SkinMedica TNS Advanced+ Serum - Our Premium Facial Skin Care Product, the Secret to Flawless Skin. Age-Defying Face Serum for Women is Proven to Address Wrinkles and Fine Lines for Glowing Skin,1 Oz
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This item is eligible for return within 30 days of receipt
To qualify for a full refund, items must be returned in their original, unused condition. If an item is returned in a used, damaged, or materially different state, you may be granted a partial refund.
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Features
- Next-Generation, Skin Rejuvenating Formula - A powerful peptide serum that helps target the appearance of fine lines, deep wrinkles and sagging skin. Enriched with TNS-MR, an advanced formula that acts on multiple levels to help get you to your age-defying results. Suitable for all skin types.
- Key Ingredients - In this two chamber visibly firming serum, a next-generation growth factor blend helps to support healthy skin functions while an innovative peptide complex nourishes your skin. In the second chamber, Renessensce (RSC) Advanced is specifically designed to support the results of the growth factor blend, made up of a highly active blend of Marine Extract and Green Microalgae.
- Key Benefits - Additional benefits of this growth factor serum include smoothing the appearance of coarse wrinkles and fine lines, as well as addressing sagging skin with visibile results in just 2 weeks.
- How to Use - Dispense on the back of your hand and blend together before applying to skin. Avoid getting in eyes. If contact occurs, rinse eyes thoroughly with water. Apply this facial serum in the morning and evening after cleansing and toning.
- Our Founding Story - Our founders began a revolution in skin health that continues to fuel the scientific research, innovation, and transformative results we're known for. Our approach to product innovation relies on research and bridging the gap between biological processes, revolutionary formulations, and clinical results.
Product Dimensions : 2 x 2 x 7 inches; 4 ounces
Item model number : 96395
UPC :
Best Sellers Rank: #98,041 in Beauty & Personal Care (See Top 100 in Beauty & Personal Care) #1,987 in Facial Serums
#1,987 in Facial Serums:
Customer Reviews: 4.0 4.0 out of 5 stars (927)
Skin Type: All, Combination, Sensitive
Product Benefits: TNS Advanced+ Serum is proven to smooth the appearance of wrinkles & fine lines, target sagging, & rejuvenate skin.
Target Use Body Part: Face
Scent Name: Aloe
Special Ingredients: Next-generation growth factor blend — supports healthy skin functions
Item Form: Serum
Skin Tone: All Skin Types
Brand Name: SkinMedica
Number of Items: 1
UPC: 300236395100
Model Number: 96395
Manufacturer Part Number: SB-112
Item Weight: 0.25 Pounds
Unit Count: 1.0 Ounce
Material Features: Natural
Active Ingredients: peptides
Recommended Uses For Product: dermatology
Frequently asked questions
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Yes, absolutely! You may return this product for a full refund within 30 days of receiving it.
To initiate a return, please visit our Returns Center.
View our full returns policy here.
To initiate a return, please visit our Returns Center.
View our full returns policy here.
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Top Amazon Reviews
I used this product years ago and loved it. I recently purchased it again to be a part of my skin care routine. This product has been clinically proven to reduce fine lines and wrinkles. It absorbs quickly, and it's super easy to pump out and apply. It does provide a dewy/glowy look once applied. Your skin is soft and with long term use, you will see a changes in your fine lines and wrinkles. It is a little pricey, but I feel that if it does it's job, it's well worth it.
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Reviewed in the United States on August 8, 2025 by DL
TNS Advanced+ Serum — (Real Pro Insight!) After years working closely in the skincare industry, I can confidently say that SkinMedica’s TNS Advanced+ Serum is one of the very few luxury skincare products that actually delivers — when used correctly. I’ve repurchased it many times because it continues to show results that nothing else quite matches — even though the nearly $300 price tag still makes me flinch every time. ⸻ Performance: This Advanced+ version is a serious upgrade from the original TNS Essential Serum. It improves: • Fine lines and wrinkles (especially around the eyes and mouth) • Skin texture (feels smoother and more resilient) • Firmness and elasticity (subtle lift effect) • Tone and overall radiance (especially after consistent use) The texture is much lighter and absorbs faster than the old TNS Essential Serum, without feeling greasy or sticky. It layers beautifully with other treatments — essential if you have a complex routine like I do. ⸻ Key Ingredients (Deep Dive): • TNS-MR (Growth Factor Blend): Over 450 growth factors and cytokines that help stimulate skin regeneration and repair visible signs of aging. • Renessensce (RSC) Advanced: A blend of botanicals and peptides that support cell renewal and longevity. • Hydrolyzed Silk, Peptides, and Polysaccharides: Smooth and hydrate the skin, giving an instant soft feel while working deeper over time. • Antioxidant-rich extracts: Help combat environmental aggressors and oxidative stress. Potential Concerns to Know: • Contains fragrance — it’s minimal and generally tolerable, but still there. • Silicones (Dimethicone) — present for smoother application but can bother acne-prone skin types. • Human fibroblast conditioned media — effective but not vegan. ⸻ The Price Reality: At almost $300 a bottle, it’s a major investment. You’re not just paying for ingredients — you’re paying for decades of research, patented technologies, and clinical trials that back its claims. That said, there are ways to build a routine around less expensive supporting products so you don’t break the bank (and yes — I’ll be sharing exactly how soon, stay tuned!). ⸻ Best Dupe/Alternative (if you’re not ready for $300): • Neocutis BIO•SERUM Firm Rejuvenating Growth Factor and Peptide Treatment It’s another clinical-grade growth factor formula, highly effective, and often runs $100+ cheaper than TNS Advanced+ while still delivering excellent results over time. ⸻ Important SkinMedica Note: Out of all SkinMedica products, only two stand head and shoulders above the rest in my professional opinion: • TNS Advanced+ Serum • AHA/BHA Exfoliating Cleanser Everything else? It’s either overpriced, over-fragranced, or underwhelming compared to newer technologies you can find elsewhere. ⸻ Final Verdict: • TNS Advanced+ works — for smoothing, firming, and rejuvenating the skin. • Crazy expensive — but it’s legitimately one of the best growth factor serums available. • Not a miracle in a bottle — best results happen when you build it into a strong, layered skincare routine (and yes, I’ll be sharing mine soon). • Great for aging skin, texture concerns, and anyone serious about long-term skin health. I will absolutely continue buying this until something even better comes along. Like and follow me here on Amazon if you want real, tested skin advice — including how to layer smarter, when to splurge, and when to save!
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Reviewed in the United States on April 29, 2025 by VanillaPepper
Be aware of subsribe and save for this product. I have subscribe and save for this since it cost alot and it was cheaper that way. I did not need my back up one until today. When I opened it, it would not expel the cream in the right pump. Only the left side of the pump worked. I tried to exchange it, but the last date to return it was in October. I called customer service since Amazon has always been so wonderful to help with problems. However, this time they would not help. It is past the return window, even though it is broken! So my advice to you is it is a wonderful product although it is pricey, I will not buy another for awhile (because of the cost). If you have subscribe and save for this product, my whole reason for this review is to tell you when you receive your bottle check it right away! I wish I had. The only problem with that is now it won't be fresh if you don't need it for awhile. Since this has happened to my pump, I have checked into this product and it looks as though this has been a problem for some with only one side of the pump working. All the more reason to check it works when you receive it.
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Reviewed in the United States on November 26, 2024 by Debbie J Habegger
This really does make my skin look softer, beautiful, and more glowing after using it regularly for a few weeks. I'm in my late 40s and it makes me look softer and younger.
Reviewed in the United States on March 8, 2026 by Jennifer M Edwards
Omg! I’m obsessed with this product! I can tell a difference in my skin in days. I usually buy this from my dermatologist but have bought on Amazon as well. Just make sure if you buy online, the seller is indeed Skin Medica so it’s not counterfeit or a dupe. This product will tighten pores, smooth texture, and make your nature skin glow! Love it so much! Worth the money! For reference I’m 43, have normal/oily skin, & premenopausal.
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Reviewed in the United States on November 29, 2025 by abaarfineart
I use this product in conjunction with a number of other products and techniques so I can’t point to specific improvements, but I’m satisfied there is enough evidence to support continued use. I wait until the price hits 235 or below to purchase. If you check camelcamelcamel, you can see that the price drops frequently enough that you don’t need to pay full price. Now to the pump issue. After finishing one bottle, we busted it open to understand how it works (see photos). How I would recommend “unsticking” a pump that is not dispensing properly is to break off the bottom (chrome) cover to reveal the bottom ends of the dispensers. There are two small holes in each, and by unfolding a large paperclip, you can feed the paperclip through one of the holes to gently push up the plunger/piston to get it moving. Once you do that, the dispenser should start moving on its own. (If you can’t break the bottom cover off, you might try drilling a large hole for access to the sticking dispenser.) FYI there was really no residual product to remaining in the dispensers to collect when they were empty. (One of the photos shows the plungers/pistons in each dispenser all the way at the top with no product remaining.)
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Reviewed in the United States on August 31, 2025 by Ann