SkinMedica TNS Advanced+ Serum - Our Premium Facial Skin Care Product, the Secret to Flawless Skin. Age-Defying Face Serum for Women is Proven to Address Wrinkles and Fine Lines for Glowing Skin,1 Oz
Condition: New
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30-day refund / replacement
To qualify for a full refund, items must be returned in their original, unused condition. If an item is returned in a used, damaged, or materially different state, you may be granted a partial refund.
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Availability:
In Stock.
Arrives
Saturday, Aug 30
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Skin Type: All, Combination, Sensitive
Product Benefits: TNS Advanced+ Serum is proven to smooth the appearance of wrinkles & fine lines, target sagging, & rejuvenate skin. See more
Use for: Face
Scent: Aloe
Special Ingredients: Next-generation growth factor blend — supports healthy skin functions
Product Dimensions : 2 x 2 x 7 inches; 4 ounces
Item model number : 96395
UPC :
Best Sellers Rank: #12,222 in Beauty & Personal Care (See Top 100 in Beauty & Personal Care) #281 in Facial Serums
#281 in Facial Serums:
Customer Reviews: 3.9 3.9 out of 5 stars 866 ratings
Frequently asked questions
If you place your order now, the estimated arrival date for this product is:
Saturday, Aug 30
Yes, absolutely! You may return this product for a full refund within 30 days of receiving it.
To initiate a return, please visit our Returns Center.
View our full returns policy here.
To initiate a return, please visit our Returns Center.
View our full returns policy here.
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Top Amazon Reviews
I used this product years ago and loved it. I recently purchased it again to be a part of my skin care routine. This product has been clinically proven to reduce fine lines and wrinkles. It absorbs quickly, and it's super easy to pump out and apply. It does provide a dewy/glowy look once applied. Your skin is soft and with long term use, you will see a changes in your fine lines and wrinkles. It is a little pricey, but I feel that if it does it's job, it's well worth it.
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Reviewed in the United States on August 8, 2025 by DL
TNS Advanced+ Serum — (Real Pro Insight!) After years working closely in the skincare industry, I can confidently say that SkinMedica’s TNS Advanced+ Serum is one of the very few luxury skincare products that actually delivers — when used correctly. I’ve repurchased it many times because it continues to show results that nothing else quite matches — even though the nearly $300 price tag still makes me flinch every time. ⸻ Performance: This Advanced+ version is a serious upgrade from the original TNS Essential Serum. It improves: • Fine lines and wrinkles (especially around the eyes and mouth) • Skin texture (feels smoother and more resilient) • Firmness and elasticity (subtle lift effect) • Tone and overall radiance (especially after consistent use) The texture is much lighter and absorbs faster than the old TNS Essential Serum, without feeling greasy or sticky. It layers beautifully with other treatments — essential if you have a complex routine like I do. ⸻ Key Ingredients (Deep Dive): • TNS-MR (Growth Factor Blend): Over 450 growth factors and cytokines that help stimulate skin regeneration and repair visible signs of aging. • Renessensce (RSC) Advanced: A blend of botanicals and peptides that support cell renewal and longevity. • Hydrolyzed Silk, Peptides, and Polysaccharides: Smooth and hydrate the skin, giving an instant soft feel while working deeper over time. • Antioxidant-rich extracts: Help combat environmental aggressors and oxidative stress. Potential Concerns to Know: • Contains fragrance — it’s minimal and generally tolerable, but still there. • Silicones (Dimethicone) — present for smoother application but can bother acne-prone skin types. • Human fibroblast conditioned media — effective but not vegan. ⸻ The Price Reality: At almost $300 a bottle, it’s a major investment. You’re not just paying for ingredients — you’re paying for decades of research, patented technologies, and clinical trials that back its claims. That said, there are ways to build a routine around less expensive supporting products so you don’t break the bank (and yes — I’ll be sharing exactly how soon, stay tuned!). ⸻ Best Dupe/Alternative (if you’re not ready for $300): • Neocutis BIO•SERUM Firm Rejuvenating Growth Factor and Peptide Treatment It’s another clinical-grade growth factor formula, highly effective, and often runs $100+ cheaper than TNS Advanced+ while still delivering excellent results over time. ⸻ Important SkinMedica Note: Out of all SkinMedica products, only two stand head and shoulders above the rest in my professional opinion: • TNS Advanced+ Serum • AHA/BHA Exfoliating Cleanser Everything else? It’s either overpriced, over-fragranced, or underwhelming compared to newer technologies you can find elsewhere. ⸻ Final Verdict: • TNS Advanced+ works — for smoothing, firming, and rejuvenating the skin. • Crazy expensive — but it’s legitimately one of the best growth factor serums available. • Not a miracle in a bottle — best results happen when you build it into a strong, layered skincare routine (and yes, I’ll be sharing mine soon). • Great for aging skin, texture concerns, and anyone serious about long-term skin health. I will absolutely continue buying this until something even better comes along. Like and follow me here on Amazon if you want real, tested skin advice — including how to layer smarter, when to splurge, and when to save!
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Reviewed in the United States on April 29, 2025 by VanillaPepper
Be aware of subsribe and save for this product. I have subscribe and save for this since it cost alot and it was cheaper that way. I did not need my back up one until today. When I opened it, it would not expel the cream in the right pump. Only the left side of the pump worked. I tried to exchange it, but the last date to return it was in October. I called customer service since Amazon has always been so wonderful to help with problems. However, this time they would not help. It is past the return window, even though it is broken! So my advice to you is it is a wonderful product although it is pricey, I will not buy another for awhile (because of the cost). If you have subscribe and save for this product, my whole reason for this review is to tell you when you receive your bottle check it right away! I wish I had. The only problem with that is now it won't be fresh if you don't need it for awhile. Since this has happened to my pump, I have checked into this product and it looks as though this has been a problem for some with only one side of the pump working. All the more reason to check it works when you receive it.
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Reviewed in the United States on November 26, 2024 by Debbie J Habegger
I have been using Skin Medica products for 17+ years. The TNS is an Incredible skin cream. When you first start using it, you’ll notice a little redness on your forehead - forget it. It’ll go away. I stopped using it after six months in the beginning just to see if there was a difference in my skin. There was a total difference! I needed more moisturizer. My skin felt dry, the texture looked different and my skin looked dull.. I see that people have problems with the pump. Just shake it or turn it upside down for a little bit and it’ll start coming back out again. As for the price, it takes a year to get rid of this product, using it twice a day religiously. It only takes one pump to cover your whole face and I also do my neck. I usually go brush my teeth to give it a chance to soak in before I put on my moisturizer. I just turned 73 and there is no one who thinks I am even close to my age….I am addicted! This pic is out of the shower, no makeup, no touch up.
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Reviewed in the United States on March 16, 2025 by Podi P Podi P
This product works but it is very expensive and I found that for the price and the amount of product you get is not worth me purchasing it again. I suppose if I only used it once a week it would have lasted me longer. Or if it was in a jar and not a pump. But I used it daily and it was gone in month. One time purchase for me unfortunately.
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Reviewed in the United States on June 22, 2024 by shopoholic
The media could not be loaded. I’ve used this product for a while. My dermatologist recommended and I purchased from them multiple times. When I saw it was available from Amazon, I ordered to save myself a trip to the dermatologist. I opened the box when I ran out of the bottle I was using (I always have the bottle upside down). The pump only worked on one side. I tried a few times and decided to send it back and go to my dermatologist to get it. It’s too expensive to only use 1 of the sides. My past bottle may be a little finicky but they always end up dispensing on both sides. They received my return weeks ago and are still evaluating it. There is literally 3 pumps missing from one side of the bottle because it didn’t work. SkinMedica claims to stand by their product for 30 day. I will update review with outcome. When the pump functions properly, the product works but I am rating today based on dispensing functionality of what I received and potential return issues. Update: it look a very long time but I was refunded. I am updating this to 3 stars because it does work. I can’t give it 5 stars because the pump was defective on two bottles of this so far.
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Reviewed in the United States on May 21, 2025 by ladie107