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Nioxin Hair Fall Defense Intensive Daily Leave-In Hair Treatment | With Niacinamide, Caffeine, Lauric Acid, and Sandalore | For Thicker, Stronger Hair | 2.3 Fl Oz.

  • Based on 681 reviews
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Availability: In Stock.
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Arrives Tuesday, Aug 18
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Features

  • Reduced hair fall - 93% of users noticed less hair in their brush.
  • Better hair resistance - 91% of users noticed improved hair anchorage.
  • Thicker, fuller hair - 93% of users felt they had stronger hair when using our leave-on treatment.
  • Healthier hair and improved hair density - 90% of users noticed a reduction in hair breakage.
  • Free of parabens, sulfates, and colorants.

Package Dimensions ‏ : ‎ 6.1 x 1.69 x 1.61 inches; 2.3 ounces


Item model number ‏ : ‎ 99350182438


Manufacturer ‏ : ‎ Nioxin


Best Sellers Rank: #5,150 in Beauty & Personal Care (See Top 100 in Beauty & Personal Care) #47 in Hair Regrowth Treatments


#47 in Hair Regrowth Treatments:


Customer Reviews: 4.0 4.0 out of 5 stars (693)


Brand Name: NIOXIN


Age Range Description: Adult


Manufacturer: Nioxin


Scent Name: Sandalwood


Item Form: Drop


Active Ingredients: Niacinamide, Caffeine, Lauric Acid, and Sandalore


Hair Type: Thinning


Item Weight: 2.3 Ounces


Number of Items: 1


Item Volume: 70 Milliliters


Unit Count: 2.3 Fluid Ounces


Recommended Uses For Product: *Use daily for visibly thicker, stronger hair.


Frequently asked questions

If you place your order now, the estimated arrival date for this product is: Tuesday, Aug 18

This item is non-returnable:

Non-returnable. Transportation of this item is subject to hazardous materials regulation

View our full returns policy here.

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Top Amazon Reviews


  • Effective!
I wanted to wait until 2 months after use before posting my honest review. I’ve been using Nioxin hair serum consistently for about 67 days. I apply it directly to my scalp (I part my hair into sections, then spray), I then use a scalp massager massaging my scalp for 3 minutes. I’ve been doing this twice a day. My hair is fairly healthy, but I’ve been having issues with shedding since summer. I have fine hair that’s low density. What I’ve experienced since I started using is little to no shedding- definitely shedding less than the normal 50-100 strands. In the 2 plus months I have about 2 inches of hair growth (I purchased one of those hair growth tracking tshirts). I find many serums/oils boast hair growth, but few talk about growth retention. My hair is stronger and most importantly thicker. Overall I love it and find it to be very effective! Now a very small minus is the smell which takes some getting used to. The product has a sandalwood smell which I am not a fan! What I did to “lessen” the smell is I apply 1-2 small sprays closely to my scalp then I spread the serum across my scalp using my finger- I don’t smell anything doing this. The serum doesn’t make your hair oily or greasy after applying. You can use sparingly (1-2 pumps) then use a scalp massager to spread it around. I purchased for 50 USD, but I feel like this will last me 4-5 months even applying twice a day. I don’t think it has protein in it which is great because I am protein sensitive and I find many of the popular hair oils contain protein. Overall it’s a great product and I will continue to use it. ... show more
Reviewed in the United States on December 14, 2023 by G. Brown

  • Unleashing the Power of Nioxin Ultimate Power Serum - Say Hello to Thicker, Stronger Hair
I cannot express enough how impressed I am with the Nioxin Ultimate Power Serum. As someone who has struggled with thinning hair for years, finding a solution that actually delivers on its promises has been a game-changer. This intensive daily leave-in hair treatment has transformed my hair, leaving it thicker, stronger, and more vibrant than ever before. One of the standout ingredients in this serum is caffeine, which works wonders for stimulating hair growth. Caffeine has been shown to promote blood circulation to the hair follicles, resulting in increased hair density and thickness. The inclusion of lauric acid, niacinamide, and sandalore further enhances the serum's effectiveness, nourishing the scalp and promoting healthier, more resilient hair. What sets the Nioxin Ultimate Power Serum apart from other hair treatments is its lightweight and non-greasy formula. I have tried numerous products in the past that left my hair feeling weighed down and greasy, but this serum absorbs quickly and leaves no residue. It is a joy to use and does not interfere with my styling routine. I have been using the Nioxin Ultimate Power Serum for several weeks now, and the results are truly remarkable. Not only have I noticed a significant increase in hair thickness, but my hair also feels stronger and more resilient. I have experienced less breakage and shedding, which has boosted my confidence and allowed me to style my hair with ease. The packaging of the Nioxin Ultimate Power Serum is sleek and convenient. The 2.3 oz size is perfect for travel, ensuring that I can continue my hair care routine wherever I go. The pump dispenser allows for easy and precise application, eliminating any wastage. I highly recommend the Nioxin Ultimate Power Serum to anyone looking to transform their hair. Whether you struggle with thinning hair, hair loss, or simply want to enhance the overall health and appearance of your hair, this serum is a must-have. Experience the power of caffeine, lauric acid, niacinamide, and sandalore, and say hello to thicker, stronger, and more beautiful hair. ... show more
Reviewed in the United States on June 18, 2024 by Hernando

  • Awful smell, caused eczema flare-up :(
I don't know how well this product works because I simply could not get over its pungent fragrance. Gross. Listen, I love Nioxin. I've been an avid fan and daily user of its various leave-in products for years. YEARS. But, this is the first Nioxin product I had to throw out because it just smells SO BAD. The smell is not only pungent and strong, it's just straight-up bad. It smells like an incredibly offensive men's cologne - like cigars, tobacco, whiskey, smoke, and alcohol. It's so strong that it caused an eczema flare-up on my neck!! That was the final straw for me - if it hadn't triggered that eczema flare-up, I would've done my best to ignore the fragrance and I would've continued to use this product to test its effectiveness. But, after just three (3!!) uses, my neck became super red, itchy, scaly, and inflamed. Once I stopped using the product, my skin completely calmed down. I wanted to give Nioxin the benefit of the doubt so, after a long pause, I picked this up again. Bad idea. Alas, just three (3) uses in, once again, my eczema flared-up like crazy. This is definitely a NO-GO for me. Nioxin, can you PLEASE make this fragrance-free or with a lighter fragrance?! ... show more
Reviewed in the United States on April 14, 2025 by Darkyetlovely

  • Helps but not a total savior
I've been using this along with the required shampoo and conditioner from Nioxin for over a year. It has slowed some hair shedding but hasn't stopped it and hasn't caused any regrowth. Probably going to stop all of these soon due to cost and lack of stopping the fallout and no regrowth as others experienced. ... show more
Reviewed in the United States on November 10, 2025 by WtfAmazonNameChanged

  • Caffeine sensitive people be aware
4 stars because I think this really works just isn’t for me. I really wanted this product as it has so many positive reviews for its intended use which is retaining existing hair and cutting down on shedding. I have caffeine sensitivity and did see it was #4 ingredient in the label so I was concerned but I had no way to know if topical application would produce similar results as ingesting caffeine. Well, it did. After 45 minutes it produced a fast heart rate over 160 and adrenaline rush similar to if I had drank too much caffeine. If only lasted an hour versus 4 hours from ingesting. Just be aware if you have this problem but otherwise I hear it works great. Disappears into the hair with no residue and does not affect styling or cause buildup. Wish I could use! ... show more
Reviewed in the United States on December 10, 2024 by Marianne Donato

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