no advantage. She hated it, it smelled terrible, and because she hated it, I couldn't get it far enough into her long fur for it to do any good. We ended up using the spray on our furniture and her carpets. We did NOT want to put her in the bathtub. I mean, if you've ever bathed a cat in less than a full suit of armor, you know what I'm talking about. I purchased a dry flea & tick shampoo along with the same brand of spray. The waterless flea bath "does" kill fleas after a few seconds in the foam, but she hated it so much her behavior changed drastically. Drastically enough that it scared the crap out of me. She stopped coming in the living room, stopped perching on the back of my chair, wouldn't jump on me for cuddles, was lethargic, and stopped sleeping on my chest after I went to bed. She wasn't acting like herself. At. All. That said, I was still combing live fleas out by the dozens. That number would have been a lot higher but since she was already not acting like herself, I didn't want to stress her out even more by doing more combing. Enter Advantage II Large Cat. I always do a lot of research before using a new product. I had seen the nightmare reviews of skin burns and worse. Even so, there were a lot more good reviews than bad...and I was getting desperate. Using the Advantge II Large Cat was my 2nd to last resort. IF it didn't work, she was going to get a water bath...and I don't have a suit of armor. I was looking as forward to doing that as I would look forward to dragging my body over razor wire...which is essentially the same thing. I am very happy, thrilled in fact, to report that this product worked beautifully! I properly applied the product on 10/29/25 at 3pm. I was very careful to make sure I parted her long fur enough for it to get on her skin. The product takes a full 12 hours to reach is max potency. After 12 hours, I was coming less live fleas from her. It is now 10/31/25 and at last combing, there were NO live fleas. Zero. Ziltch. Nada. Her behavior is returning to normal, she's not scratching/biting like a little banshee anymore, and she had no adverse reactions to the product. I will continue to be diligent with the flea comb to see if she needs another treatment next week. Knowing what I know now, I wish I wouldn't have wasted my money on the FRONT of the LINE solution and used Advantage II Large Cat from the get go. I could have saved my cat and myself a lot of undo stress and worry. I highly recommend this product. Note: If one is worried about their cat's skin, I recommend using one or two drops to "test" how your cat will react to it before giving the full dose. ... show more
Reviewed in the United States on October 31, 2025 by Verified Amazon Customer Verified Amazon Customer

Reliable Flea Protection That Works Quickly
Size: 4-Pack
I’ve been using Advantage II for my large cat (over 12 lbs), and it’s the only flea treatment I fully trust. Within just a day of applying it, I noticed a big difference—scratching stopped, and I wasn’t finding fleas on her bedding anymore. By the second day, the fleas were completely gone. Application is simple: just part the fur at the base of the neck and apply directly to the skin. My cat tolerates it well, and the formula dries quickly without leaving a greasy mess. I also appreciate that it’s waterproof after 24 hours, so I don’t have to worry if she gets into a little rain or needs a bath. The 4-month supply is cost-effective compared to buying single doses, and I like knowing I can stay ahead of any infestations. This product really delivers on prevention as well—no fleas have come back in between monthly doses. If you have a bigger cat and need something safe, effective, and vet-recommended, this is an excellent choice. It gives peace of mind and keeps both your cat and your home flea-free. Highly recommend! ... show more
Reviewed in the United States on August 22, 2025 by tara speece
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