Differin Acne Treatment Gel, 30 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 15g Tube (Packaging May Vary) | 30-Day Supply, OTC Retinoid, Clears Acne & Prevents Breakouts, Gentle For Sensitive Skin, Dermatologist Recommended
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Availability:
In Stock.
Arrives
Saturday, Jul 25
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Style: Tube
Size: 30 Day Supply (15g)
Features
- TARGETS ACNE: Clears breakouts where they start (Deep in pores) and prevents new acne from forming, which ultimately restores skin's texture and tone
- CLEARS, TREATS & PREVENTS: Differin works differently than other Acne treatments by normalizing skin cell turnover and effectively targets two primary causes of Acne, clogged pores and inflammation
- RX STRENGTH ACNE RETINOID: Adapalene was created for superior tolerability compared to other prescription retinoid products not containing Adapalene; It is suitable for use as part of your morning or evening regimen
- DERMATOLOGIST RECOMMENDED: Water based formula, oil free, alcohol free, fragrance free, non comedogenic; Helps reduce the risk of scarring and Hyperpigmentation by treating Acne
- REAL RESULTS: In a clinical study, Differin gel provided up to 87 percent reduction in acne breakouts after 12 weeks, which will continue to improve with further use
Description
Differin Gel Acne Treatment contains adapalene, an Rx-strength acne-fighting retinoid that helps clear breakouts where they start (works deep into pores in 5 minutes), helps prevents new acne from forming, and as a result, can restore skin's overall tone and texture. Adapalene is the first over-the-counter active ingredient for acne in more than 30 years. It clears acne with the power of an Rx without the prescription, prevents breakouts, blackheads, whiteheads, blemishes and clogged pores, and can be used to effectively treat acne, or maskne, caused by wearing face masks or facial coverings. When used as directed, you could start to see results in as little as 1 week, and when used every single day, Differin Gel can help reduce up to 87% of acne in just 12 weeks (Cunliffe et al 1998, Galderma Laboratories).
Is Discontinued By Manufacturer : No
Product Dimensions : 1.5 x 2.1 x 6.5 inches; 1.25 ounces
Item model number : 0299.492030
Department : Beauty & Personal Care
UPC :
Manufacturer : Galderma Laboratories, Inc
Best Sellers Rank: #210 in Beauty & Personal Care (See Top 100 in Beauty & Personal Care) #2 in Facial Skin Care Sets & Kits
#2 in Facial Skin Care Sets & Kits:
Customer Reviews: 4.5 4.5 out of 5 stars (71,488)
Item Form: Gel
Scent Name: Unscented
Product Benefits: Anti-Acne
Skin Type: Acne Prone, Sensitive
Special Ingredients: adapalene 0.1% (retinoid)
Target Use Body Part: Face
Active Ingredients: Adapalene 0.1%
Container Type: Tube
Brand Name: Differin
Global Trade Identification Number: 03
UPC: 302994920303 302994910151
Manufacturer Part Number:
Model Number: 0299.492030
Manufacturer: Galderma Laboratories, Inc
Item Type Name: Retinoid
Item Weight: 0.08 Pounds
Item Volume: 0.5 Fluid Ounces
Size: 30 Day Supply (15g)
Material Features: Fragrance Free
Frequently asked questions
If you place your order now, the estimated arrival date for this product is:
Saturday, Jul 25
Yes, absolutely! You may return this product for a full refund within 30 days of receiving it.
To initiate a return, please visit our Returns Center.
View our full returns policy here.
To initiate a return, please visit our Returns Center.
View our full returns policy here.
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Similar Products
Top Amazon Reviews
Style: Tube
Size: 30 Day Supply (15g)
I have been using Differin since 2022 until now. A little bit does go a long way, and it has been helping me with my acne a lot. In my experience, the purge happened around 6-8 months of using it, and it lasted pretty long on my skin (about 3-4 months) :(((( But when it stopped, my skin started to clear up. I still get acne occasionally, but most of the go away after 1-2 days, so not an issue at all. I would say that because my skin is very sensitive. I am more prone to having skin reactions or damaged skin barrier everytime the weather changes or the water is a bit hotter than usual, I have to stop using Differin until my skin feels better again. Patience and a good moisturizer are key in this.
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Reviewed in the United States on June 1, 2026 by Vy Nguyen
If you don't read any further in my review, please know this: IT GETS A LOT WORSE before it GETS MUCH BETTER. HANG IN THERE. I'm posting this in hopes this helps someone. First, some history: I've struggled with moderate acne from my teenage to adult years. In my early and mid 30s, my acne has turned into painful cysts that predominantly cover my cheeks, jawline and neck. I also have breakouts on my shoulders, back and chest, though they aren't anything like my face. The areas I break out in would lead me to believe it's hormonal. Since I've also had hair loss and have had cysts on my ovaries, there was a thought it was PCOS, but dozens of blood tests and expensive doctor visits later, that was ruled out. I spend COUNTLESS, and I mean COUNTLESS hours researching about acne. It's ruined my self-esteem and confidence, I never feel attractive, and I even have trouble looking at people sometimes. My skin is PAINFUL due to the deep cysts and inflammation. So much so, some days I just wanted to cut my skin off. It's been hard not to pick, but of course even if I don't, my skin is left with red marks that are just has hard to cover up as the inflamed bumps. I've tried EVERYTHING over the years. You name it, I've tried it, and that includes Acutane (but I wouldn't stay on it due to concerns over liver damage). The only thing I haven't tried that I heard could work is Spirnolactane. I was actually prescribed it but decided not to take it, again, over concerns about what it would due to my health. I don't even know how many dermatologist, primary care and OB/GYN appts I've had to discuss the matter. One derm went so far as to tell me, "If you still have acne at this age, you'll always have acne." In other words, I'm hopeless. I hated that guy. That was told to me when I was around 22 and I've never forgotten it 13 years later. Recently, I moved to a new town and got a facial. The woman that was treating me suggested Differin Gel. She mentioned she'd seen some success with it and that it was a fairly new OTC product. I figured, what in the heck do I have to lose. Desperate, I ordered it from Amazon. And after using it for the first time, I BROKE OUT EVERYWHERE, particularly my forehead. It was AWFUL. My only patch of clear skin was now what seemed to be infinite whiteheads. Every pore was a whitehead. It was awwwwwful!!! I immediately quit the product, and was so angry that another thing failed me. It took WEEKS for the whitehead breakout to clear up. While I waited, I kept researching it. I don't know why. And I read how people talked about it "purging" the skin so people get a bad initial breakout. Ok. Well, I don't know if it was out of frustration or a little nagging gut feeling, I decided to try it again. AND MY SKIN GOT SO RED AND DRY AND BURNED SO BADLY. I mean, excruciatingly painful. And it turns out that's just because I was coating on a thick layer of it all over my skin. How embarrassing showing up for work and my whole face is just red and massive FLAKES. But after all that flaking and peeling, and using non-stop aloe on it (also borrowed my husband's thick Aveeno Eczema lotion... it seems to really work!), I had.... clear skin. I can't believe I'm typing this. It's been weeks, and my skin has cleared up 98% (I did have a couple neck and jawling cysts this period cycle, though - but they're not as hidden under the surface as they used to be). My skin doesn't get nearly as oily (overcompensating for the dryness of Differin) or as flaky (because I'm using a little bit for the whole face with a little more added onto my problem areas). It seems to have finally balanced out. I really just can't believe it, and I am so unbelievably happy and feeling so much more confident than I have in a long time. I truly hope this helps someone. Shoot me a question on here if you have one and I'll be happy to answer. For the record, after a ton of my own research, I believe I have a sensitivity to DHT. My blood test DHT levels are normal, but as I understand it, sensitivity to DHT cannot be measured, and I believe that may explain my female hair loss and cystic acne. I recently purchased Saw Palmetto Extract to see if that can help -- though it made me feel very faint so I stopped after a third day.
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Reviewed in the United States on March 29, 2018 by lkwilson06
I have been using Differin for over a year now (around 14 months giver or take) and did not publish a review until now. If you want an in-depth review, read on. For the tl;dr version: it works, just stick with it. Btw, I was not paid for this nor was I sent this product (although they should be sending it, given how many tubes I've bought). I had the MOST TERRIBLE acne. No, I'm not talking about a small tiny excuse of a blemish that your friend with great skin complains about when she has her "bad skin" days. My face was RED and PAINFUL. My cheeks were COVERED all the time, and I had no area on my face where acne wouldn't pop up. Nose, brows, chin, jaw, underneath the jaw, you name it. I had tried Curology and while my skin got amazing for the first 6 months, my acne returned with a VENGEANCE. I had tried so many things, clay masks, benzoyl peroxide, salicylic acid, other AHAs and BHAs, sulfur, rosehip oil, and even supplements like zinc and milk thistle, you name it. Nothing worked at all. I was so so embarrassed of my skin, but I couldn't wear makeup either since makeup made my acne SO MUCH worse. I heard about Differin and I figured "well, might as well give this a try cause it can't get any worse". Boy, I was wrong. It did get worse. Much worse. Suddenly I had SO much more acne and I felt like crap. I couldn't believe my skin could get worse, but it did. Differin was the only thing I was using so I knew this was it. I was depressed but I stuck with it, cause I wanted to test it for at least 4 months. I thought I might as well test the claim, since my skin is so bad already. The first month was really really bad. It brought all underlying acne to the surface i.e. the purge phase. It did the purging for 3-4 months, but the first month was THE WORST. Not gonna lie to you, that first month will probably be the worst skin you've had in your life. Your skin will become SO SENSITIVE! Anticipate that! My skin has never been sensitive to products but while using this, my regular moisturizers and masks would sting like crazy (get stuff with no fragrance/alcohol or acids!). It didn't affect my skin in any other way, it just stung a lot. Oh, and I used to get my upper lip and brows waxed. Not with this you can't, the wax will tear off your skin since it gets much more sensitive. I learned the hard way. ONLY do threading! However, after I waited out the terrible, terrible first month, I slowly began to see improvements. Marginal, though. I had acne, but I probably had just a tad less. And it continued that way, it kept improving. Eventually, my skin was so much clearer than before! I still had acne, mind you, it's not a miracle drug, but it was few and far in between. There would be times when I had no active acne, which was HUGE for me!! My face usually looked like a connect the dots game. However, I did hit a plateau. This worked phenomenally at reducing my ugly acne all over my face to a few zits here and there, however, my issue was deeper than that. Eventually, I went to a doctor and got on spironolactone. Now, I am both on my Spiro and this. The combo of these two have made my skin so clear! I could have never imagined this day! I still need to use this, I have noticed my Spiro is not enough to keep zits at bay and if I skip a couple of nights putting on differin, new zits come up. I am so much happier now that I don't have zillions of gross zits on my face. I still get zits if I eat sugar or near my period but man, I am a long way from before! I have a few blemishes left over from before but I honestly don't care, my skin looks wayyy better. I can hide my blemishes with a sheer foundation of spot concealing if I want. So if you've read till the end, the lesson is: be PATIENT and be realistic! Your acne did not appear overnight and will not disappear overnight. If you stick with this, it WILL work. However, your mileage may vary. My acne was extremely bad, so after I hit my "acne plateau" I went to the doctor. If your acne is not as bad, it's likely differin is all you need for clear skin! If you're on the fence, confused, depressed, frustrated and/or can't afford a doctor, it's worth a shot! Just be patient and gentle with your skin!
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Reviewed in the United States on June 9, 2018 by Biryani
Here is what I did to avoid the fate of purging and negative skin rashes..... Don't: 1) Don't use on raw EXFOLIATED skin. Wait a couple days after exfoliating. 2) Don't use a SUDSING cleansing soap prior. Use a mild hydrating Cleanser. 3) Don't use after getting your skin waxed or shaved. 4) Avoid hot water and steam before use. 5) Do NOT go stand in the sun after applying (retin works by thinning the top layer of your skin which is usually used for protection against the sun). Don't take your chances! 6) do not apply to eyelids or neck or other thin skin areas including the inside of your wrists. You can apply Vaseline to these areas if needed to protect them. 7) don't freak out if your face flakes and don't scrub the flakes off. Moisturizer is your friend. 8) don't scratch at your skin if itches or burns, stay calm, rinse it off with cool water. Apply a gentle cream and then apply a cool wash cloth. Consider diluting before using again. 9) don't assume because your neighbor next door can use twice a day on fresh scrubbed skin with no adverse effects, that the same will be true for you. Adverse skin reactions can take weeks or months to heal from. 10) do NOT apply generously all over your skin. Pea size only on face. Do: 1) plan on using once or twice a week at first for the first month. Remember "sparingly" is your motto. 2) Have a natural moisture barrier on your face first. Be sure you have not scrubbed your skin raw or clean prior and make sure face is danp prior to applying. 3) if you have ultra sensitive skin, apply a gentle moisturizer FIRST before applying differin. Allow to dry before applying differin. 4) do apply a creamy moisturizer after if needed. Wait five minutes before you do. 5) do also apply sunscreen RELIGIOUSLY if you will be outdoors. So important!!!! 6) do research "purging" and what you can do to minimize or avoid it. 7) do remember that this product is a MEDICATION and not your typical OTC cream. Use sparingly and with caution. 8) do remember that moisture is your friend. After cleansing, avoid drying your skin with towels. Avoid air drying as well. 9) do remember that with this product "less is more". It is potent stuff! Once or twice a week treatments alone will make a difference. 10) keep a good repair Cream on hand in possible event of harsh reaction or irritated skin. I recommend "first aid beauty ultra repair cream". This stuff is amazing. Hydrocortisone cream can also be used. MOST IMPORTANTLY: it takes 6-12 weeks of patient and measured use before seeing positive long term results for acne. It can take up to a year before seeing positive results for aged and wrinkled skin. MY RESULTS: I started out at a twice a week and had no reaction except for mild redness, itching and tingling the following two days afterwards. When I tried to increase to three days a week, I started having issues. The solution to this was to revamp my skin care routine (listed below). After that, I was able to switch pretty rapidly to nightly use. The GAME CHANGER was adding First Aid Ultra Hydrating Cream. I've included my before and six week after photos. My acne is gone and my pores most definitely shrunk. I used the same room and lighting and I notice that my skin has become much brighter and lighter. My guess is in removing the thing top layer of skin, we no longer see the old tanned skin I had. So far, I am happy with the results. I am 38 years old. My long term goal is to prevent deep wrinkles and shrink my pores and hopefully reduce white Milia bumps under my eyes as well as all random acne and age spots. I know from researching this can take months and years so I'm feeling patient. MY CURRENT DIFFERIN APPLICATION: My morning routine: - CereVe Hydrating Cleanser - After rinsing, I apply Timewise Vitamin C Serum with the added F acid. - Then, I apply a thin layer of Sunscreen: La Roche-Posay Anthelios with Mexoryl SX OR CeraVe SPF 30. *note: I believe the Vitamin C Serum helped with quicker skin cell turnover rate to prevent purging. In the evenings: - I double cleanse: first I use Yes To Coconuts Uktra Hydrating Creme Cleanser. After I rinse that off, I cleanse with CeraVe Hydrating Facial Cleanser. - I allow skin to stay damp. - I then apply a pea size amount of differin to my face (never on neck or eyelids). - after about minutes, I follow that with First Aid Beauty Ultra Repair Cream. - I apply CeraVe Skin renewing Serum to my eyes and neck and chest. - note: I only use retin A products at night to decrease sun sensitivity. In the mornings, I use all my other acids and Vitamin C. Be aware that most of the negative reviews on here are mostly due to user error and lack of knowledge in the product. There is no reason to have terrible breakouts or harm your skin. I'm horrified people are using this on their NECK right away. Poor skin! This is a potent product. Good luck!
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Reviewed in the United States on January 1, 2018 Reviewed in the United States on January 1, 2018 by Private Profile
Style: Tube
Size: 180 Day Supply (90g)
This works really well (so far). I’ve had acne since I was in middle school and I thought once I hit 18 or so that it would go away but sadly it did not. For the first 7-8 weeks using this my acne was pretty bad and my face was really sensitive. Entering now my 9th week of using this, my acne is almost completely gone and my skin is no longer sensitive. Pretty much a night and day difference. I’m going to continue to use this and see how it goes but for right now I feel amazing and am extremely surprised at the effectiveness of this. I’m hoping with continual use and continual face washing that my acne will disappear completely.
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Reviewed in the United States on March 31, 2026 by logan
Style: Tube
Size: 30 Day Supply (15g)
My face starting purging after using retinol. My face was bright red with big acne covering majority of my cheeks, chin, n lip. I tried waiting out the purge but it was going strong for over a month. I started using this and already day 1 alot of redness went away and the pimples were minimizing. It's been a week and while this is extremely drying it has cleared up the acne and left no scarring
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Reviewed in the United States on June 16, 2026 by Kitten0Uzumaki
Style: Tube
Size: 30 Day Supply (15g)
Differin also known as adapaline, is always the standard that dermatologists recommend when you start. It's a retinoid, but it also stronger on the skin... for most people, this is enough and really helps the skin, it is popular and recommended for a reason... My dermatologist told me to use it on my face and body. She said to expect a skin purge, some irritation, and a bit of peeling at first, but I would adjust to it... I'm stubborn, and at first it kind of hurt on my face and neck, but I expected that. Then it started getting worse instead of better. I should have listened to my body and stopped when it wasn't getting better. But I didn't, and I ended up with a chemical burn and she had to write an rx for Triamcinalone cream to deal with it, mostly on my neck it had a hard time healing and it stung... a lot. And took a long time to fully heal, now it is fully healed and you can't tell it happened. On my body, it was fine and remained fine (though, my body has developed a resistance to it and it no longer works so I'm only using it every so often if the acne on my back is particularly bad. Like I said, it is recommended for a reason and most people it is successful in helping. But absolutely do a spot test, and even then, if it starts feeling worse more than better, stop using it rather than trying to push through. Also note, if you are using it. Don't forget sunscreen. It makes you more sensitive to the sun. And also if you are using it on your face and body, a 90 day supply is a good option because it lasted me about 30 days.
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Reviewed in the United States on April 15, 2026 Reviewed in the United States on April 15, 2026 by K
This is not for mild acne. I don't think people with moderate acne should use this as a first resort, either. This is a retinoid if I remember correctly. It speeds up cell turnover, and increases photosensitivity. If you're using this, you MUST use a sunscreen, or acne scars will be more pronounced, your skin will get sun damage easily, and overall not look as great as this product can make you look. Do some research on sunscreens without comodegenic ingredients. I've been using the one month tube for about two months now, and I've used about 1/3-1/2 of the tube. You really don't need much. You want to apply as little as possible, and start out using it only once a week. Otherwise, your skin, starting to speed up it's cell turnover process, will start to peel, flake, among other unpleasant, dry and crackley negative effects. This can and will destroy your moisture barrier, making it 50 times easier for anything and everything to break you out. DON'T DO IT. How and when to use this: When you're getting INFLAMMATORY acne. If you're just getting blackheads and whiteheads, you can try a BHA or AHA, and start using 1-2 times a week. These are much less harsh and have a good chance of working exactly as intended. If you frequently get pustules, papules, cysts and nodules, this may be a good option for you. If you get a lot of cysts/nodules, go see a dermatologist. They can give you something stronger that will work better for you. This can also be used for texture issues, hyperpigmentation, and the like, but I recommend starting with a lower dose of an AHA product, because they are much less harsh and typically do a better job (faster, too) at fixing those issues. My issue: since 4th grade, I've had acne. I started to get cystic acne in 7th grade, and now as a college freshman, it was getting kind of annoying. I was rotating a BHA/AHA around before using this. Those worked okay, but I still had what would be considered moderate acne- not good. I DO have seborrheic dermatitis on the scalp, so it's possible I also suffer from pittysporum folliculitis (spelling may be wrong,) aka fungal acne, on the face. That BHA/AHA combo, along with a mostly Asian, hydration intensive routine, didn't do enough. My moisture barrier was incredible, though. I've used it two months now. You're supposed to wait THREE months to start seeing any true effect. This is not for the impatient. DO NOT use this with any other acne product. You need a gentle cleanser, a hydrating toner/essence/serum/Ampoule, a moisturizer, and a good sunscreen to use in the morning. An oil cleanser is also a good idea to make sure you remove all sunscreen at the end of the day. What I've noticed: The only times I get deep, painful acne, are the days where I miss that spot. I'm getting blackheads less and less. I'm getting whiteheads, but much less frequently. Nodular acne? Nope, not since before I started. Cystic acne? A few, but I'm getting them less and less. Papule/pustule/other? Still getting some, but nothing like I used to. Mostly in under eye area which is too sensitive for differin. I have not paid attention to my scarring/redness, because I use other products for those. I do think my texture is a bit worse, but I intend to work on that more once my acne is maintained. I started at once a week. Skin handled it, no problem. Went up to twice. Doing fine. Decided to go up to four times because I'm a rebel (translation: impatient.) Then, did every other day. Now I'm using it daily. My skin is a tad overexfoliated, so I've cut back to 6 times a week for now, but it's working very well. Please note: my skin can handle using 5 different high percentages of BHA products at once. Most people's skin cannot tolerate that. Slowly work your way up. Do not expect immediate effects. Use sunscreen and an oil cleanser to remove it. HYDRATE- no one is too oily for a moisturizer. I have very oily skin and the right moisturizer/toner only help, and can make you less oily. Don't overdo it. And lastly, BE PATIENT. I'm trying to work my way to being able to tolerate differin and my BHA. Not everyone can do this. This will not work for everyone, because everyone's skin is different.
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Reviewed in the United States on January 8, 2018 by Sarah K. Whiteley