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Nike Mens Run Defy Road Running Shoes

  • Based on 639 reviews
Condition: New
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$45.50 Why this price?
Holiday Deal · 30% off was $65.00

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As low as $11 / mo
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This item's return window has been extended for the holiday season: FREE refund/replacement until Jan 31, 2026

To qualify for a full refund, items must be returned in their original, unused condition. If an item is returned in a used, damaged, or materially different state, you may be granted a partial refund.

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Availability: Only 4 left in stock, order soon!
Fulfilled by Amazon

Arrives Jan 11 – Jan 24
Order within 23 hours and 33 minutes
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Size: 12


Color: Black/White


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Frequently asked questions

If you place your order now, the estimated arrival date for this product is: Jan 11 – Jan 24

Yes, absolutely! You may return this product for a full refund within 30 days of receiving it.

To initiate a return, please visit our Returns Center.

View our full returns policy here.

  • Klarna Financing
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  • Affirm Financing
  • Afterpay Financing
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  • Financing through Apple Pay
Leasing options through Acima may also be available during checkout.

Learn more about financing & leasing here.

Top Amazon Reviews


  • Most comfortable fit
I have been looking for some sneakers for some time and now I am no longer looking. These sneakers feel more comfortable than I expected and look sharp. They are well made and I use them workouts and just walking about. Very happy I got them.
Reviewed in the United States on November 11, 2025 by Jerry

  • Good running shoes
Really like it was true to size. Looks good and feels comfortable on my feet.
Reviewed in the United States on October 21, 2025 by Buyer

  • Reliable, breathable, and comfortable!
If you’re after a reliable, comfortable running shoe for daily wear, errands, casual runs or walking, the Run Defy is a very solid choice: breathable, cushioned, stylish and good value. If your focus is high mileage, performance runs or rugged conditions, you may want to step up to a more premium model. ... show more
Reviewed in the United States on October 23, 2025 by Aditya Soni

  • Worth the purchase
These shoes are light and comfortable. Fits true to size.
Reviewed in the United States on November 18, 2025 by Jen

  • Good shoes.
Very comfortable. Feel nice and supportive while the shoe is soft and flexible.
Reviewed in the United States on November 23, 2025 by Christina D

  • Cushy
Let me preface this review with I didn’t buy these shoes for running. I’ve had a pair of Nikes for 15 years and straight up, they’re still comfy and in great shape. So, I bought these. They feel good on my feet, nice and cushy. They are requiring a break in as they’re tight across my toes. They look great! I’m happy and will probably always buy Nike shoes. ... show more
Reviewed in the United States on October 7, 2025 by Margie H.

  • Great Shoes - Great Fit
I run 6 days a week, every week and these shoes are great! They have good support and are very secure on your feet. And at a great price.
Reviewed in the United States on November 13, 2025 by Jesse Edgein

  • Great running shoe!
Size: 10.5 Color: Black/Cool Grey/University Red/White
These are very comfortable shoes and also look great. I may buy them in other colors for casual wear times.
Reviewed in the United States on November 4, 2025 by Kindle Customer

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