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medicube Zero Exosome Shot 2,000 PPM Spicule Facial Serum | Liquid Skin Booster Serum | Exosome, AHA+BHA+PHA | Pore Care, Dead Skin Cells, Skin Texture | Korean Skin Care 1.01 fl.oz

  • Based on 2,339 reviews
Condition: New
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Availability: In Stock.
Fulfilled by Amazon

Arrives Tuesday, May 20
Order within 36 minutes
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Pattern Name: 2,000 PPM


Features

  • Viral product beloved by everyone - Transform your skin with the Exosome + Shot Booster. Featuring a micro-sized, needle-shaped design and enriched with 15M patented Exosome shots for precise treatment, this booster delivers active ingredients directly to your pores to tackle various skin issues.
  • Exosome-Coated Technology - Harness the next-generation skincare with Exosome-coated Spicule and Exosome, penetrating deep into the skin to deliver active ingredients effectively. Our advanced formula is designed to address a range of skin concerns, from pore care to enhancing skin vitality and energy.
  • Superior Absorption & Hydration - Achieve unmatched hydration and absorption rates with our formula, which enhances active ingredient uptake by 242% compared to standalone use. Ingredients like Niacinamide and Panthenol boost skin barrier and improve hydration levels, ensuring your skin remains supple and radiant.
  • Clinically Proven & Gentle on Skin - Enjoy peace of mind with our clinically validated Tingling Ampoule that is non-comedogenic, tested to be low-irritating, gluten-free, and free from artificial colors. Suitable for all skin types, including sensitive skin.
  • Easy to Integrate into Skincare Routine - Apply our Tingling Ampoule easily with a three-step routine, starting with a cleansing pad, followed by the Zero One Day Exosome Shot, and finish with a water-based moisturizer like Medicubes Collagen Jelly Cream. For an added boost, use after the "Air Shot Mode" of the AGE-R Booster Pro to maximize effects.

Skin Type: All, Oily, Combination, Sensitive, Dry, Oily Acne Prone


Product Benefits: Blemishes Treatment


Use for: Face


Scent: Aloe


Special Ingredients: minerals, alpha_hydroxy, collagen


Product Dimensions ‏ : ‎ 1.77 x 1.77 x 4.53 inches; 3.17 ounces


Item model number ‏ : ‎ PMEKR14036


Manufacturer ‏ : ‎ Medicube


Country of Origin ‏ : ‎ Korea, Republic of


Frequently asked questions

If you place your order now, the estimated arrival date for this product is: Tuesday, May 20

Yes, absolutely! You may return this product for a full refund within 30 days of receiving it.

To initiate a return, please visit our Returns Center.

View our full returns policy here.

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Top Amazon Reviews


  • Timeless beauty in a bottle
Pattern Name: 7,500 PPM
I purchased this product and it waz shipped out and delivered on time and with care. I used it right away and I want to give a detailed description about this item I received. I washed my face and I put a good amount on my face and it felt cool on the skin and right away you can feel it working. Rubbing it on the skin feels pretty good and than you start to feel a prickly feeling the more you work it into the skin, it doesn't hurt, it just feels like if you got fiberglass on the skin and you only feel that when touching the skin otherwise you wouldn't feel anything. A lil time went by and my skin started to get a slight sunburn look, it's exactly the same feeling as when you use dermaroller or stamp. It really is a needle less product and does the very same thing. Skin will feel warm cause blood is coming up to the skin which you want, to receive younger looking skin. It's plumping and the pores shrink and skin really looks amazing as it's working. The prickly feeling lasts throughout the night till next day and you wake up with a glow which feels good cause that's what we're looking for being age 53. I also added the medicube jelly collagen cream to give it an extra boost of hydration and adding the collagen it helps getting directly into the skin and the 2 together work wonders! This product helps us to deliver other products deeper into the skin so using the 2 is like a powerful regimen together! You will love the results. I used red light therapy to help as well and the 3 together makes the skin look amazing as well! It seems the more you touch your skin, the more you're allowing the product to work actively. Think of it as dermarolling and adding in serum as well as the red light therapy only the dermaroller has needles. I've used many products throughout time and dermaroller has given me the best results and these products here give exactly the same results only i love the outcome much better! I will continue using these products and highly recommend them to everyone who truly wants to get their glow back and look years younger in such a short time. My only regret is waiting to purchase these products but now I have them and plan on purchasing more. The night time mask is next. I compare this to frownies but much better due to me not ripping the patches from the skin and the mask is less invasive and works exactly the same, you're not missing any part of the skin when be able to apply it all over the face. I can't wait till I can update this after a couple of months of using these products. I had to explain in detail due to comments I've seen about how much it hurt cause it was the reason it took me longer to purchase this. It doesn't hurt and I hope you purchase it and try it cause I know you won't regret it at all. You'll be smiling cause as we age, our bodies change and I know I lost the natural glow i used to have and it's all back thanks to these products!! Thank you medicube for amazing products!! You have a lifetime customer here and with my skin only getting younger, I hope I can be someone that can help others to achieve the look we're all looking for at this age. I have and id love to see others look in the mirror and say wow! I like who I'm looking at😉 ... show more
Reviewed in the United States on March 6, 2025 by Cheri Jordan Cheri Jordan

  • Liking This So Far... (w/ update)
Pattern Name: 7,500 PPM
UPDATE 2.14.25: I really really like this stuff. No it isn't the only new thing I've been tinkering with, but it is the only new active I've thrown into my routine. Aside from playing around with some Eight Saints cleanser & scrub, this was about it. I've been using this every other day and rotating it with my tretinoin (I think I even used them on the same night at some point). I use it with my cos de serums vit c & niacinamide (carried in a base HA serum). Your skin will feel smoother than it has ever felt, you'll touch it in the shower after you wash your cleanser away and wonder whose skin you're touching. I'm not kidding. After using it last night and cleansing this morning in the shower, I got out and applied my simple HA serum with a drop each of niacinamide & vit c. Let those soak in while I messed with my hair stuff. I could see shininess on my skin in the mirror. Since I'm a very oily skinned person, I assumed it was oil already from my serums. I was wrong. There was no oil, it was smooth, "dry", shiny glass skin... not "flawless" skin mind you (I have sun damage, sebaceous hyperplasia, and hyperpigmentation from being a Sun Goddess when younger), but clean glowy glass oil-free skin. I was astonished. Texture of my skin has never felt like this. I plan to amp this up and try VT's Reedle shot once I'm done with this bottle and add my serums to that for increased absorption. But as far as this "hydrolyzed sponge" bio-microneedle ingredient stuff goes... very very cool. As someone who has done lots of medical microneedling at home with Dr. Pen, this is an awesome alternative or in between sessions way of maintaining effective skincare ingredient absorption. ORIGINAL REVIEW: Used it for the first time the day I got it. I also routinely use Rx tretinoin cream & Paula's Choice BHA liquid and Mandelic Acid/Lactic Acid liquid. Of course I didn't use any of those when I wore this in the evening after doing an LED mask red light session. Based on other reviews (and b/c I've never used a PHA) I was very apprehensive about the potential "needle" sensation from the spica(?)... ummm, it was like nothing for me, I was actually a little disappointed. I was bracing myself for something worse than microneedling. This did not feel anything close to that. Yes, there were some tingles & prickles here and there, but I've applied 8-10% liquid AHAs to my face before that were WAY more stinging/burning than this was. I'm excited to keep using this item and see how things improve. I plan to adhere to the suggested q3 days and rotate it with my tretinoin. ***The ONLY reason I think my skin is ok with this item from Medicube (I'm still new to their products & dipping my toes after being solely a Cos de Baha, CeraVe, & PC user) is that this is one of the FEW items they have that seems to NOT contain FRAGRANCE! Kudos Medicube... if only all of your products were like that, b/c unfortunately, as much as I wanted to keep the collagen cream, the fragrance was so strong on my face at night that my eyes were burning/stinging from the "fumes" by morning... no bueno Medicube - get the perfume out of your products please!*** ... show more
Reviewed in the United States on February 3, 2025 by SunFish FireMoon

  • Ingredients That Work
Pattern Name: 7,500 PPM
Let me just start by saying—WOW. The Medicube Zero Exosome Shot isn’t just a serum; it’s a whole experience for your skin. This powerhouse product contains 7,500 PPM of spicules (microneedle-like ingredients derived from marine sponges) infused with exosomes—tiny messengers that help regenerate skin and deliver active ingredients deeper than ever before. Translation? It’s like giving your skin a professional-grade treatment right at home or in between spa sessions. The serum has a lightweight, milky consistency that absorbs beautifully. The spicules give a slight tingling sensation, almost like tiny little needles, which lets you know it’s working. It might feel intense to sensitive skin types, but the payoff is worth it. After just a few uses, my skin looked noticeably smoother, brighter, and more refined. It’s excellent for targeting large pores, dullness, and even fine lines. I noticed a more even tone and an overall glow—yes, that “glass skin” vibe! This formula includes not only exosomes but niacinamide and peptides, which work together to firm, brighten, and boost your skin barrier. If you’re serious about anti-aging and skin rejuvenation, this one deserves a spot in your routine. I love pairing this with a cooling jelly mask after use to calm the skin while letting all the goodness soak in. It’s a great post-facial booster or a weekly treatment if you’re doing self-care from home. I give the Medicube Zero Exosome Shot a solid 10/10. It’s clinical-grade care in a bottle—and perfect for anyone who wants results with a bit of spice. (Not pain—but definitely a tingle!) Just remember to moisturize well afterward and always wear your SPF, beauties. ... show more
Reviewed in the United States on April 12, 2025 by Cassandra

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