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Differin

Differin Acne Treatment Gel, 30 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 15g Pump (Packaging May Vary)

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Availability: In Stock.
Fulfilled by Amazon
Arrives Wednesday, Jul 29
Order within 4 hours and 37 minutes
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Style: Single-Dose Pump


Size: 15g (30 Day Supply)


Features

  • TARGETS ACNE: Clear and prevent acne with the first FDA-approved prescription strength over-the-counter acne retinoid
  • CLEARS, TREATS & PREVENTS :Differin works differently than other Acne treatments by normalizing skin cell turnover and effectively targets two primary causes of Acne, clogged pores and inflammation
  • RX STRENGTH ACNE RETINOID: Adapalene was created for superior tolerability compared to other prescription retinoid products not containing Adapalene; It is suitable for use as part of your morning or evening regimen
  • DERMATOLOGIST RECOMMENDED: Water based formula, oil free, alcohol free, fragrance free, non comedogenic; Helps reduce the risk of scarring and Hyperpigmentation by treating acne
  • REAL RESULTS: In a clinical study, Differin gel provided up to 87 percent reduction in acne breakouts after 12 weeks, which will continue to improve with further use
  • THE CREATORS OF ADAPALENE: A Retinoid that Fights Acne

Description

Differin Gel Acne Treatment contains adapalene, an Rx-strength acne-fighting retinoid that helps clear breakouts where they start (works deep into pores in 5 minutes), helps prevents new acne from forming, and as a result, can restore skin�s overall tone and texture. Adapalene is the first over-the-counter active ingredient for acne in more than 30 years. It clears acne with the power of an Rx without the prescription, prevents breakouts, blackheads, whiteheads, blemishes and clogged pores, and can be used to effectively treat acne, or maskne, caused by wearing face masks or facial coverings. When used as directed, you could start to see results in as little as 1 week, and when used every single day, Differin Gel can help reduce up to 87% of acne in just 12 weeks (Cunliffe et al 1998, Galderma Laboratories).

Product Dimensions ‏ : ‎ 1.6 x 2.65 x 6.28 inches; 1.76 ounces


Item model number ‏ : ‎ 0299.491010


Department ‏ : ‎ Beauty & Personal Care


UPC ‏ : ‎


Manufacturer ‏ : ‎ Galderma Laboratories, Inc


Best Sellers Rank: #1,343 in Beauty & Personal Care (See Top 100 in Beauty & Personal Care) #6 in Facial Cleansing Gels


#6 in Facial Cleansing Gels:


Customer Reviews: 4.4 4.4 out of 5 stars (8,442)


Item Form: Gel


Scent Name: Unscented


Product Benefits: Anti-Acne


Skin Type: All, Sensitive


Special Ingredients: Retinoid


Target Use Body Part: Face


Active Ingredients: Adapalene 0.1%


Container Type: Bottle


Brand Name: Differin


Set Name: Differin Gel Acne Treatment


UPC: 302994910106


Manufacturer Part Number: B07ZTMXJVK


Model Number: 0299.491010


Manufacturer: Galderma Laboratories, Inc


Item Type Name: Retinoid


Item Weight: 0.11 Pounds


Item Volume: 15 Fluid Ounces


Size: 15g (30 Day Supply)


Package Size Name: 30 Day Supply


Material Features: Alcohol Free, Fragrance Free, Non-Comedogenic, Oil Free


Frequently asked questions

If you place your order now, the estimated arrival date for this product is: Wednesday, Jul 29

Yes, absolutely! You may return this product for a full refund within 30 days of receiving it.

To initiate a return, please visit our Returns Center.

View our full returns policy here.

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Similar Products

Top Amazon Reviews

    • Highly Effective, Gentle, and Worth It for Acne-Prone Skin
Size: 15g (30 Day Supply)
This acne treatment gel is one of the best skincare products I've used. It’s powerful yet gentle, and it really delivers on clearing breakouts and preventing new ones. 🔹 Clears Acne & Helps Prevent New Breakouts It works deep into pores to target acne at the source — rather than just drying out existing pimples, it helps stop new ones from forming. After a few weeks of use, I noticed fewer breakouts and smoother skin overall. 🔹 Gentle Enough for Sensitive Skin Even though it’s a retinoid and highly effective, the formula is water-based, oil-free, and non-comedogenic. It didn’t irritate my skin or cause excessive dryness — you get the power of a prescription-strength product with a surprisingly gentle finish. 🔹 Improves Skin Texture and Reduces Acne Marks Over time, my skin tone looked more even, and old blemishes faded faster. It not only treats active acne but also helps with discoloration and overall smoothness. 🔹 Easy Daily Use & Real Results It integrates easily into a nightly skincare routine. Once applied, it absorbs quickly and layers well under moisturizer. Within a few weeks, skin felt clearer and healthier — you can actually see the difference on breakouts, tone, and texture. ✅ Pros: Powerful acne treatment that works deep in pores Helps prevent future breakouts instead of just treating existing ones Gentle enough for sensitive/acne-prone skin Improves skin texture and marks over time Easy to use daily and delivers real results ❌ Cons (minor): Skin may feel slightly dry at first — best to pair with a good moisturizer Overall: If you struggle with acne or frequent breakouts, this gel is a game-changer. Effective, gentle, and noticeable results — a solid 5-star product that I’d recommend without hesitation. ... show more
Reviewed in the United States on December 3, 2025 by Amazon Customer
    • It works but be careful!! It works but be careful!!
Size: 15g (30 Day Supply)
Review Image by Amanda Martinez
This stuff is really good it does clear up acne but make sure you start SLOW!! Read instructions carefully and only use once a week at first. I thought my skin could take more than it could (twice a week) and my eyes got so red and irritated. Don’t apply around eyes at all and make sure you moisturize a lot because it will dry you out - but it really works!!! ... show more
Reviewed in the United States on May 26, 2026 Reviewed in the United States on May 26, 2026 by Amanda Martinez
    • a great new discovery for me!
Size: 15g (30 Day Supply)
This is some good stuff. I discovered it on Youtube and wanted to give it a try. I don't have acne but wanted it for aging or anti aging! It not harsh but my skin appears smooth and my pores are not as visible with the gel on. I like it better than the retina a rx it's not harsh but seems to work as well. I am even using it under my eyes with no krinkles like I get using the prescription retin a. I'm going to keep using it and save some money from the Rx. ... show more
Reviewed in the United States on May 13, 2026 by Brad H
    • Slow but works
Size: 15g (30 Day Supply)
Works well, it’s slow, trust the process, be consistent, it is also very heavy for sensitive skin so use only once a week or two.
Reviewed in the United States on April 28, 2026 by Anthony San Roman
    • Recommended
Size: 15g (30 Day Supply)
I can see a difference in my skin. Helps with blemishes.
Reviewed in the United States on June 10, 2026 by Amazon Customer
    • Not for me! Not for me!
Size: 15g (30 Day Supply)
Review Image by Liv Cross
Different is not for me but I am very sensitive to topicals. Couldn’t make it through the purging. May come back to try again another day. Package was great. Easy to dispense!
Reviewed in the United States on April 23, 2026 Reviewed in the United States on April 23, 2026 by Liv Cross
    • Great alternative to tretinoin
Size: 15g (30 Day Supply)
This is irritating if you don’t use it with a moisturizer or apply it to the corners of your mouth. But if you spot treat and use very sparingly where you have wrinkles, it’s actually a very gentle formula and the advantage it has over retinol’s is that you can wear it during the day
Reviewed in the United States on April 10, 2026 by ANDREA
    • Not just for acne
Size: 15g (30 Day Supply)
Recommended by my esthetician, goes on at night as a retinoid product. Easy to use and my skin looks great.
Reviewed in the United States on June 21, 2026 by JJ

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