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Neutrogena

Neutrogena On-The-Spot Acne Spot Treatment Cream with 2.5% Benzoyl Peroxide, Gentle Face Blemish Medicine for Acne-Prone Skin, Vanishing Formula, Clinically Proven Day-1 Results, 0.75-Ounce Tube

  • Based on 3,443 reviews
Condition: New
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Availability: In Stock.
Fulfilled by Amazon
Arrives Tuesday, Sep 2
Order within 16 hours and 6 minutes
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Size: 0.75 Ounce (Pack of 1)


Features

  • Acne spot treatment: Targets pimples with gentle 2.5% benzoyl peroxide; Effectively treats breakouts without over-drying or irritating skin, making it ideal for daily use on acne-prone and dry skin types.
  • Vanishing cream formula: Lightweight, fast-absorbing, and invisible on skin; This acne treatment for face delivers lasting results and can be used up to three times daily for clearer, healthier-looking skin.
  • Clinically proven results: Clears skin starting day 1 without stinging or burning; Dermatologist-tested formula goes deep down into pores to kill the acne bacteria that can cause pimples.
  • Gentle for dry and acne-prone skin: Perfect for those seeking effective acne care without over drying or discomfort.
  • Neutrogena On-The-Spot Acne Spot Treatment cream is an effective acne treatment for face in a convenient 0.75 oz tube.

Description

Neutrogena On-The-Spot Acne Spot Treatment Cream with 2.5% benzoyl peroxide is a clinically proven acne spot treatment for face that helps clear breakouts fast without over-drying, stinging, or burning. This gentle vanishing cream formula absorbs quickly, works invisibly, and is designed for acne-prone and dry skin. The lightweight cream penetrates deep into pores to kill acne bacteria that cause pimples and helps prevent new ones from forming. Suitable for daily use, this acne treatment for face can be applied up to three times a day to affected areas. The fast working formula helps maintain skin comfort while delivering effective results, making it an ideal choice for those seeking a gentle yet effective acne spot treatment. The 0.75 oz tube is perfect for targeted application and on-the-go use. This acne spot treatment cream is formulated to address the needs of those with acne- prone and dry skin, providing a vanishing cream that absorbs quickly and leaves no residue. The clinically proven formula is designed to be gentle enough for daily use, helping to reduce the appearance of pimples and helps prevent new breakouts. With its lightweight, non-greasy texture, this acne treatment for face fits seamlessly into your skincare routine. The vanishing cream formula ensures that the treatment works invisibly, so you can use it throughout the day without noticeable residue. Neutrogena On-The-Spot Acne Spot Treatment Cream is an essential addition to your personal care products, delivering targeted acne control and supporting your skin care goals. Trust in a product that combines the power of benzoyl peroxide with a gentle, cream base for effective, visible results. Brand Story By Neutrogena

Item Form: Cream


Scent: Unscented


Brand: Neutrogena


Product Benefits: Hydrating


Skin Type: Dry


Is Discontinued By Manufacturer ‏ : ‎ Yes


Product Dimensions ‏ : ‎ 1.45 x 3.95 x 3.95 inches; 0.75 ounces


Item model number ‏ : ‎ 2620649002


UPC ‏ : ‎


Manufacturer ‏ : ‎ Kenvue


Best Sellers Rank: #1,224 in Beauty & Personal Care (See Top 100 in Beauty & Personal Care) #34 in Facial Serums


#34 in Facial Serums:


Customer Reviews: 4.6 4.6 out of 5 stars 3,443 ratings


Frequently asked questions

If you place your order now, the estimated arrival date for this product is: Tuesday, Sep 2

Yes, absolutely! You may return this product for a full refund within 30 days of receiving it.

To initiate a return, please visit our Returns Center.

View our full returns policy here.

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Top Amazon Reviews

    • A Dermatologist-Approved Miracle Worker for Stubborn Breakouts!
Size: 0.75 Ounce (Pack of 1)
Review Image by Sean Kewalramani Sean Kewalramani
★★★★★ A Dermatologist-Approved Miracle Worker for Stubborn Breakouts! After a decade-long battle with acne, I can confidently say Neutrogena's On-The-Spot Acne Treatment is one of the most effective over-the-counter solutions I've ever used. This 2.5% benzoyl peroxide formula delivers professional-level results without the harsh side effects of stronger prescriptions. Why This Spot Treatment Stands Out: ✔ Clinically Proven Efficacy - Visible reduction in redness and swelling within just 8 hours of application ✔ Gentle Yet Powerful Formula - The 2.5% benzoyl peroxide concentration is strong enough to combat acne bacteria while being gentle on sensitive skin ✔ Vanishing Technology - Leaves no white residue or chalky finish (unlike most BP treatments) ✔ Precision Application - The slim tube allows for targeted treatment without wasting product ✔ Dermatologist Recommended - Backed by decades of Neutrogena's skincare science Real Results I've Observed: Overnight Transformation: 90% reduction in pimple size by morning Preventative Power: Regular use prevents new breakouts from forming Skin-Friendly: No excessive dryness or peeling when used as directed Pro Tips for Best Results: Apply a thin layer to clean, dry skin before bed Follow with oil-free moisturizer if prone to dryness Use at first sign of breakout for maximum effectiveness Final Verdict: This tiny but mighty tube has earned a permanent place in my medicine cabinet. It outperforms more expensive alternatives and delivers consistent results without irritation. For anyone struggling with occasional breakouts or persistent acne, this is hands-down the most reliable spot treatment available without a prescription. Worth every penny - my skin's emergency responder! ... show more
Reviewed in the United States on July 23, 2025 by Sean Kewalramani Sean Kewalramani
    • Great for spots!
Size: 0.75 Ounce (Pack of 2)
This stuff works great! We have it on subscription, so we always have some on hand to take care or spots that pop up.
Reviewed in the United States on August 7, 2025 by Ms.T
    • COMPARABLE TO PROACTIV EMERGENCY BLEMISH RELIEF
Size: 0.75 Ounce (Pack of 1)
I used to love the proactiv emergency blemish relief- it was my go-to and would improve the appearance of a pimple in practically hours. It recently got discontinued because of carcinogenic ingredients (probably why it worked so well lol). Since then, I’ve been on the hunt for a good benzoyl peroxide spot treatment. I had low hopes because this neutrogena one only has 2.5% benzoyl peroxide, but to my surprise, this has been working on my skin wonderfully! It is VERY comparable to the proactiv emergency blemish relief in terms of effectiveness. I will dab a bit on a pimple (or pimples) and the redness/inflammation/size will reduce significantly in hours! If the pimple is under the skin, it will come to a head overnight with the use of this stuff! The consistencies of this and the proactiv emergency blemish relief are somewhat similar as well (gel consistency vs other treatments that are pasty white creams). I’m very satisfied and will continue to have this in my skincare routine as a staple for breakouts!!! ... show more
Reviewed in the United States on August 6, 2025 by Liz Plumeri
    • Fabulous!
Size: 0.75 Ounce (Pack of 1)
At 75 years old I find myself struggling with what seems to be acne. I finally gave up just hoping it would go away with soap and water and witch hazel. ONE treatment of this product showed results! I am amazed and just sorry I waited so long to try it!
Reviewed in the United States on July 6, 2025 by Happy Vegan
    • Neutrogena has great products .
Size: 0.75 Ounce (Pack of 1)
Neutrogena has great products. I use it for my face and it helps contour my psoriasis.
Reviewed in the United States on June 3, 2025 by ANN D
    • Best Acne Spot Treatment Ever.
Size: 0.75 Ounce (Pack of 1)
Best spot treatment for sensitive skin. I have tried many spot treatments and this is best for me. The more powerful ones give you a phase where your skin peals which it stops after a while but this one the phase isn't needed. Never have gotten dry skin with this and it has helped with acne. Like acne spots will be gone within 3 days. This is the first step in healthier skin. ... show more
Reviewed in the United States on August 6, 2025 by Addison
    • Heals red small pimples and doesn’t dry out skin
Size: 0.75 Ounce (Pack of 1)
Works great on a young teenager and doesn’t dry out the skin.
Reviewed in the United States on August 9, 2025 by Amelia
    • Love this more than salicylic acid products
Size: 0.75 Ounce (Pack of 1)
Bought this a couple times since discovering because it instantly transforms my skin. I use it on my whole face for any buried & hidden hormonal spots and overall texture. By morning, my skin feels SO smooth without being overly dry (and I have post-Accutane dry skin). Since doing my one Accutane cycle a decade ago, though, the acne has creeped its way back so I've been toggling between this On The Spot 2.5% benzoyl peroxide and a 2% salicylic acid/witch hazel spot treatment, but the latter definitely dries me out and doesn't seem to have the same calming affect my skin. Huge Neutrogena on the spot fan until it stops working for me, but hope it doesn't. Also, I USE SUNSCREEN everyday to make sure my skin is safe from further sun damage which might also add to my pores being clogged, but I believe it's necessary. ... show more
Reviewed in the United States on June 5, 2025 by JessPaul

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