Differin Acne Treatment Gel, 30 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 15g Tube (Packaging May Vary)
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FREE refund/replacement until Jan 31, 2026 Learn more
This item's return window has been extended for the holiday season: FREE refund/replacement until Jan 31, 2026
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Availability:
In Stock.
Arrives
Tuesday, Dec 16
Style: Tube
Size: 30 Day Supply (15g)
Features
- TARGETS ACNE: Clears breakouts where they start (Deep in pores) and prevents new acne from forming, which ultimately restores skin's texture and tone
- CLEARS, TREATS & PREVENTS: Differin works differently than other Acne treatments by normalizing skin cell turnover and effectively targets two primary causes of Acne, clogged pores and inflammation
- RX STRENGTH ACNE RETINOID: Adapalene was created for superior tolerability compared to other prescription retinoid products not containing Adapalene; It is suitable for use as part of your morning or evening regimen
- DERMATOLOGIST RECOMMENDED: Water based formula, oil free, alcohol free, fragrance free, non comedogenic; Helps reduce the risk of scarring and Hyperpigmentation by treating Acne
- REAL RESULTS: In a clinical study, Differin gel provided up to 87 percent reduction in acne breakouts after 12 weeks, which will continue to improve with further use
Description
Differin Gel Acne Treatment contains adapalene, an Rx-strength acne-fighting retinoid that helps clear breakouts where they start (works deep into pores in 5 minutes), helps prevents new acne from forming, and as a result, can restore skin's overall tone and texture. Adapalene is the first over-the-counter active ingredient for acne in more than 30 years. It clears acne with the power of an Rx without the prescription, prevents breakouts, blackheads, whiteheads, blemishes and clogged pores, and can be used to effectively treat acne, or maskne, caused by wearing face masks or facial coverings. When used as directed, you could start to see results in as little as 1 week, and when used every single day, Differin Gel can help reduce up to 87% of acne in just 12 weeks (Cunliffe et al 1998, Galderma Laboratories).
Item Form: Gel
Scent: Unscented
Brand: Differin
Product Benefits: Anti-Acne
Skin Type: Acne Prone, Sensitive
Is Discontinued By Manufacturer : No
Product Dimensions : 1.5 x 2.1 x 6.5 inches; 0.48 ounces
Item model number : 0299.492030
Department : Beauty & Personal Care
UPC :
Manufacturer : Galderma Laboratories, Inc
Customer Reviews: 4.5 4.5 out of 5 stars (69,878)
Frequently asked questions
If you place your order now, the estimated arrival date for this product is:
Tuesday, Dec 16
Yes, absolutely! You may return this product for a full refund within 30 days of receiving it.
To initiate a return, please visit our Returns Center.
View our full returns policy here.
To initiate a return, please visit our Returns Center.
View our full returns policy here.
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Top Amazon Reviews
I have been using Differin for over a year now (around 14 months giver or take) and did not publish a review until now. If you want an in-depth review, read on. For the tl;dr version: it works, just stick with it. Btw, I was not paid for this nor was I sent this product (although they should be sending it, given how many tubes I've bought). I had the MOST TERRIBLE acne. No, I'm not talking about a small tiny excuse of a blemish that your friend with great skin complains about when she has her "bad skin" days. My face was RED and PAINFUL. My cheeks were COVERED all the time, and I had no area on my face where acne wouldn't pop up. Nose, brows, chin, jaw, underneath the jaw, you name it. I had tried Curology and while my skin got amazing for the first 6 months, my acne returned with a VENGEANCE. I had tried so many things, clay masks, benzoyl peroxide, salicylic acid, other AHAs and BHAs, sulfur, rosehip oil, and even supplements like zinc and milk thistle, you name it. Nothing worked at all. I was so so embarrassed of my skin, but I couldn't wear makeup either since makeup made my acne SO MUCH worse. I heard about Differin and I figured "well, might as well give this a try cause it can't get any worse". Boy, I was wrong. It did get worse. Much worse. Suddenly I had SO much more acne and I felt like crap. I couldn't believe my skin could get worse, but it did. Differin was the only thing I was using so I knew this was it. I was depressed but I stuck with it, cause I wanted to test it for at least 4 months. I thought I might as well test the claim, since my skin is so bad already. The first month was really really bad. It brought all underlying acne to the surface i.e. the purge phase. It did the purging for 3-4 months, but the first month was THE WORST. Not gonna lie to you, that first month will probably be the worst skin you've had in your life. Your skin will become SO SENSITIVE! Anticipate that! My skin has never been sensitive to products but while using this, my regular moisturizers and masks would sting like crazy (get stuff with no fragrance/alcohol or acids!). It didn't affect my skin in any other way, it just stung a lot. Oh, and I used to get my upper lip and brows waxed. Not with this you can't, the wax will tear off your skin since it gets much more sensitive. I learned the hard way. ONLY do threading! However, after I waited out the terrible, terrible first month, I slowly began to see improvements. Marginal, though. I had acne, but I probably had just a tad less. And it continued that way, it kept improving. Eventually, my skin was so much clearer than before! I still had acne, mind you, it's not a miracle drug, but it was few and far in between. There would be times when I had no active acne, which was HUGE for me!! My face usually looked like a connect the dots game. However, I did hit a plateau. This worked phenomenally at reducing my ugly acne all over my face to a few zits here and there, however, my issue was deeper than that. Eventually, I went to a doctor and got on spironolactone. Now, I am both on my Spiro and this. The combo of these two have made my skin so clear! I could have never imagined this day! I still need to use this, I have noticed my Spiro is not enough to keep zits at bay and if I skip a couple of nights putting on differin, new zits come up. I am so much happier now that I don't have zillions of gross zits on my face. I still get zits if I eat sugar or near my period but man, I am a long way from before! I have a few blemishes left over from before but I honestly don't care, my skin looks wayyy better. I can hide my blemishes with a sheer foundation of spot concealing if I want. So if you've read till the end, the lesson is: be PATIENT and be realistic! Your acne did not appear overnight and will not disappear overnight. If you stick with this, it WILL work. However, your mileage may vary. My acne was extremely bad, so after I hit my "acne plateau" I went to the doctor. If your acne is not as bad, it's likely differin is all you need for clear skin! If you're on the fence, confused, depressed, frustrated and/or can't afford a doctor, it's worth a shot! Just be patient and gentle with your skin!
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Reviewed in the United States on June 9, 2018 by Biryani
Style: Tube
Size: 30 Day Supply (15g)
Overall I was surprised by the results and effectiveness of this product. Im writing this review a month after using this adapalene gel because I wasn’t sure how well it was going to work. A month ago I had been dealing with a bad breakout on my forehead, temples, and jawline. I had been using either salicylic acid treatment or benzoyl peroxide on my face. Neither of those products made my situation any better. This product has been on my saved for later list for a while so I was curious to try something different for once. The first week and a half I didn’t see much change. But by week two and three, my goodness my acne nearly vanished. And I’m not exaggerating. It’s been a month now of wearing this every night after my nighttime routine. My face is smooth, acne and bumps are almost completely gone. Even the dark scars from some acne have gone away. It works really well and the 30-day supply really does last for 30-days. The skin around my eyes do dry out with this product, so I’ve been applying Vaseline to help with the excessive dryness. Otherwise this product really helped in just one month use. I spot treated acne on my chest and shoulders every now and then and this works for body acne too. I’m very impressed with the results. 95% of my acne is gone, with some trouble areas like my temples. But it’s helped a lot. I wish I took comparison photos to show the difference.
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Reviewed in the United States on December 8, 2025 by A. Vega
Style: Tube
Size: 60 Day Supply (30g)
As someone who struggled with persistent, stubborn breakouts that other products couldn't tame, finally trying Differin Gel was a complete game changer for my skin. The first two weeks required patience and a good moisturizer as my skin adjusted to the 0.1% adapalene, but sticking with it was worth it; this retinoid has effectively cleared up my active acne and has been incredible at preventing new pimples from forming. Now, after using it for more than twenty days, my complexion is not only clearer but also smoother and more even toned, with a noticeable reduction in the leftover marks from past blemishes. It's the most effective and reliable product I've ever incorporated into my skincare routine, and I wholeheartedly recommend it to anyone on a similar journey to achieve calmer, healthier looking skin.
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Reviewed in the United States on November 5, 2025 by LevelUpLegacy
Style: Tube
Size: 60 Day Supply (30g)
This really works better than any other otc product I've used before. If you're struggling with acne, I'd recommend at least trying it. I'm really happy with the results. Helps lighten dark spots and draw up those hard knots and inflamed bumps go down within couple days. I'd get those itchy random bumps that show up out of nowhere around my jawline. It would go down and come back in same spot all the time. This really works to get rid of those and my skin texture has improved. I have extremely sensitive thin skin. I saw some of the other reviews with some having little results or adverse reactions and was a little nervous about using this product. However, there were many with very good results so I tested on small area for the first week. I used small amount and within 4 days I could see it was working well. Moved on to spot treating all over face and no severe side affects so far. No redness, swelling or skin peeling. Very happy with results so far, but the box is huge compared to size of product inside. It's tiny, about the size of my finger.
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Reviewed in the United States on September 2, 2025 by JYP