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Differin

Differin Acne Treatment Gel, 30 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 15g Pump (Packaging May Vary)

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Availability: In Stock.
Fulfilled by Amazon
Arrives Thursday, May 21
Order within 1 hour and 39 minutes
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Style: Single-Dose Pump


Size: 15g (30 Day Supply)


Features

  • TARGETS ACNE: Clear and prevent acne with the first FDA-approved prescription strength over-the-counter acne retinoid
  • CLEARS, TREATS & PREVENTS :Differin works differently than other Acne treatments by normalizing skin cell turnover and effectively targets two primary causes of Acne, clogged pores and inflammation
  • RX STRENGTH ACNE RETINOID: Adapalene was created for superior tolerability compared to other prescription retinoid products not containing Adapalene; It is suitable for use as part of your morning or evening regimen
  • DERMATOLOGIST RECOMMENDED: Water based formula, oil free, alcohol free, fragrance free, non comedogenic; Helps reduce the risk of scarring and Hyperpigmentation by treating acne
  • REAL RESULTS: In a clinical study, Differin gel provided up to 87 percent reduction in acne breakouts after 12 weeks, which will continue to improve with further use
  • THE CREATORS OF ADAPALENE: A Retinoid that Fights Acne

Description

Differin Gel Acne Treatment contains adapalene, an Rx-strength acne-fighting retinoid that helps clear breakouts where they start (works deep into pores in 5 minutes), helps prevents new acne from forming, and as a result, can restore skin�s overall tone and texture. Adapalene is the first over-the-counter active ingredient for acne in more than 30 years. It clears acne with the power of an Rx without the prescription, prevents breakouts, blackheads, whiteheads, blemishes and clogged pores, and can be used to effectively treat acne, or maskne, caused by wearing face masks or facial coverings. When used as directed, you could start to see results in as little as 1 week, and when used every single day, Differin Gel can help reduce up to 87% of acne in just 12 weeks (Cunliffe et al 1998, Galderma Laboratories).

Product Dimensions ‏ : ‎ 1.6 x 2.65 x 6.28 inches; 1.76 ounces


Item model number ‏ : ‎ 0299.491010


Department ‏ : ‎ Beauty & Personal Care


UPC ‏ : ‎


Manufacturer ‏ : ‎ Galderma Laboratories, Inc


Customer Reviews: 4.4 4.4 out of 5 stars (8,250)


Item Form: Gel


Scent Name: Unscented


Product Benefits: Anti-Acne


Skin Type: All, Sensitive


Special Ingredients: Retinoid


Target Use Body Part: Face


Active Ingredients: Adapalene 0.1%


Container Type: Tube


Brand Name: Differin


Set Name: Differin Gel Acne Treatment


UPC: 302994910106


Manufacturer Part Number: B07ZTMXJVK


Model Number: 0299.491010


Manufacturer: Galderma Laboratories, Inc


Item Type Name: Retinoid


Item Weight: 0.11 Pounds


Item Volume: 15 Fluid Ounces


Size: 15g (30 Day Supply)


Material Features: Oil Free, Alcohol Free, Fragrance Free, Non Comedogenic


Frequently asked questions

If you place your order now, the estimated arrival date for this product is: Thursday, May 21

Yes, absolutely! You may return this product for a full refund within 30 days of receiving it.

To initiate a return, please visit our Returns Center.

View our full returns policy here.

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Top Amazon Reviews

    • Highly Effective, Gentle, and Worth It for Acne-Prone Skin
Size: 15g (30 Day Supply)
This acne treatment gel is one of the best skincare products I've used. It’s powerful yet gentle, and it really delivers on clearing breakouts and preventing new ones. 🔹 Clears Acne & Helps Prevent New Breakouts It works deep into pores to target acne at the source — rather than just drying out existing pimples, it helps stop new ones from forming. After a few weeks of use, I noticed fewer breakouts and smoother skin overall. 🔹 Gentle Enough for Sensitive Skin Even though it’s a retinoid and highly effective, the formula is water-based, oil-free, and non-comedogenic. It didn’t irritate my skin or cause excessive dryness — you get the power of a prescription-strength product with a surprisingly gentle finish. 🔹 Improves Skin Texture and Reduces Acne Marks Over time, my skin tone looked more even, and old blemishes faded faster. It not only treats active acne but also helps with discoloration and overall smoothness. 🔹 Easy Daily Use & Real Results It integrates easily into a nightly skincare routine. Once applied, it absorbs quickly and layers well under moisturizer. Within a few weeks, skin felt clearer and healthier — you can actually see the difference on breakouts, tone, and texture. ✅ Pros: Powerful acne treatment that works deep in pores Helps prevent future breakouts instead of just treating existing ones Gentle enough for sensitive/acne-prone skin Improves skin texture and marks over time Easy to use daily and delivers real results ❌ Cons (minor): Skin may feel slightly dry at first — best to pair with a good moisturizer Overall: If you struggle with acne or frequent breakouts, this gel is a game-changer. Effective, gentle, and noticeable results — a solid 5-star product that I’d recommend without hesitation. ... show more
Reviewed in the United States on December 3, 2025 by Amazon Customer
    • a great new discovery for me!
Size: 15g (30 Day Supply)
This is some good stuff. I discovered it on Youtube and wanted to give it a try. I don't have acne but wanted it for aging or anti aging! It not harsh but my skin appears smooth and my pores are not as visible with the gel on. I like it better than the retina a rx it's not harsh but seems to work as well. I am even using it under my eyes with no krinkles like I get using the prescription retin a. I'm going to keep using it and save some money from the Rx. ... show more
Reviewed in the United States on May 13, 2026 by Brad H
    • Excellent
Size: 15g (30 Day Supply)
Works great and spot treatment is easy.
Reviewed in the United States on May 6, 2026 by Kindle Customer
    • Effective Acne Treatment with Careful Use
Size: 15g (30 Day Supply)
Review Image by Taylor
Differin Adapalene Gel works incredibly well for clearing acne when used correctly. I was so eager that I tried using it daily at first, and it ended up drying out my skin. Incorporating it into my routine every 3–4 days has made a huge difference, especially on my forehead and cheeks, where breakouts cleared up noticeably. It’s not as effective on the chin and around the lips, but overall it’s a fantastic treatment when used right and with moisturizer ... show more
Reviewed in the United States on April 2, 2026 by Taylor
    • Great alternative to tretinoin
Size: 15g (30 Day Supply)
This is irritating if you don’t use it with a moisturizer or apply it to the corners of your mouth. But if you spot treat and use very sparingly where you have wrinkles, it’s actually a very gentle formula and the advantage it has over retinol’s is that you can wear it during the day
Reviewed in the United States on April 10, 2026 by ANDREA
    • Not for me!
Size: 15g (30 Day Supply)
Review Image by Liv Cross
Different is not for me but I am very sensitive to topicals. Couldn’t make it through the purging. May come back to try again another day. Package was great. Easy to dispense!
Reviewed in the United States on April 23, 2026 by Liv Cross
    • Works over time
Size: 15g (30 Day Supply)
Review Image by Phil Miller
Review Image by Phil Miller
For the past year I’ve all of a sudden developed acne on my chin area that just doesn’t seem to go away. I started using Differin around 2 weeks ago ( first pic), and it really is clearing! (2nd pic is today) I did experience the “purging” that people mention, so I would agree to trust the process that it may work slow. And use a very gentle moisturizer after it dries! I have been applying it every night. ... show more
Reviewed in the United States on May 10, 2026 by Phil Miller
    • 1MO. & 90% MASKNE FREE!
Size: 15g (30 Day Supply)
Review Image by mama t.
THE PURGE IS REAL! I am 41 years old, and seem to have suffered from late-onset maskne. I hadn’t been pimple prone since my younger years, and didn’t seem to have issues with breakouts until covid went endemic. But I’m on immunosuppressants and work in a hotel in NYC. So, while sticking to masking, I got stuck with maskne. Enter differin. Yeah, I’d seen the ads, but I’m not a teen. I knew about retinoids and retinols but hadn’t used them. I wasn’t fighting aging, but was fighting sudden onset cystic acne, and losing the battle of absentmindedly picking and making them worse. It’s been 30 days. Top photo was at 3 weeks, bottom is 1 month. No makeup, no filter. I regret not taking a before photo, but I didn’t even want my phone to remember what a mess things were under that mask. By the end of the 1st week I started peeling. Week 2 I had every awful kind of pimple arise. Week 3 and I was about to give up. I guess I didn’t grasp how it gets worse before it gets better. (Was hoping for ‘it stays the same and then improves.’) Ugly, awful, uncomfortable, gross. And then seemingly overnight… voila! The texture of my skin has improved overall, and my husband who’s never seen me with acne before, was legit surprised by how soft my face is. New pimples don’t seem to be leaving behind dark spots as much. This stuff seems to make your pores puke out their guts and then peels it off like it never happened. I don’t have very sensitive skin and exfoliate regularly. I am legit excited for the summer now (with sunscreen of course!) ... show more
Reviewed in the United States on May 24, 2022 by mama t.

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