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Advantage

Advantage II XL Dog Vet-Recommended Flea Treatment & Prevention | Dogs Over 55 lbs. | 6-Month Supply

  • Based on 6,539 reviews
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Availability: In Stock.
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Arrives Sunday, Jun 22
Order within 7 hours and 56 minutes
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Size: 6-Pack


Style: XL Dog only


Features

  • Vet recommended flea treatment and prevention for dogs at weighing over 55 lbs., at least 7 weeks of age
  • Kills adult fleas, flea larvae and flea eggs for total flea prevention and treatment
  • Same-day effectiveness, kills fleas within 12 hours of application and keeps working for 30 days
  • Easy-to-apply topical treatment, no prescription needed
  • Fragrance-free formula, waterproof after 24 hours

Description

Advantage II Extra Large Dog is the vet-recommended prevention and treatment of flea and lice infestations in dogs. Advantage II Extra Large Dog flea treatment and prevention kills adult fleas, flea larvae and flea eggs to deliver total flea protection to your dog or puppy. In fact, within 12 hours of application, Advantage II Extra Large Dog topical treatment gets straight to work killing fleas through contact, so they don’t have to bite your dog to die.This 30-day treatment effectively breaks the flea life cycle, controlling existing flea and lice infestations and preventing further infestations all month long. Fleas not only cause discomfort; they can also pose other health risks. Monthly use of Advantage II Extra Large Dog is important to protect your dog against fleas that may cause transmission of tapeworms in dogs, Flea Allergy Dermatitis and flea bite anemia.That’s why Advantage II topical, spot- on formula makes application simple - going on in seconds. It's easier than a flea collar and there are no hard-to-swallow pills. You’ll also love that Advantage II is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects. Advantage II Extra Large Dog flea and lice protection is effective on both indoor and outdoor dogs. Your dog should be at least 7 weeks old and weigh over 55 lbs. to use Advantage II Extra Large Dog.For the ultimate convenience in care, Advantage II Extra Large Dog is available over the counter – no prescription needed. And, you can stock up with a subscription for regular doorstep deliveries so you never miss a monthly treatment. Once Advantage II Extra Large Dog is applied, your dog is ready to get right back to exploring his favorite places – from the backyard to the dog park.Advantage II Extra Large Dog is a trademark of Elanco or its affiliates.

Brand: Advantage


Item Form: Topical


Scent: Unscented


Item Weight: 0.16 Pounds


Active Ingredients: Imidacloprid, Pyriproxyfen


Item Volume: 24 Milliliters


Allergen Information: Allergen-Free


Dog Breed Size: Large


Age Range (Description): 7 weeks and older


UPC:


Is Discontinued By Manufacturer ‏ : ‎ No


Product Dimensions ‏ : ‎ 1.38 x 4.38 x 6.63 inches; 2.56 ounces


Item model number ‏ : ‎ 86336669


Department ‏ : ‎ Flea & Tick


Date First Available ‏ : ‎ March 5, 2011


Manufacturer ‏ : ‎ Elanco US Inc


Country of Origin ‏ : ‎ Germany


Best Sellers Rank: #5,144 in Pet Supplies (See Top 100 in Pet Supplies) #34 in Dog Flea Drops


#34 in Dog Flea Drops:


Item Weight: 2.56 ounces


Department: Flea & Tick


Manufacturer: Elanco US Inc


Country of Origin: Germany


Item model number: 86336669


Date First Available: March 5, 2011


Item Package Dimensions L x W x H: 6.61 x 4.33 x 1.42 inches


Item Dimensions LxWxH: 1.38 x 4.38 x 6.63 inches


Item Weight: 0.16 Pounds


Brand Name: Advantage


Target Audience Keyword: Dogs


Directions: Application Instructions 1. Use only on dogs. 2. Hold applicator tube in an upright position. Pull cap off tube. 3. Turn the cap around and place other end of cap back on tube. Twist cap to break seal, then remove cap from tube. 4. Apply the entire contents of the tube evenly to three or four spots on the top of the back from the shoulder to the base of the tail. At each spot, part the hair until the skin is visible. 5. Place the tip of the tube on the skin and gently squeeze to expel a portion of the solution on the skin. 6. Do not apply an excessive amount of solution at any one spot that could cause the solution to run off the side of the dog. 7. Do not get this product in your dog’s eyes or allow them to ingest.


Country of Origin: United States


Model Name: Advantage II


Color: Blacks & Grays


Size: 6-Pack


Age Range Description: 7 weeks and older


Care Instructions: Topical Treatment


Number of Items: 6


Style: XL Dog only


Breed Recommendation: Extra Large


Specific Uses for Product: Parasites


Frequently asked questions

If you place your order now, the estimated arrival date for this product is: Sunday, Jun 22

Yes, absolutely! You may return this product for a full refund within 30 days of receiving it.

To initiate a return, please visit our Returns Center.

View our full returns policy here.

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Top Amazon Reviews

    • Thank you!!
Size: 4-Pack Style: XL Dog only
Thank you for refunding our money on one of our lost orders!!! Will keep ordering from you every year !!! LOVE THIS PRODUCT AND COMPANY
Reviewed in the United States on June 13, 2025 by Heather Coltrin
    • good reliable flea killer if used in quantity
Size: 6-Pack Style: XL Dog only
this stuff always works and never fails....i rely on it....i usually apply more than the label advises and so far the product has never caused a problem....its the only product that i consider to be safe for very young puppies as well as older dogs
Reviewed in the United States on May 12, 2025 by W. Dobni
    • Works on battle with fleas
Size: 6-Pack Style: XL Dog only
I have always used Advantage on my two cats and one dog. I just adopted a pit and started her out on this as soon as she got home, since spring is right around the corner. works and she has no side effects, except for no fleas.
Reviewed in the United States on April 19, 2025 by Vikki moelhman
    • Kills fleas well normally, but some seasons fleas are particular difficult to control. This is a bad flea year for my area!!!
Size: 6-Pack Style: XL Dog only
I have used this product for years on my dogs & can normally go as long as up to 8 weeks between doses. I have noticed that on some years (2014 & 2011) that the fleas are particular difficult to control. I know it is not due to this product not being effective because I have treated my yard with 2 different products that normally work very well within a 10 day period & even those products have made very little difference in the fleas. I have treated my dogs at 9 days & repeated again at 13 days. I am also using natural flea shampoo & topical sprays with essential oils. The fleas do die within 12 hours, but by that time my dog with allergies is a mess due to bites before they die. I am now seeing primarily very tiny fleas which tells me that I am achieving some control over the adult fleas. I dislike giving doses that close together, but that is what the insert recommends (actually every 7 days until controlled) for heavy flea infestations. One of my dogs has terrible flea allergies. He has been miserable & has been on prednisone & benadryl for over a month. I don't even like for him to be outdoors because they are so bad. I have to pick fleas off both dogs every time they step outside. I don't have any carpet in my home so I know they are not living in my house. It just seems that some years the fleas are just almost impossible to control. I am in Savannah, Ga. Last summer, the fleas were no problem at all. I did not even treat my lawn. I only gave Advantage every 6-8 weeks. The summer of 2011 was also a bad flea year. I'm not sure what is the cause, probably something to do with the weather or maybe they just have cyclic bad years (who knows). I thought this would be a mild year for fleas because the winter was so cold, but that apparently is not true. I have learned that unfortunately on bad flea years it will take a few months to get the fleas under control even using multiple products. Nothing much else you can do, but suffer until they are under control!!...............Update: After treating my yard with 2 different products within a month & treating my dogs with 3 doses (once every 10 days), the fleas appear to finally be under control. No fleas for 3 days!!! Allergic dog is finally getting some relief. Hopefully, I can now only treat my dogs monthly since I have gotten the severe flea infestation under control. It just takes a while to break the flea life cycle if you have a severe infestation..............UPDATE...Fleas are finally under control. Have not had to re-apply for 4 weeks. Just had a small flea on my allergic dog. Will re-apply today. Once you break the flea life cycle this will control the fleas. I buy the large dog size package & draw out the dosage for each dog with a blunt tip syringe. This is more cost effective & I have found that I can control the fleas by using a smaller dosage for my 30lb dog with allergies. The size package for his weight is a 2.5ml dose (weight range 21-55 lbs). He only weighs 30lbs & the weight limit is a very broad range for his size. The next smaller size range (10 to 20 lbs) is 1.0 ml so at approximately 0.5ml per 10 lbs, I don't feel he needs the entire 2.5ml dose & I have found that he does not. I normally am able to give him only 1.5 to 2.0 ml which will work fine once the severe infestation is under control. I don't like having to give chemicals to my dog & the less the better. He also has skin problems & the Advantage does seem to flare up his skin problems, so less is better. I am also able to give my cat a dose if he happens to pick up an untreated flea (he is an inside cat, but he will occasionally sneak out if he can). The Advantage is the same ingredients for dogs & cats (also confirmed with my vet), but the Advantix is NOT. DO NOT give Advantix to cats! ... show more
Reviewed in the United States on May 10, 2014 by Happy Dog Lady
    • Great item
Size: 4-Pack Style: XL Dog only
Works great
Reviewed in the United States on May 16, 2025 by good game
    • Bought this for my cats(yes, cats)
Size: 4-Pack Style: XL Dog only
I've been dosing down advantage for 2 decades. Sad that multi seems gone as it got 3 types of parasites including tapeworm which often follows flea infestations. YOU CANNOT DO THIS WITH ADVANTIX. As long as the percentage of the active ingredients is the same on the dogs as it is with the cats, it's only a matter of dosage size(you can do this with Frontline too but to me they're as good as hartz in efficacy) so my kitten(2-5lbs) gets 0.23ml and my massive fat cat(over 9lbs) gets 0.8ml. Cats that are 5-9lbs would get 0.4ml. Saves quite a lot. ... show more
Reviewed in the United States on December 23, 2024 by leslie
    • How to Use the "Extra Large Pack" to dose multiple dogs! Saves money on this great product!
Size: 4-Pack Style: XL Dog only
I live in the American South, and my vets agree that Advantage works better than Frontline or any generic products. To get the most value for your money, I recommend buying the dosage for extra-large dogs and splitting it among smaller dogs. Save a small jar such as for pimentos or olives. Ask your pharmacist for a plastic dosing syringe (the kind for giving kids liquid medicine); they will likely give you one. I've attached a sample picture of the type of syringe you need. You need one without a needle that holds the amount of ML you will be using, based on the below guidelines. Take off your dog's collar to ensure it doesn't slide down onto where you will be putting the Advantage. Open a package of Advantage and pour it into the jar. Pull into the syringe the right amount for your dog's weight: 0.4ml = 0-10# 0.8ml = 11-20# 1.2ml = 21-30# 1.6ml = 31-40# 2.0ml = 41-50# 2.4ml = 51-60# 2.8ml = 61-70# 3.2ml = 71-80# You will put part of the Advantage on the dog's neck, and part of it in a few places down his back. Use your fingers to part the dog's hair on the back of his neck. (See package instructions on where to place the treatment.) Slowly depress the plunger onto the skin, NOT on top of the hair. Otherwise, it will drip off of the hair. Do several more spots down the dog's spine. Immediately give treats to keep them from shaking their heads around. I learned the hard way that, if your dog vigorously shakes, this product can take the paint off cabinets and the varnish off stainless steel!! I do the treatment outside and leave the dogs outside for an hour or so. Buying the largest size of Advantage and dosing several dogs with it can save a lot of money in the long run. Let's say your dog weighs 32 lbs, and you purchase the "Large dog for pets 21-55 lbs" and put the entire tube on him. You will be giving him 2.5 ML when he really only needs 1.6 ML. In a home with several dogs, this can add up! Of course, talk to your vet if you have questions. This is just how I do it at my house! I am not a vet. I plan to post a video showing how I use this method. **I have relied heavily on reviews for years, since I do most of my shopping online. I've finally starting trying to return the favor by writing reviews of products I love. I hope my review was helpful to you!** ... show more
Reviewed in the United States on March 26, 2016 by Noah
    • Okay for Relatively Safe, Basic Flea Protection
Size: 6-Pack Style: XL Dog only
I guess it's back to the (relatively overpriced) brand now that the "Advantage II" generics for dogs seem to have all but disappeared, leaving those needing a proven safe product for just flea control, or an appropriately split-dosed option for multiple cats (NOT something that can be done with Advantix etc.) in a lurch. It seems Bayer sold off their Advantage line to Elanco, but hopefully the composition has remained the same and just as effective given that the price has stayed much higher than former equivalents like CrossBlock II and Combiva II. ... show more
Reviewed in the United States on February 22, 2025 by KatKit103

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