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Differin Acne Treatment Gel, 30 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 15g Pump (Packaging May Vary)

  • Based on 7,876 reviews
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$12.79 Why this price?
Black Friday Deal · 20% off was $15.99

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Availability: In Stock.
Fulfilled by Amazon

Arrives Tuesday, Dec 2
Order within 14 hours and 48 minutes
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Style: Single-Dose Pump


Size: 15g (30 Day Supply)


Features

  • TARGETS ACNE: Clear and prevent acne with the first FDA-approved prescription strength over-the-counter acne retinoid
  • CLEARS, TREATS & PREVENTS :Differin works differently than other Acne treatments by normalizing skin cell turnover and effectively targets two primary causes of Acne, clogged pores and inflammation
  • RX STRENGTH ACNE RETINOID: Adapalene was created for superior tolerability compared to other prescription retinoid products not containing Adapalene; It is suitable for use as part of your morning or evening regimen
  • DERMATOLOGIST RECOMMENDED: Water based formula, oil free, alcohol free, fragrance free, non comedogenic; Helps reduce the risk of scarring and Hyperpigmentation by treating acne
  • REAL RESULTS: In a clinical study, Differin gel provided up to 87 percent reduction in acne breakouts after 12 weeks, which will continue to improve with further use
  • THE CREATORS OF ADAPALENE: A Retinoid that Fights Acne

Description

Differin Gel Acne Treatment contains adapalene, an Rx-strength acne-fighting retinoid that helps clear breakouts where they start (works deep into pores in 5 minutes), helps prevents new acne from forming, and as a result, can restore skin�s overall tone and texture. Adapalene is the first over-the-counter active ingredient for acne in more than 30 years. It clears acne with the power of an Rx without the prescription, prevents breakouts, blackheads, whiteheads, blemishes and clogged pores, and can be used to effectively treat acne, or maskne, caused by wearing face masks or facial coverings. When used as directed, you could start to see results in as little as 1 week, and when used every single day, Differin Gel can help reduce up to 87% of acne in just 12 weeks (Cunliffe et al 1998, Galderma Laboratories).

Item Form: Gel


Scent: Unscented


Brand: Differin


Product Benefits: Anti-Acne


Skin Type: Sensitive


Product Dimensions ‏ : ‎ 1.6 x 2.65 x 6.28 inches; 1.76 ounces


Item model number ‏ : ‎ 0299.491010


Department ‏ : ‎ Beauty & Personal Care


UPC ‏ :


Manufacturer ‏ : ‎ Galderma Laboratories, Inc


Best Sellers Rank: #2,238 in Beauty & Personal Care (See Top 100 in Beauty & Personal Care) #8 in Facial Cleansing Gels


#8 in Facial Cleansing Gels:


Customer Reviews: 4.4 4.4 out of 5 stars 7,876 ratings


Frequently asked questions

If you place your order now, the estimated arrival date for this product is: Tuesday, Dec 2

Yes, absolutely! You may return this product for a full refund within 30 days of receiving it.

To initiate a return, please visit our Returns Center.

View our full returns policy here.

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Top Amazon Reviews


  • Helped my skin Alot
I’m on about day 30 and my skin is much more clear not just acne but my pores are less clogged and there’s less texture. First 2 weeks I had to only use 3x a week because my skin would get dry/irritated. Now I can use almost every day. Hoping the results get even better as time goes on.
Reviewed in the United States on September 29, 2025 by Brooke

  • Best over the counter acne treatment
Great stuff! will not stop using it as long as I keep getting acne
Reviewed in the United States on October 17, 2025 by Jay Cabo

  • Use carefully for best results
Differin really helps clear existing breakouts. For me, it's not meant to be preventative. If you overuse it (daily), it will really dry out your skin. Mine was flaking off in patches all over my face when I used it too often. Centralize it to areas only where it's needed. A little goes a long way! I can see visible improvement in size and color of breakouts overnight. ... show more
Reviewed in the United States on March 11, 2021 by Lily

  • 1MO. & 90% MASKNE FREE!
THE PURGE IS REAL! I am 41 years old, and seem to have suffered from late-onset maskne. I hadn’t been pimple prone since my younger years, and didn’t seem to have issues with breakouts until covid went endemic. But I’m on immunosuppressants and work in a hotel in NYC. So, while sticking to masking, I got stuck with maskne. Enter differin. Yeah, I’d seen the ads, but I’m not a teen. I knew about retinoids and retinols but hadn’t used them. I wasn’t fighting aging, but was fighting sudden onset cystic acne, and losing the battle of absentmindedly picking and making them worse. It’s been 30 days. Top photo was at 3 weeks, bottom is 1 month. No makeup, no filter. I regret not taking a before photo, but I didn’t even want my phone to remember what a mess things were under that mask. By the end of the 1st week I started peeling. Week 2 I had every awful kind of pimple arise. Week 3 and I was about to give up. I guess I didn’t grasp how it gets worse before it gets better. (Was hoping for ‘it stays the same and then improves.’) Ugly, awful, uncomfortable, gross. And then seemingly overnight… voila! The texture of my skin has improved overall, and my husband who’s never seen me with acne before, was legit surprised by how soft my face is. New pimples don’t seem to be leaving behind dark spots as much. This stuff seems to make your pores puke out their guts and then peels it off like it never happened. I don’t have very sensitive skin and exfoliate regularly. I am legit excited for the summer now (with sunscreen of course!) ... show more
Reviewed in the United States on May 24, 2022 by mama t. mama t.

  • Works 100%
This over the counter cream works much better for my skin issues than actual creams i used. If you think this works or not, for sure it does what it describes in the description
Reviewed in the United States on October 5, 2025 by Vasif Abilov

  • Seems good so far but...
(I have melanin skin FYI) So I've been using this product for about a week and I can already see some fading in my blemish scars so that's great. My only complaint is that if you aren't using an exfoliant before and moisturizer after it tends to make your skin flaky. Update: I stopped using the product due to it starting to slightly burn my skin. I began using Urban skin Rx and it’s getting my skin very clean. Note: that this product also will slightly make your skin flaky but not as bad as Differin. Not hating on the brand just sharing my experience bc everyone’s skin is different. I also read / heard that this Differin product used to be a prescription only so it seems like it might be better for certain extreme acne cases and not as much for scar fading. ... show more
Reviewed in the United States on August 27, 2021 by K

  • Damage box
Everything was fine. The only issue I had was the box was damaged, but besides that everything was great I only have an issue with the damage box because what if it was a gift and it came with a damage box but besides that everything was perfect thank you.
Reviewed in the United States on September 14, 2025 by monica

  • IT WORKS
I work in an 80 degree warehouse for 10 hour shifts. All the sweating, dust flying around and constantly pushing my hair from my face and neck caused me to break out pretty badly. All the acne I had cleared completely after using this three times. IT WORKS. Give it a try. I was skeptical and always am, but it really does work quickly and improved the quality of my skin. ... show more
Reviewed in the United States on August 27, 2025 by Ginny Gaddis

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